Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ginson, George"'
Autor:
Reshma Susan Ipe, Sunil Kumar, Feba Benny, Jayalakshmi Jayan, Amritha Manoharan, Sachitra Thazhathuveedu Sudevan, Ginson George, Prashant Gahtori, Hoon Kim, Bijo Mathew
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1310 (2023)
Monoamine oxidases (MAOs) are a family of flavin adenine dinucleotide-dependent enzymes that catalyze the oxidative deamination of a wide range of endogenous and exogenous amines. Multiple neurological conditions, including Parkinson’s disease (PD)
Externí odkaz:
https://doaj.org/article/580afb4f36c04730a8527fe4c7ce4dce
Autor:
Babitha Thekkiniyedath Dharmapalan, Raja Biswas, Sathianarayanan Sankaran, Baskar Venkidasamy, Muthu Thiruvengadam, Ginson George, Maksim Rebezov, Gokhan Zengin, Monica Gallo, Domenico Montesano, Daniele Naviglio, Mohammad Ali Shariati
Publikováno v:
Viruses, Vol 14, Iss 12, p 2656 (2022)
Dengue fever is a mosquito-borne viral disease that has become a serious health issue across the globe. It is caused by a virus of the Flaviviridae family, and it comprises five different serotypes (DENV-1 to DENV-5). As there is no specific medicine
Externí odkaz:
https://doaj.org/article/7ef4cf00d04740f493d1121dc6178a37
Structural Modifications on Chalcone Framework for Developing New Class of Cholinesterase Inhibitors
Autor:
Ginson George, Vishal Payyalot Koyiparambath, Sunitha Sukumaran, Aathira Sujathan Nair, Leena K. Pappachan, Abdullah G. Al-Sehemi, Hoon Kim, Bijo Mathew
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3121 (2022)
Due to the multifaceted pharmacological activities of chalcones, these scaffolds have been considered one of the most privileged frameworks in the drug discovery process. Structurally, chalcones are α, β-unsaturated carbonyl functionalities with tw
Externí odkaz:
https://doaj.org/article/a7fca4d9642442ccb9f744f2b64c88b4
Autor:
Sridhar, S.N.C., Ginson, George, Venkataramana Reddy, P.O., Tantak, Mukund P., Kumar, Dalip, Paul, Atish T.
Publikováno v:
In Bioorganic & Medicinal Chemistry 15 January 2017 25(2):609-620
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a700fddab2e299d9371b00a7ba283217
https://doi.org/10.1080/07391102.2022.2144456
https://doi.org/10.1080/07391102.2022.2144456
Publikováno v:
Letters in Drug Design & Discovery. 19:956-968
Background: Obesity is a multifactorial metabolic disease characterised by excessive accumulation of triglycerides. The prevalence and morbidity rates associated with obesity are increasing tremendously, posing a significant risk to society. Pancreat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6704365e041d140e721209622c95b3f2
https://doi.org/10.2174/1570180819666220314094820
https://doi.org/10.2174/1570180819666220314094820
Autor:
Anusree Venkidath, Jong Min Oh, Sanal Dev, Elham Amin, Shebina P. Rasheed, Ajeesh Vengamthodi, Nicola Gambacorta, Ahmed Khames, Mohamed A. Abdelgawad, Ginson George, Orazio Nicolotti, Hoon Kim, Bijo Mathew
Publikováno v:
Molecules, Vol 26, Iss 19, p 6004 (2021)
A small series of nitro group-bearing enamides was designed, synthesized (NEA1–NEA5), and evaluated for their inhibitory profiles of monoamine oxidases (MAOs) and β-site amyloid precursor protein cleaving enzyme 1 (β-secretase, BACE1). Compounds
Externí odkaz:
https://doaj.org/article/4a8c83f6538c49de905897cb6b8edc72
Purpose COVID-19 pandemic has become worse with the difficulty of tracing the virus or phase of the coronaviral cycle inside the host, the failure of currently employed drugs over a vast population and the evolution of newer multiple strains. This wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6155f28642610dce23203f41b258cfd0
https://doi.org/10.21203/rs.3.rs-2581375/v1
https://doi.org/10.21203/rs.3.rs-2581375/v1
Autor:
Pracheta Sengupta, Sridhar S.N.C., Ginson George, Atish T. Paul, Saksham Palawat, Dileep P. S
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:9530-9542
Pancreatic lipase is a digestive enzyme involved in the hydrolysis of dietary fats. Orlistat, a potent pancreatic lipase inhibitor, is widely prescribed for long-term obesity treatment. Nevertheless, orlistat is reported for severe adverse effects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abca1bc795f2773f72ebae45c2c7be8
https://doi.org/10.1080/07391102.2021.1930168
https://doi.org/10.1080/07391102.2021.1930168
Publikováno v:
New Journal of Chemistry. 45:1381-1394
Pancreatic lipase (PL) is a key enzyme responsible for the digestion of dietary triglycerides; hence its inhibition is considered as a promising target for the management and/or treatment of obesity. A new series of indole-thiazolidinedione (TZD) hyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d5060ca0f8f9f616be0568cb84308dc
https://doi.org/10.1039/d0nj05649a
https://doi.org/10.1039/d0nj05649a