Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Giordano Nicoletti"'
Autor:
Veronica Giusti, Francesca Ruzzi, Lorena Landuzzi, Marianna L. Ianzano, Roberta Laranga, Elena Nironi, Laura Scalambra, Giordano Nicoletti, Carla De Giovanni, Martina Olivero, Maddalena Arigoni, Raffaele Calogero, Patrizia Nanni, Arianna Palladini, Pier-Luigi Lollini
Publikováno v:
Oncogenesis, Vol 10, Iss 11, Pp 1-12 (2021)
Abstract HER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In this work, we studied cell lines derived from two transgenic mammary tumors driven by human HER2 that showed different dynamics of HER2 status. MamBo89HE
Externí odkaz:
https://doaj.org/article/b560bd2ffc044642b16dd92b9b06a0fa
Autor:
Lorena Landuzzi, Arianna Palladini, Claudio Ceccarelli, Sofia Asioli, Giordano Nicoletti, Veronica Giusti, Francesca Ruzzi, Marianna L. Ianzano, Laura Scalambra, Roberta Laranga, Tania Balboni, Maddalena Arigoni, Martina Olivero, Raffaele A. Calogero, Carla De Giovanni, Massimiliano Dall’Ora, Enrico Di Oto, Donatella Santini, Maria Pia Foschini, Maria Cristina Cucchi, Simone Zanotti, Mario Taffurelli, Patrizia Nanni, Pier-Luigi Lollini
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract We established patient-derived xenografts (PDX) from human primary breast cancers and studied whether stability or progressive events occurred during long-term in vivo passages (up to 4 years) in severely immunodeficient mice. While most PDX
Externí odkaz:
https://doaj.org/article/59a0895a37d34757859e7e9b853a7ad6
Autor:
Patrizia Nanni, Lorena Landuzzi, Maria Cristina Manara, Alberto Righi, Giordano Nicoletti, Camilla Cristalli, Michela Pasello, Alessandro Parra, Marianna Carrabotta, Manuela Ferracin, Arianna Palladini, Marianna L. Ianzano, Veronica Giusti, Francesca Ruzzi, Mauro Magnani, Davide Maria Donati, Piero Picci, Pier-Luigi Lollini, Katia Scotlandi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Standard therapy of osteosarcoma (OS) and Ewing sarcoma (EW) rests on cytotoxic regimes, which are largely unsuccessful in advanced patients. Preclinical models are needed to break this impasse. A panel of patient-derived xenografts (PDX) wa
Externí odkaz:
https://doaj.org/article/520fd06572ac4ed78a2083b0e3a1fa0d
Autor:
Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini, Pier-Luigi Lollini
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere with rhabdomyosarcom
Externí odkaz:
https://doaj.org/article/98c06761c44e458a8f112936ff488f59
Autor:
Carla De Giovanni, Lorena Landuzzi, Arianna Palladini, Giordano Nicoletti, Patrizia Nanni, Pier-Luigi Lollini
Publikováno v:
Cells, Vol 10, Iss 7, p 1808 (2021)
Rhabdomyosarcomas (RMS) are tumors of the skeletal muscle lineage. Two main features allow for distinction between subtypes: morphology and presence/absence of a translocation between the PAX3 (or PAX7) and FOXO1 genes. The two main subtypes are fusi
Externí odkaz:
https://doaj.org/article/12e4369e2c9b4f35a2d73d4015d16707
Autor:
Patrizia Nanni, Carla De Giovanni, Alessia Burocchi, Giordano Nicoletti, Lorena Landuzzi, Arianna Palladini, Marianna Lucia Ianzano, Ivano Arioli, Mario P. Colombo, Pier-Luigi Lollini
Publikováno v:
OncoImmunology, Vol 7, Iss 8 (2018)
This study evaluated the effects of combining an OX40 agonistic antibody (aOX40) with a cell vaccine targeting HER2/neu, called “Triplex”. Such HER2/neu cell vaccine included two biological adjuvants (interleukin 12 (IL12) and allogeneic histocom
Externí odkaz:
https://doaj.org/article/8eadcd7678204624bb8b5facf4a2c8b7
Autor:
Arianna Palladini, Susan Thrane, Christoph M. Janitzek, Jessica Pihl, Stine B. Clemmensen, Willem Adriaan de Jongh, Thomas M. Clausen, Giordano Nicoletti, Lorena Landuzzi, Manuel L. Penichet, Tania Balboni, Marianna L. Ianzano, Veronica Giusti, Thor G. Theander, Morten A. Nielsen, Ali Salanti, Pier-Luigi Lollini, Patrizia Nanni, Adam F. Sander
Publikováno v:
OncoImmunology, Vol 7, Iss 3 (2018)
Overexpression of human epidermal growth factor receptor-2 (HER2) occurs in 20–30% of invasive breast cancers. Monoclonal antibody therapy is effective in treating HER2-driven mammary carcinomas, but its utility is limited by high costs, side effec
Externí odkaz:
https://doaj.org/article/e1b993a0c5c5445cb0c1372cb80b222f
Autor:
Michela Pasello, Maria Cristina Manara, Francesca Michelacci, Marilù Fanelli, Claudia Maria Hattinger, Giordano Nicoletti, Lorena Landuzzi, Pier Luigi Lollini, Annamaria Caccuri, Piero Picci, Katia Scotlandi, Massimo Serra
Publikováno v:
Analytical Cellular Pathology, Vol 34, Iss 3, Pp 131-145 (2011)
Recent studies have indicated that targeting glutathione-S-transferase (GST) isoenzymes may be a promising novel strategy to improve the efficacy of conventional chemotherapy in the three most common musculoskeletal tumours: osteosarcoma, Ewing's sar
Externí odkaz:
https://doaj.org/article/8f625881f78f4c1e9ef28d978c521e8c
Autor:
Patrizia Nanni, Valentina Gatta, Laura Menotti, Carla De Giovanni, Marianna Ianzano, Arianna Palladini, Valentina Grosso, Massimiliano Dall'ora, Stefania Croci, Giordano Nicoletti, Lorena Landuzzi, Manuela Iezzi, Gabriella Campadelli-Fiume, Pier-Luigi Lollini
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003155 (2013)
Oncolytic viruses aim to specifically kill tumor cells. A major challenge is the effective targeting of disseminated tumors in vivo. We retargeted herpes simplex virus (HSV) tropism to HER-2 oncoprotein p185, overexpressed in ovary and breast cancers
Externí odkaz:
https://doaj.org/article/45fe9d4027634cfe86e1eaff9514f27a
Autor:
Patrizia Nanni, Giordano Nicoletti, Arianna Palladini, Stefania Croci, Annalisa Murgo, Marianna L Ianzano, Valentina Grosso, Valeria Stivani, Agnese Antognoli, Alessia Lamolinara, Lorena Landuzzi, Emmanuelle di Tomaso, Manuela Iezzi, Carla De Giovanni, Pier-Luigi Lollini
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39626 (2012)
In vivo studies of the metastatic process are severely hampered by the fact that most human tumor cell lines derived from highly metastatic tumors fail to consistently metastasize in immunodeficient mice like nude mice. We describe a model system bas
Externí odkaz:
https://doaj.org/article/84ef216e802b4cee8d005229b86ae354