Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Giorgia Centonze"'
Autor:
Giorgia Centonze, Dora Natalini, Silvia Grasso, Alessandro Morellato, Vincenzo Salemme, Alessio Piccolantonio, Giacomo D’Attanasio, Aurora Savino, Olga Teresa Bianciotto, Matteo Fragomeni, Andrea Scavuzzo, Matteo Poncina, Francesca Nigrelli, Mario De Gregorio, Valeria Poli, Pietro Arina, Daniela Taverna, Joanna Kopecka, Sirio Dupont, Emilia Turco, Chiara Riganti, Paola Defilippi
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-16 (2023)
Abstract p140Cap is an adaptor protein involved in assembling multi-protein complexes regulating several cellular processes. p140Cap acts as a tumor suppressor in breast cancer (BC) and neuroblastoma patients, where its expression correlates with a b
Externí odkaz:
https://doaj.org/article/9b85e2507048469f836b2d800e0a4611
Autor:
Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella, Federico Moietta, Alessio Piccolantonio, Enrico Moiso, Giorgia Centonze, Marta Manco, Andrea Guala, Alessia Lamolinara, Costanza Angelini, Alessandro Morellato, Dora Natalini, Raffaele Calogero, Danny Incarnato, Salvatore Oliviero, Laura Conti, Manuela Iezzi, Daniela Tosoni, Giovanni Bertalot, Stefano Freddi, Francesco A. Tucci, Francesco De Sanctis, Cristina Frusteri, Stefano Ugel, Vincenzo Bronte, Federica Cavallo, Paolo Provero, Marta Gai, Daniela Taverna, Emilia Turco, Salvatore Pece, Paola Defilippi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition
Externí odkaz:
https://doaj.org/article/6ef08fc8d1c74047923f8519dfa3b883
Autor:
Vincenzo Salemme, Giorgia Centonze, Lidia Avalle, Dora Natalini, Alessio Piccolantonio, Pietro Arina, Alessandro Morellato, Ugo Ala, Daniela Taverna, Emilia Turco, Paola Defilippi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Breast cancer is a highly heterogeneous disease, at both inter- and intra-tumor levels, and this heterogeneity is a crucial determinant of malignant progression and response to treatments. In addition to genetic diversity and plasticity of cancer cel
Externí odkaz:
https://doaj.org/article/cb9e2bab7a854b828696358e90291ed1
Autor:
Giorgia Centonze, Dora Natalini, Alessio Piccolantonio, Vincenzo Salemme, Alessandro Morellato, Pietro Arina, Chiara Riganti, Paola Defilippi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Cholesterol is an essential lipid primarily synthesized in the liver through the mevalonate pathway. Besides being a precursor of steroid hormones, bile acid, and vitamin D, it is an essential structural component of cell membranes, is enriched in me
Externí odkaz:
https://doaj.org/article/9304587596c14df995904e317b938839
Autor:
Giorgia Centonze, Dora Natalini, Vincenzo Salemme, Andrea Costamagna, Sara Cabodi, Paola Defilippi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
p130Cas/BCAR1 is an adaptor protein devoid of any enzymatic or transcriptional activity, whose modular structure with various binding motifs, allows the formation of multi-protein signaling complexes. This results in the induction and/or maintenance
Externí odkaz:
https://doaj.org/article/34a5ddd488fd48d6b8daf5fef9a8b442
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Breast cancer progression is a complex process controlled by genetic and epigenetic factors that coordinate the crosstalk between tumor cells and the components of tumor microenvironment (TME). Among those, the immune cells play a dual role during ca
Externí odkaz:
https://doaj.org/article/c4d887e6eed1490b836e7ca614812bc2
Publikováno v:
Cells, Vol 11, Iss 7, p 1130 (2022)
Keratinocyte stem cells play a fundamental role in homeostasis and repair of stratified epithelial tissues. Transplantation of cultured keratinocytes autografts provides a landmark example of successful cellular therapies by restoring durable integri
Externí odkaz:
https://doaj.org/article/1538baa0af3d4ae480dca9e3d7b77493
Autor:
Silvia Grasso, Jennifer Chapelle, Vincenzo Salemme, Simona Aramu, Isabella Russo, Nicoletta Vitale, Ludovica Verdun di Cantogno, Katiuscia Dallaglio, Isabella Castellano, Augusto Amici, Giorgia Centonze, Nanaocha Sharma, Serena Lunardi, Sara Cabodi, Federica Cavallo, Alessia Lamolinara, Lorenzo Stramucci, Enrico Moiso, Paolo Provero, Adriana Albini, Anna Sapino, Johan Staaf, Pier Paolo Di Fiore, Giovanni Bertalot, Salvatore Pece, Daniela Tosoni, Stefano Confalonieri, Manuela Iezzi, Paola Di Stefano, Emilia Turco, Paola Defilippi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
p140Cap adaptor proteins interfere with adhesion and growth factor-dependent signalling in cancer cells but the mechanisms are unclear. Here the authors show that p140Cap interferes with ERBB2-dependent activation of Rac GTPase-controlled circuitries
Externí odkaz:
https://doaj.org/article/3f467620764d4f4e9419cd933a8e92a7
Autor:
Lorena Quirico, Francesca Orso, Stefania Cucinelli, Mladen Paradzik, Dora Natalini, Giorgia Centonze, Alberto Dalmasso, Sofia La Vecchia, Martina Coco, Valentina Audrito, Chiara Riganti, Paola Defilippi, Daniela Taverna
Publikováno v:
Cellular and molecular life sciences
MicroRNAs (miRNAs) are small, non-coding RNAs about 22 nucleotides in length that regulate the expression of target genes post-transcriptionally, and are highly involved in cancer progression. They are able to impact a variety of cell processes such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f372ea02ddb30c1c908857f8a6bdb2
https://doi.org/10.1007/s00018-022-04228-y
https://doi.org/10.1007/s00018-022-04228-y
Autor:
Dora Natalini, Ugo Ala, Giorgia Centonze, Vincenzo Salemme, Daniela Taverna, Paola Defilippi, Alessandro Morellato, Costanza Angelini, Emilia Turco, Jennifer Chapelle
Publikováno v:
Cellular and Molecular Life Sciences
The p140Cap adaptor protein is a scaffold molecule encoded by the SRCIN1 gene, which is physiologically expressed in several epithelial tissues and in the neurons. However, p140Cap is also strongly expressed in a significant subset of cancers includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5d14afac69f59db4468e1f0191628f
http://europepmc.org/articles/PMC7904710
http://europepmc.org/articles/PMC7904710