Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Giorgia Pallocca"'
Autor:
Tamara Tal, Oddvar Myhre, Ellen Fritsche, Joëlle Rüegg, Kai Craenen, Kiara Aiello-Holden, Caroline Agrillo, Patrick J. Babin, Beate I. Escher, Hubert Dirven, Kati Hellsten, Kristine Dolva, Ellen Hessel, Harm J. Heusinkveld, Yavor Hadzhiev, Selma Hurem, Karolina Jagiello, Beata Judzinska, Nils Klüver, Anja Knoll-Gellida, Britta A. Kühne, Marcel Leist, Malene Lislien, Jan L. Lyche, Ferenc Müller, John K. Colbourne, Winfried Neuhaus, Giorgia Pallocca, Bettina Seeger, Ilka Scharkin, Stefan Scholz, Ola Spjuth, Monica Torres-Ruiz, Kristina Bartmann
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While the public
Externí odkaz:
https://doaj.org/article/84a7889b64d34295a7a44cec97e647b1
Autor:
Giorgia Pallocca, Marco Fabbri, Silvia Nerini-Molteni, Francesca Pistollato, Dimitra Zagoura, Maria Grazia Sacco, Laura Gribaldo, Susanne Bremer-Hoffmann, Anna Bal-Price
Publikováno v:
Toxics, Vol 2, Iss 3, Pp 443-463 (2014)
MicroRNAs (miRNAs) are implicated in the epigenetic regulation of several brain developmental processes, such as neurogenesis, neuronal differentiation, neurite outgrowth, and synaptic plasticity. The main aim of this study was to evaluate whether mi
Externí odkaz:
https://doaj.org/article/32988d559e3441c39f392dc4ece06159
Autor:
Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jírová, Kristina Kejlová, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thöne-Reineke, Thomas Hartung, Giorgia Pallocca, Costanza Rovida, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Krämer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Eliška Kuchovská, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kränzlin, Bettina Seeger, Maren von Köckritz-Blickwede, José M. Sánchez-Morgado, Viola Galligioni, Daniel Ruiz-Pérez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stępnik, Zuzanna Sobańska, Edyta Reszka, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Emma Svensk, Christopher R. Cederroth, Jenny Sandström, Ian Ragan, Nataliia Bubalo, Jens Kurreck, Horst Spielmann
Publikováno v:
Alternatives to Laboratory Animals. 50:381-413
The adoption of Directive 2010/63/EU on the protection of animals used for scientific purposes has given a major push to the formation of Three Rs initiatives in the form of centres and platforms. These centres and platforms are dedicated to the so-c
Autor:
Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jírová, Kristina Kejlová, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thöne-Reineke, Thomas Hartung, Giorgia Pallocca, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Krämer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kränzlin, Bettina Seeger, Maren von Köckritz-Blickwede, José M. Sánchez-Morgado, Viola Galligioni, Daniel Ruiz-Pérez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stępnik, Zuzanna Sobańska, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Christopher R. Cederroth, Jenny Sandström, Ian Ragan, Nataliia Bubalo, Horst Spielmann
Publikováno v:
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Public awareness and discussion about animal experiments and replacement methods has greatly increased in recent years. The term ‘the Three Rs’, which stands for the Replacement, Reduction and Refinement of animal experiments, is inseparably link
