Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Giordano Reginato"'
Autor:
Tomoki Tamai, Giordano Reginato, Ryusei Ojiri, Issei Morita, Alexandra Avrutis, Petr Cejka, Miki Shinohara, Katsunori Sugimoto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract DNA double-strand breaks (DSBs) must be repaired to ensure cell survival and genomic integrity. In yeast, the Mre11-Rad50-Xrs2 complex (MRX) collaborates with Sae2 to initiate DSB repair. Sae2 stimulates two MRX nuclease activities, endonucl
Externí odkaz:
https://doaj.org/article/acbba23eb49746468174a70b6864e030
Autor:
Giordano Reginato, Maria Rosaria Dello Stritto, Yanbo Wang, Jingzhou Hao, Raphael Pavani, Michael Schmitz, Swagata Halder, Vincent Morin, Elda Cannavo, Ilaria Ceppi, Stefan Braunshier, Ananya Acharya, Virginie Ropars, Jean-Baptiste Charbonnier, Martin Jinek, Andrè Nussenzweig, Taekjip Ha, Petr Cejka
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The outcome of CRISPR-Cas-mediated genome modifications is dependent on DNA double-strand break (DSB) processing and repair pathway choice. Homology-directed repair (HDR) of protein-blocked DSBs requires DNA end resection that is initiated b
Externí odkaz:
https://doaj.org/article/9468f29a4c104f0db450028e4975e766
Autor:
Vera M. Kissling, Giordano Reginato, Eliana Bianco, Kristina Kasaciunaite, Janny Tilma, Gea Cereghetti, Natalie Schindler, Sung Sik Lee, Raphaël Guérois, Brian Luke, Ralf Seidel, Petr Cejka, Matthias Peter
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The Mre11-Rad50 (MR) complex has key functions in the detection, signaling and repair of DNA breaks. Here the authors use transmission electron microscopy to show MR oligomerization is governed by a small beta-sheet protruding from the head domain of
Externí odkaz:
https://doaj.org/article/3b0bb9efd9d04d24afb66624d538d569
Autor:
Antonio Marsella, Elisa Gobbini, Corinne Cassani, Renata Tisi, Elda Cannavo, Giordano Reginato, Petr Cejka, Maria Pia Longhese
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108906- (2021)
Summary: The Mre11-Rad50-Xrs2 (MRX) complex detects and processes DNA double-strand breaks (DSBs). Its DNA binding and processing activities are regulated by transitions between an ATP-bound state and a post-hydrolysis cutting state that is nucleolyt
Externí odkaz:
https://doaj.org/article/2daadc75ae19488e809716ef636b5a95
Autor:
Vincent Spegg, Andreas Panagopoulos, Merula Stout, Aswini Krishnan, Giordano Reginato, Ralph Imhof, Bernd Roschitzki, Petr Cejka, Matthias Altmeyer
Publikováno v:
Nature Structural & Molecular Biology, 30 (4)
RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is required for downstream ssDNA transactions. How ultrahigh-affinity binding and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ee80ab0e5b6daef7daa24ba376e915
Publikováno v:
Molecular Cell. 83:1237-1250.e15
Publikováno v:
Curr Opin Genet Dev
DNA breaks may arise accidentally in vegetative cells or in a programmed manner in meiosis. The usage of a DNA template makes homologous recombination potentially error-free, however, recombination is not always accurate. Cells possess a remarkable c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f065455f0282abe4ee7c1fa5a925134c
http://doc.rero.ch/record/333687/files/Cejka_coigd_2021.pdf
http://doc.rero.ch/record/333687/files/Cejka_coigd_2021.pdf
Autor:
Giordano Reginato, Sung Sik Lee, Janny Tilma, Vera M. Kissling, Petr Cejka, Ralf Seidel, Gea Cereghetti, Raphael Guerois, Eliana Bianco, Kristina Kasaciunaite, Matthias Peter
The conserved Mre11-Rad50 (MR) complex is crucial for the detection, signaling, end tethering and processing of DNA double-strand breaks (DSBs). While it was known for decades that MR foci formation at DSBs accompanies repair, the underlying molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985d2c97de693e99e52d5b7e070088a4
https://doi.org/10.21203/rs.3.rs-811984/v1
https://doi.org/10.21203/rs.3.rs-811984/v1
Autor:
Vera M, Kissling, Giordano, Reginato, Eliana, Bianco, Kristina, Kasaciunaite, Janny, Tilma, Gea, Cereghetti, Natalie, Schindler, Sung Sik, Lee, Raphaël, Guérois, Brian, Luke, Ralf, Seidel, Petr, Cejka, Matthias, Peter
Publikováno v:
Nature communications. 13(1)
The conserved Mre11-Rad50 complex is crucial for the detection, signaling, end tethering and processing of DNA double-strand breaks. While it is known that Mre11-Rad50 foci formation at DNA lesions accompanies repair, the underlying molecular assembl
Autor:
Swagata Halder, Aurore Sanchez, Lepakshi Ranjha, Giordano Reginato, Ilaria Ceppi, Ananya Acharya, Roopesh Anand, Petr Cejka
Publikováno v:
Molecular Cell. 82:3553-3565.e5
RAD51 and the breast cancer suppressor BRCA2 have critical functions in DNA double-strand (dsDNA) break repair by homologous recombination and the protection of newly replicated DNA from nucleolytic degradation. The recombination function of RAD51 re