Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Giorgia, Rota"'
Autor:
George Coukos, Evripidis Lanitis, Melita Irving, Paris Kosti, Catherine Ronet, Elisabetta Cribioli, Giorgia Rota, Aodrenn Spill, Patrick Reichenbach, Vincent Zoete, Denarda Dangaj Laniti
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Background The adoptive transfer of chimeric antigen receptor (CAR)-T cells has emerged as a potent immunotherapy against some hematological malignancies but not yet for epithelial-derived solid tumors. One critical issue is the paucity of broadly ex
Externí odkaz:
https://doaj.org/article/00de700490344b409b7db715eb77e9ab
Autor:
Charlène Niogret, S. M. Shahjahan Miah, Giorgia Rota, Nicolas P. Fonta, Haiping Wang, Werner Held, Walter Birchmeier, Veronica Sexl, Wentian Yang, Eric Vivier, Ping-Chih Ho, Laurent Brossay, Greta Guarda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The phosphatase Shp-2 was implicated in NK cell education due to its reported association with inhibitory receptors, but its function in this context is unclear. Here the authors show that Shp-2 is not required for NK cell function, but is necessary
Externí odkaz:
https://doaj.org/article/41cf5051ab934c2b9282cb0fc85ec566
Autor:
Giorgia Rota, Charlène Niogret, Anh Thu Dang, Cristina Ramon Barros, Nicolas Pierre Fonta, Francesca Alfei, Leonor Morgado, Dietmar Zehn, Walter Birchmeier, Eric Vivier, Greta Guarda
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 39-49 (2018)
Summary: In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether
Externí odkaz:
https://doaj.org/article/b395a1ba02e4467bb0fd84774174e3f0
Autor:
Laurent Schmied, Thuy T. Luu, Jonas N. Søndergaard, Sophia H. Hald, Stephan Meinke, Dara K. Mohammad, Sunitha B. Singh, Corinna Mayer, Giovanna Perinetti Casoni, Michael Chrobok, Heinrich Schlums, Giorgia Rota, Hieu M. Truong, Lisa S. Westerberg, Greta Guarda, Evren Alici, Arnika K. Wagner, Nadir Kadri, Yenan T. Bryceson, Mezida B. Saeed, Petter Höglund
Publikováno v:
Science Signaling. 16
Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends on balanced signaling from activating receptors, recognizing products from tumors or viruses, and inhibitory receptors (such as KIR/Ly49), which recognize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe137ff5224b9f1d97b3e6d81204c2fe
https://doi.org/10.1126/scisignal.abq0752
https://doi.org/10.1126/scisignal.abq0752
Autor:
Kristina Ludigs, Camilla Jandus, Daniel T. Utzschneider, Francesco Staehli, Stéphanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero, Greta Guarda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high M
Externí odkaz:
https://doaj.org/article/5daa48a82f9b456488d8d66573ddc116
Autor:
Pedro M O Ventura, Milica Gakovic, Berenice A Fischer, Laura Spinelli, Giorgia Rota, Shalini Pathak, Hanif J Khameneh, Alessandro Zenobi, Sarah Thomson, Walter Birchmeier, Doreen A Cantrell, Greta Guarda
Publikováno v:
EMBO reports. 23(11)
Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as PD-1. Blockade of PD-1 leads to T cell reinvigoration and is increasingly applied as an effective anticancer trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f769872fe15f010880618bf0b2310e85
https://pubmed.ncbi.nlm.nih.gov/36194675
https://pubmed.ncbi.nlm.nih.gov/36194675
Autor:
Laurent Schmied, Thuy T. Luu, Jonas N. Søndergaard, Stephan Meinke, Dara K. Mohammad, Sunitha B. Singh, Corinna Mayer, Giovanna P. Casoni, Michael Chrobok, Heinrich Schlums, Giorgia Rota, Hieu M. Truong, Lisa S. Westerberg, Greta Guarda, Evren Alici, Arnika K. Wagner, Nadir Kadri, Yenan T. Bryceson, Mezida B. Saeed, Petter Höglund
Signaling via inhibitory KIR/Ly49 receptors preserves natural killer (NK) cell self-tolerance but also conveys NK cell reactivity towards MHC class-I low target cells in an education process. Here, we demonstrate that mouse NK cell education by H-2Dd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bee51cff1904bfe834a5903c3c74a94
https://doi.org/10.1101/2022.03.08.483415
https://doi.org/10.1101/2022.03.08.483415
Autor:
Kristina Ludigs, Queralt Seguín-Estévez, Sylvain Lemeille, Isabel Ferrero, Giorgia Rota, Sonia Chelbi, Chantal Mattmann, H Robson MacDonald, Walter Reith, Greta Guarda
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005088 (2015)
MHC class II (MHCII) genes are transactivated by the NOD-like receptor (NLR) family member CIITA, which is recruited to SXY enhancers of MHCII promoters via a DNA-binding "enhanceosome" complex. NLRC5, another NLR protein, was recently found to contr
Externí odkaz:
https://doaj.org/article/43e60c513221439798aebe7744bcb1a6
Autor:
Pedro Ventura, Milica Gakovic, Berenice Fischer, Sarah Thomson, Hanif J Khameneh, Alessandro Zenobi, Giorgia Rota, Eric Vivier, Walter Birchmeier, Doreen Cantrell, Greta Guarda
Publikováno v:
Cancer Immunology Research. 10:P051-P051
After exposure to chronic inflammatory stimuli, the immune system can switch from a functional state where it acts to reestablish homeostasis to a dysfunctional state. In the context of cancer, T cells that become exposed to continuous stimulation ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790dce834f85b2231c3873880e0f3f4c
https://doi.org/10.1158/2326-6074.tumimm21-p051
https://doi.org/10.1158/2326-6074.tumimm21-p051
Autor:
Aodrenn Spill, Giorgia Rota, George Coukos, Vincent Zoete, Denarda Dangaj Laniti, Catherine Ronet, Melita Irving, Paris Kosti, Patrick Reichenbach, Evripidis Lanitis, Elisabetta Cribioli
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundThe adoptive transfer of chimeric antigen receptor (CAR)-T cells has emerged as a potent immunotherapy against some hematological malignancies but not yet for epithelial-derived solid tumors. One critical issue is the paucity of broadly exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e19e79a1d07104a373c258551b711d
https://doi.org/10.1136/jitc-2020-002151
https://doi.org/10.1136/jitc-2020-002151