Publikováno v:
Archives of Toxicology
The COVID-19-inducing virus, SARS-CoV2, is likely to remain a threat to human health unless efficient drugs or vaccines become available. Given the extent of the current pandemic (people in over one hundred countries infected) and its disastrous effe
Autor:
Giorgia, Pallocca, Marcel, Leist
Publikováno v:
ALTEX-Alternatives to Animal Experimentation
In many countries, animal experiments can only be performed when their necessity has been demonstrated in a legal document. As the usefulness of animals in research is also a significant societal and political issue, criteria to structure debates and
Autor:
Anja Wilmes, Tobias Strassfeld, Harry Vrieling, Manoj Kumar, Balázs Mihalik, Costanza Rovida, Giorgia Pallocca, Nanette G Vrijenhoek, Ciarán Fisher, Bart van der Burg, Thomas Braunbeck, Xenia Dolde, Alice Krebs, Zofia Janstova, Béla Z. Schmidt, Wiebke Albrecht, Jan G. Hengstler, Tim Brecklinghaus, David A. Fluri, J. J. W. A. Boei, Thomas Exner, Marcel Leist, Tanja Waldmann, Jaffar Kisitu, Anna-Katharina Holzer, Manuel Pastor, Joh Dokler, Andrea Paola Cediel Ulloa, Paul Jennings, Barbara M.A. van Vugt-Lussenburg, Bas ter Braak, Bob van de Water, Anna Forsby, Maja Brajnik, Wolfgang Moritz, Catherine M. Verfaillie, Johannes P Schimming, Rebecca von Hellfeld, Alice Limonciel, Francois Busquet, Julianna Kobolák, Ugis Sarkans, Regina Stöber, Jessica Lundqvist, Andras Dinnyes
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461
Hazard assessment, based on new approach methods (NAM), requires the use of batteries of assays, where individual tests may be contributed by different laboratories. A unified strategy for such collaborative testing is presented. It details all proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e81d40cbe9c93d9b654557d3afcabe
https://hdl.handle.net/1887/3184413
https://hdl.handle.net/1887/3184413
Autor:
Wolf A, Uwe Marx, Donna L. Mendrick, Mario Beilmann, Murat Cirit, Julia Hoeng, Giorgia Pallocca, Linda G. Griffith, Geraldine A. Hamilton, Isabell Durieux, Elizabeth Baker, Alexander G. Tonevitsky, Helena T. Hogberg, Peter Loskill, Anita R. Iskandar, Thomas Hartung, Akabane T, Neumann T, David J. Hughes, Florian Fuchs, Kuehnl J, Adrian Roth, Kojima H, Thomas Steger-Hartmann, Beken S, Rhiannon David, Suzanne Fitzpatrick, Danilo A. Tagle, Olivier Frey, Lena Smirnova, Marcel Leist, Van den Eijnden-van Raaij J, Dehne Em, Li B, Trapecar M, Brendler-Schwaab S, Donald E. Ingber, Zhou X, Ivan Rusyn, Toshiyuki Kanamori, Watanabe K, Tommy B. Andersson, Tsyb S, Paul Vulto, Lorna Ewart, van de Water B
Publikováno v:
ALTEX
The first microfluidic microphysiological systems (MPS) entered the academic scene more than 15 years ago and were considered an enabling technology to human (patho)biology in vitro and, therefore, provide alternative approaches to laboratory animals
Autor:
Julia Hoeng, Joëlle Rüegg, Costanza Rovida, Matthias Herzler, Sofia B. Leite, Barry Hardy, Thomas Steger-Hartmann, Sandra Coecke, Francois Busquet, Thomas Exner, Barbara M.A. van Vugt-Lussenburg, Mirjam Luijten, Janine Ezendam, Jan G. Hengstler, Florian Gantner, Tanja Waldmann, Susanne Hougaard Bennekou, Kristina Fant, Bart van der Burg, Alice Krebs, Marcel Leist, Daniel R. Dietrich, Albert Braeuning, Ellen Fritsche, Emma Pedersen, Giorgia Pallocca, Tuula Heinonen, Mario Beilmann, Andrea Terron, Philip Hewitt, Thomas Hartung, Olesja Bondarenko, Stefan Kustermann, Hennicke Kamp, Torsten R. Dunkern, Martin F. Wilks
