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Akademický článek

Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate

Autor: Iris Baars, Moritz Jaedtka, Leon-Alexander Dewitz, Yan Fu, Tobias Franz, Juliane Mohr, Patricia Gintschel, Hannes Berlin, Angelina Degen, Sandra Freier, Stefan Rygol, Burkhart Schraven, Sascha Kahlfuß, Ger van Zandbergen, Andreas J. Müller

Publikováno v: JCI Insight, Vol 8, Iss 14 (2023)

The virulence of intracellular pathogens relies largely on the ability to survive and replicate within phagocytes but also on release and transfer into new host cells. Such cell-to-cell transfer could represent a target for counteracting microbial pa

Externí odkaz: https://doaj.org/article/50f6bbf74d0449dca586aefd281cb8f2

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Akademický článek

Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection

Autor: Corinna L. Kleinholz, Monika Riek-Burchardt, Elena A. Seiß, Jonas Amore, Patricia Gintschel, Lars Philipsen, Philippe Bousso, Borna Relja, Burkhart Schraven, Juliane Handschuh, Juliane Mohr, Andreas J. Müller

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Neutrophils represent one of the first immune cell types recruited to sites of infection, where they can control pathogens by phagocytosis and cytotoxic mechanisms. Intracellular pathogens such as Leishmania major can hijack neutrophils to e

Externí odkaz: https://doaj.org/article/f2456a9e704b4f9fa58aa4b2c68737f6

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Akademický článek

A Risk-Based Analysis of Design Practices in Regard to Passenger Hazard Exposure in Open Mass Transit Stations

Autor: Sebastian Gintschel, Phumin Kirawanich

Publikováno v: Urban Rail Transit, Vol 6, Iss 1, Pp 15-27 (2020)

Abstract Design practices in regard to passenger hazard exposure in mass transit stations that are directly open to the atmosphere, so-called open stations, are the focus of this study. The benchmarking exercise intends to provide a comprehensive rev

Externí odkaz: https://doaj.org/article/aeeab3142b374427853e001722401d15

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Akademický článek

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Akademický článek

CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission.

Autor: Sandrina Heyde, Lars Philipsen, Pauline Formaglio, Yan Fu, Iris Baars, Guido Höbbel, Corinna L Kleinholz, Elena A Seiß, Juliane Stettin, Patricia Gintschel, Anne Dudeck, Philippe Bousso, Burkhart Schraven, Andreas J Müller

Publikováno v: PLoS Pathogens, Vol 14, Iss 10, p e1007374 (2018)

The virulence of intracellular pathogens such as Leishmania major (L. major) relies largely on their ability to undergo cycles of replication within phagocytes, release, and uptake into new host cells. While all these steps are critical for successfu

Externí odkaz: https://doaj.org/article/c2d1ab9e830b4352b53632d7acddd8a8

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Akademický článek

Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice.

Autor: Matous Hrdinka, Kritika Sudan, Sissy Just, Ales Drobek, Ondrej Stepanek, Dirk Schlüter, Dirk Reinhold, Bryen A Jordan, Patricia Gintschel, Burkhart Schraven, Michael R Kreutz

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162863 (2016)

Transmembrane adaptor proteins (TRAPs) are important organisers for the transduction of immunoreceptor-mediated signals. Prr7 is a TRAP that regulates T cell receptor (TCR) signalling and potently induces cell death when overexpressed in human Jurkat

Externí odkaz: https://doaj.org/article/bbb679c5e2df474abed259812b0a0946

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