The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells

Autor: Giorgia Maroni, Daniele Panetta, Raffaele Luongo, Indira Krishnan, Federica La Rosa, Daniela Campani, Piero Salvadori, Patricia Iozzo, Francesco Blasi, Dmitry Penkov, Elena Levantini, Maria Cristina Magli

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 15, p 3639 (2019)

Molecular mechanisms governing cell fate decision events in bone marrow mesenchymal stromal cells (MSC) are still poorly understood. Herein, we investigated the homeobox gene Prep1 as a candidate regulatory molecule, by adopting Prep1 hypomorphic mic

Externí odkaz: https://doaj.org/article/4f0a79e29118495dafb1146770bf3835

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Autor: Olivier Kocher, Maria Cristina Magli, Marzia Del Re, Sam Fox, Assunta De Rienzo, Barbara Storti, Virginia Savova, Mahmoud A. Bassal, Rapolas Zilionis, Kimberly Vermilya, Stefania Crucitta, Art Branstrom, Elena Levantini, Eva Csizmadia, Claire V. Meyerovitz, Riccardo Panella, Rachel D. Levy, Valerie A. Maymi, Chee Wai Fhu, Daniela S. Basseres, Henry Yang, Alessandra Giorgetti, Marla Weetall, Raphael Bueno, Raffaele Ciampi, Giorgia Maroni, Julio Castaño, Corinne E. Gustafson, John G. Clohessy, Ranieri Bizzarri, Nicole Pandell, Azhar Ali, Allon M. Klein, Indira Krishnan, Jia Li, Junyan Zhang, Daniel G. Tenen, Romano Danesi, Robert S. Welner, Peter J. Tramontozzi

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Communications biology, Berlin : Nature research, 2021, vol. 4, iss. 1, art. no. 370, p. [1-15]
Communications Biology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications biology 4 (2021): 370-1–370-15. doi:10.1038/s42003-021-01897-6
info:cnr-pdr/source/autori:Maroni G.; Bassal M.A.; Krishnan I.; Fhu C.W.; Savova V.; Zilionis R.; Maymi V.A.; Pandell N.; Csizmadia E.; Zhang J.; Storti B.; Castano J.; Panella R.; Li J.; Gustafson C.E.; Fox S.; Levy R.D.; Meyerovitz C.V.; Tramontozzi P.J.; Vermilya K.; De Rienzo A.; Crucitta S.; Basseres D.S.; Weetall M.; Branstrom A.; Giorgetti A.; Ciampi R.; Del Re M.; Danesi R.; Bizzarri R.; Yang H.; Kocher O.; Klein A.M.; Welner R.S.; Bueno R.; Magli M.C.; Clohessy J.G.; Ali A.; Tenen D.G.; Levantini E./titolo:Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer/doi:10.1038%2Fs42003-021-01897-6/rivista:Communications biology/anno:2021/pagina_da:370-1/pagina_a:370-15/intervallo_pagine:370-1–370-15/volume:4

Lung cancer is the leading cause of cancer deaths. Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted via single cell RNA sequencing in aggressive human adenocarcinomas (carrying Kras-mutations) and comparab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb8c66e11c1d739999424c93142dd2a
http://hdl.handle.net/2445/177192

Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species

Autor: Daniel G. Tenen, William G. Richards, Sun Choi, Elena Levantini, Assunta De Rienzo, Clara M. Kerwin, Virginia Savova, Claire V. Meyerovitz, David Zemmour, Hatice D. Saatcioglu, Raphael Bueno, Rapolas Zilionis, Giorgia Maroni, Allon M. Klein, Christina Pfirschke, Camilla Engblom, Indira Krishnan, Mikael J. Pittet

Publikováno v: Immunity, Vol. 50, No 5 (2019) pp. 1317-1334.e10
Immunity
Immunity (Camb. Mass.) 50 (2019): 1317–+. doi:10.1016/j.immuni.2019.03.009
info:cnr-pdr/source/autori:Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM/titolo:Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species/doi:10.1016%2Fj.immuni.2019.03.009/rivista:Immunity (Camb. Mass.)/anno:2019/pagina_da:1317/pagina_a:+/intervallo_pagine:1317–+/volume:50