Publikováno v:
Krebs, A, Waldmann, T, Wilks, M F, Van Vugt-Lussenburg, B M A, Van der Burg, B, Terron, A, Steger-Hartmann, T, Ruegg, J, Rovida, C, Pedersen, E, Pallocca, G, Luijten, M, Leite, S B, Kustermann, S, Kamp, H, Hoeng, J, Hewitt, P, Herzler, M, Hengstler, J G, Heinonen, T, Hartung, T, Hardy, B, Gantner, F, Fritsche, E, Fant, K, Ezendam, J, Exner, T, Dunkern, T, Dietrich, D R, Coecke, S, Busquet, F, Braeuning, A, Bondarenko, O, Hougaard Bennekou, S, Beilmann, M & Leist, M 2020, ' Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data ', A L T E X. Alternatives to Animal Experimentation, vol. 37, no. 1, pp. 164-164 . https://doi.org/10.14573/altex.1909271e
Only few cell-based test methods are described by Organisation for Economic Co-operation and Development (OECD) test guidelines or other regulatory references (e.g., the European Pharmacopoeia). The majority of toxicity tests still falls into the cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17547a120d82232053cfcea5a885530
https://orbit.dtu.dk/en/publications/07a9a3c2-fd15-408a-a12a-cade067fb4c2
https://orbit.dtu.dk/en/publications/07a9a3c2-fd15-408a-a12a-cade067fb4c2
Autor:
Grace Patlewicz, Matthias Herzler, Manuela Pavan, Marcel Leist, Thomas Hartung, Tara S. Barton-Maclaren, Susanne Hougaard Bennekou, Kerry Nugent, Simona Kovarich, Alexandra Maertens, P. Charukeshi Chandrasekera, Bruno Hubesch, Joop de Knecht, Nicole Kleinstreuer, Francesca Caloni, Lena Smirnova, Sylvia Escher, Mark T. D. Cronin, Emilio Benfenati, Giorgia Pallocca, Jaffar Kisitu, Manuel Pastor, Christophe Chesne, Hennicke Kamp, Michael Schwarz, Suzanne Fitzpatrick, Octavio Augusto França Presgrave, Daniel R. Dietrich, Takashi Yamada, Costanza Rovida, Brenna M. Flannery
Publikováno v:
ALTEX
Rovida, C, Barton-Maclaren, T, Benfenati, E, Caloni, F, Chandrasekera, C, Chesne, C, Cronin, M T D, De Knecht, J, Dietrich, D R, Escher, S E, Fitzpatrick, S, Flannery, B, Herzler, M, Hougaard Bennekou, S, Hubesch, B, Kamp, H, Kisitu, J, Kleinstreuer, N, Kovarich, S, Leist, M, Maertens, A, Nugent, K, Pallocca, G, Pastor, M, Patlewicz, G, Pavan, M, Presgrave, O, Smirnova, L, Schwarz, M, Yamada, T & Hartung, T 2020, ' Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology ', A L T E X. Alternatives to Animal Experimentation, vol. 37, no. 4, pp. 579-606 . https://doi.org/10.14573/altex.1912181
Rovida, C, Barton-Maclaren, T, Benfenati, E, Caloni, F, Chandrasekera, C, Chesne, C, Cronin, M T D, De Knecht, J, Dietrich, D R, Escher, S E, Fitzpatrick, S, Flannery, B, Herzler, M, Hougaard Bennekou, S, Hubesch, B, Kamp, H, Kisitu, J, Kleinstreuer, N, Kovarich, S, Leist, M, Maertens, A, Nugent, K, Pallocca, G, Pastor, M, Patlewicz, G, Pavan, M, Presgrave, O, Smirnova, L, Schwarz, M, Yamada, T & Hartung, T 2020, ' Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology ', A L T E X. Alternatives to Animal Experimentation, vol. 37, no. 4, pp. 579-606 . https://doi.org/10.14573/altex.1912181
Read-across (RAx) translates available information from well-characterized chemicals tothe substance for which there is a toxicological data gap. The OECD is working on case studies to probe general applicability of RAx, and several regulations (e.g.