Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ginte Kutkaite"'
Autor:
Irineos Papakyriacou, Ginte Kutkaite, Marta Rúbies Bedós, Divya Nagarajan, Liam P. Alford, Michael P. Menden, Yumeng Mao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune checkpoint blockade therapy aims to activate the immune system to eliminate cancer cells. However, clinical benefits are only recorded in a subset of patients. Here, we leverage genome-wide CRISPR/Cas9 screens in a Tumor-Immune co-Cul
Externí odkaz:
https://doaj.org/article/b4b21ac099f0476298aa50b1eda1257e
Autor:
Alexander Joschua Ohnmacht, Anantharamanan Rajamani, Göksu Avar, Ginte Kutkaite, Emanuel Gonçalves, Dieter Saur, Michael Patrick Menden
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Aberrant DNA methylation accompanies genetic alterations during oncogenesis and tumour homeostasis and contributes to the transcriptional deregulation of key signalling pathways in cancer. Despite increasing efforts in DNA methylation profil
Externí odkaz:
https://doaj.org/article/594ca880fb51453786dbe5a78deee1f9
Autor:
Dennis Wang, James Hensman, Ginte Kutkaite, Tzen S Toh, Ana Galhoz, GDSC Screening Team, Jonathan R Dry, Julio Saez-Rodriguez, Mathew J Garnett, Michael P Menden, Frank Dondelinger
Publikováno v:
eLife, Vol 9 (2020)
High-throughput testing of drugs across molecular-characterised cell lines can identify candidate treatments and discover biomarkers. However, the cells’ response to a drug is typically quantified by a summary statistic from a best-fit dose-respons
Externí odkaz:
https://doaj.org/article/51d4ac80e399452ea2ade47a41995bd5
Autor:
Maryam Ghalandary, Yuqiao Gao, Diana Amend, Ginte Kutkaite, Binje Vick, Karsten Spiekermann, Maja Rothenberg-Thurley, Klaus H. Metzeler, Anetta Marcinek, Marion Subklewe, Michael P. Menden, Vindi Jurinovic, Ehsan Bahrami, Irmela Jeremias
Publikováno v:
Blood 141, 955-960 (2023)
Autor:
Michael P. Menden, Howard Lightfoot, William J. Barendt, Ermira Lleshi, Wanjuan Yang, Dennis Wang, Syd Barthorpe, Jonathan R. Dry, Tzen S. Toh, Julio Saez-Rodriguez, Ginte Kutkaite, James Hensman, Gdsc Screening Team, Maryam Soleimani, James Hall, Tatiana Mironenko, Laura Richardson, Charlotte Tolley, Ana Galhoz, Alexandra Beck, Frank Dondelinger, Mathew J. Garnett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f14859b62cec91d09bad597d00c0f6cf
https://doi.org/10.7554/elife.60352.sa2
https://doi.org/10.7554/elife.60352.sa2
Autor:
Michael P. Menden, Richa Batra, Carsten B. Schmidt-Weber, Stefanie Eyerich, Alexander Böhner, Alexander Schäbitz, Tilo Biedermann, Nikola Müller, J. Thomas, Peter Seiringer, Natalie Garzorz-Stark, Ginte Kutkaite, Caroline Pilz, Kilian Eyerich, Sophie Roenneberg, Lam C. Tsoi, Bentolhoda Fereydouni, Johann E. Gudjonsson, F. Lauffer, M. Jargosch, Fabian Theis F
Chronic inflammatory diseases are characterized by complex interactions between genetic predisposition and tissue-specific immune responses. This heterogeneity complicates diagnoses and the ability to exploit omics approaches to improve disease manag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac26c553357cda05e9488f60cbd8bd6b
https://doi.org/10.1101/2020.07.25.221309
https://doi.org/10.1101/2020.07.25.221309