Prognostic significance of soluble PD-L1 in prostate cancer

Autor: Margarita Zvirble, Zilvinas Survila, Paulius Bosas, Neringa Dobrovolskiene, Agata Mlynska, Gintaras Zaleskis, Jurgita Jursenaite, Dainius Characiejus, Vita Pasukoniene

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

PurposeThe aim of this study was to assess the role of sPD-L1 and sPD-1 as potential biomarkers in prostate cancer (PCa). The association of the values of these soluble proteins were correlated to the clinical data: stage of disease, Gleason score, b

Externí odkaz: https://doaj.org/article/a2bc41903f2d4f8b8d23db8de4ac5a45

Do the benefits of being a smoker hint at the existence of PD-1/PD-L1 sensitizers for patients on single-agent immunotherapy?

Autor: Vincas Urbonas, Gintaras Zaleskis, Vita Pasukoniene, Dainius Characiejus

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)

Multiple studies demonstrate significantly better therapeutics outcomes in smokers as compared with never smokers when single-agent immunotherapy is applied. Non-smoker patients usually need a combination of chemoimmunotherapy to achieve comparable o

Externí odkaz: https://doaj.org/article/801eeb59169649f08691461930747ccd

Atezolizumab Retains Cellular Binding to Programmed Death Ligand 1 Following AerosolizationviaMesh Nebulizer

Autor: GINTARAS ZALESKIS, MARTYNAS TALAIKIS, DAINIUS CHARACIEJUS, VINCAS URBONAS, PAULIUS BOSAS, ADAS DARINSKAS, LAVIJA ZIBUTYTE, LUKAS SIMKUS, ZILVINAS SURVILA, JURGITA JURSENAITE, MARGARITA ZVIRBLE

Publikováno v: Anticancer Research. 43:1065-1072

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f20fcc411dbb17678622f2363343e50
https://doi.org/10.21873/anticanres.16251

A Refinement of Clinical Tumor Marker Monitoring: Why Not Use an Inverse Value of Doubling Time?

Autor: Bret Andrew Hudson, Albertas Ulys, Paulius Bosas, Gintaras Zaleskis, Vita Pasukoniene, Daiva Dabkeviciene, Neringa Dobrovolskiene

Publikováno v: Med Princ Pract
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, Basel : Karger, 2021, vol. 30, iss. 3, p. 292-296

Objectives: The aim of this study was to compare prostate-specific antigen (PSA) kinetics – half-life time (HT), doubling time (DT), and elimination rate PSA (ePSA) in prostate cancer (PCa) monitoring. Implementation of ePSA in clinical practice co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d53077b8856df4fbe82361cffda14d0
https://doi.org/10.1159/000515977

Thymus Subset Alterations Accompanying Concomitant Tumor Immunity Mimics Phenotypic Patterns of Cytotoxic Drug Doxorubicin

Autor: GINTARAS ZALESKIS, DAINIUS CHARACIEJUS, JURGITA JURSENAITE, LAVIJA ZIBUTYTE, KAROLINA KRIAUCIUNAITE, MILDA VANAGAITE-ZICKIENE, ADAS DARINSKAS, MANTAS JONUSIS, VITA PASUKONIENE

Publikováno v: In Vivo
In vivo, Athens : NLM (Medline), 2022, vol. 36, iss. 3, p. 1106-1113

Background/Aim: Concomitant immunity (CIM) is a phenomenon that elicits an antitumor response not sufficient enough to destroy the primary tumor but prevents a secondary implant from growing and spreading. This study aimed to develop a method of iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc622a2336847d3ecdd8c14be9404b2
https://europepmc.org/articles/PMC9087100/