Summary Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells, and neutrophils, and have emerged as key regulators of cancer growth. These cells can diversify into a spectrum of states, which might promote or limit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c006a38e5bd51f04d9d84a42965db55
https://archive-ouverte.unige.ch/unige:154045

Prep1 prevents premature adipogenesis of mesenchymal progenitors

Autor: Raffaele Luongo, Dmitry Penkov, Marco J. Morelli, Maria Cristina Magli, Elena Levantini, Giorgia Maroni, Francesco Blasi, Alexander V. Egorov, Vsevolod A. Tkachuk

Publikováno v: Scientific Reports
Scientific reports (Nature Publishing Group) 7 (2017). doi:10.1038/s41598-017-15828-1
info:cnr-pdr/source/autori:Maroni, Giorgia; Tkachuk, Vsevolod A.; Egorov, Alexander; Morelli, Marco J.; Luongo, Raffaele; Levantini, Elena; Blasi, Francesco; Magli, Maria Cristina; Penkov, Dmitry/titolo:Prep1 prevents premature adipogenesis of mesenchymal progenitors/doi:10.1038%2Fs41598-017-15828-1/rivista:Scientific reports (Nature Publishing Group)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Transcriptional regulators are crucial in adipocyte differentiation. We now show that the homeodomain-containing transcription factor Prep1 is a repressor of adipogenic differentiation since its down-regulation (DR) in both ex vivo bone marrow-derive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80babce86c0fba34892602f183a44d7d
http://europepmc.org/articles/PMC5686065

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression

Autor: Pu Zhang, Atsushi Iwama, Meritxell Alberich-Jorda, Maria Cristina Magli, Junyan Zhang, Daniel G. Tenen, Christopher J. Hetherington, Henry Yang, Min Ye, Daniela S. Basseres, Thomas W. Davis, Kol Jia Yong, Elena Levantini, Lorena Lobo de Figueiredo-Pontes, Bing Lim, Alain C. Borczuk, Hong Zhang, Giorgia Maroni, Ross A. Soo, Wen Cai Zhang, Benedict Yan, Balazs Halmos, Liangxian Cao, Donna Neuberg, Nadiya Sydorenko, Robert S. Welner, Olivier Kocher, Young Choon Moon, Chiara Battelli, Karen B. O'Brien, Lyuba Varticovski, Bhavin Thakkar

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Science translational medicine 8 (2016): 350ra104. doi:10.1126/scitranslmed.aad6066
info:cnr-pdr/source/autori:Yong K.J.; Basseres D.S.; Welner R.S.; Zhang W.C.; Yang H.; Yan B.; Alberich-Jorda M.; Zhang J.; De Figueiredo-Pontes L.L.; Battelli C.; Hetherington C.J.; Ye M.; Zhang H.; Maroni G.; O'Brien K.; Magli M.C.; Borczuk A.C.; Varticovski L.; Kocher O.; Zhang P.; Moon Y.-C.; Sydorenko N.; Cao L.; Davis T.W.; Thakkar B.M.; Soo R.A.; Iwama A.; Lim B.; Halmos B.; Neuberg D.; Tenen D.G.; Levantini E./titolo:Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPa expression/doi:10.1126%2Fscitranslmed.aad6066/rivista:Science translational medicine/anno:2016/pagina_da:350ra104/pagina_a:/intervallo_pagine:350ra104/volume:8
Sci Transl Med

Lung cancer is the most common cause of cancer deaths. The expression of the transcription factor C/EBPα (CCAAT/enhancer binding protein α) is frequently lost in non-small cell lung cancer, but the mechanisms by which C/EBPα suppresses tumor forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60ee0d58b50b838990060c366b354ae
https://doi.org/10.1126/scitranslmed.aad6066