Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis

Autor: Jennifer Venhorst, Roeland Hanemaaijer, Remon Dulos, Martien P. M. Caspers, Karin Toet, Joline Attema, Christa de Ruiter, Gino Kalkman, Tanja Rouhani Rankouhi, Jelle C. B. C. de Jong, Lars Verschuren

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

An in silico target discovery pipeline was developed by including a directional and weighted molecular disease network for metabolic dysfunction-associated steatohepatitis (MASH)-induced liver fibrosis. This approach integrates text mining, network b

Externí odkaz: https://doaj.org/article/2ed7e1d7d253401ab02b8a54abdd0c8d

Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery

Autor: Astrid A.T.M. Bosch, Evgeni Levin, Marlies A. van Houten, Raiza Hasrat, Gino Kalkman, Giske Biesbroek, Wouter A.A. de Steenhuijsen Piters, Pieter-Kees C.M. de Groot, Paula Pernet, Bart J.F. Keijser, Elisabeth A.M. Sanders, Debby Bogaert

Publikováno v: EBioMedicine, Vol 9, Iss C, Pp 336-345 (2016)

Birth by Caesarian section is associated with short- and long-term respiratory morbidity. We hypothesized that mode of delivery affects the development of the respiratory microbiota, thereby altering its capacity to provide colonization resistance an

Externí odkaz: https://doaj.org/article/44a01b674f5f403e8ae8594f668a2b2d

81 Traac Framework and tool for Regulatory Acceptance and Wider Usability of Tools/Methods for safe Innovation and Sustainability of Nanomaterials

Autor: Neeraj Shandilya, Marie-Sophie Barreau, Blanca Suarez-Merino, Andrea Porcari, Daniela Pimponi, Keld Jensen, Susan Dekkers, Wouter Fransman, Gino Kalkman, Marlies Otto, Eugene van Someren, Remy Franken

Publikováno v: Annals of Work Exposures and Health. 67:i82-i83

There has been an increasing use of manufactured nanomaterials in industrial applications and consumer products. It has instigated concerns about the sustainability, risks and uncertainties regarding the interactions of the nanomaterials with humans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99c2174f663014ed1e866d7008ef4b3d
https://doi.org/10.1093/annweh/wxac087.201

Development of the gut microbiota in early life: The impact of cystic fibrosis and antibiotic treatment

Autor: Maartje I Kristensen, Gerdien A. Tramper-Stranders, Bert Arets, Hettie M. Janssens, Cornelis K. van der Ent, Elisabeth A. M. Sanders, H.A.W.M. Tiddens, Debby Bogaert, Mireille van Westreenen, Raiza Hasrat, Gino Kalkman, Bart J. F. Keijser, Karin M. de Winter-de Groot, Sabine M. P. J. Prevaes

Publikováno v: Journal of Cystic Fibrosis, 19(4), 553-561. Elsevier

Patients with Cystic Fibrosis (CF) suffer from pancreatic insufficiency, lipid malabsorption and gastrointestinal complaints, next to progressive pulmonary disease. Altered mucosal homoeostasis due to malfunctioning chloride channels results in an ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be5753a62f1d7b9653a063972cc7486
https://doi.org/10.1016/j.jcf.2020.04.007

Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery

Autor: Paula Pernet, Giske Biesbroek, Evgeni Levin, Astrid A. T. M. Bosch, Raiza Hasrat, Marlies A. van Houten, Bart J. F. Keijser, Wouter A. A. de Steenhuijsen Piters, Elisabeth A. M. Sanders, Pieter-Kees C. M. de Groot, Gino Kalkman, Debby Bogaert

Publikováno v: EBIOMEDICINE, 9, 336-345. Elsevier
Bosch, A A T M, Levin, E, van Houten, M A, Hasrat, R, Kalkman, G, Biesbroek, G, de Steenhuijsen Piters, W A A, de Groot, P-K C M, Pernet, P, Keijser, B J F, Sanders, E A M & Bogaert, D 2016, ' Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery ', EBioMedicine, vol. 9, pp. 336-45 . https://doi.org/10.1016/j.ebiom.2016.05.031
Bosch, A A T M, Levin, E, van Houten, M A, Hasrat, R, Kalkman, G, Biesbroek, G, de Steenhuijsen Piters, W A A, de Groot, P-KCM, Pernet, P, Keijser, B J F, Sanders, E A M & Bogaert, D 2016, ' Development of upper respiratory tract microbiota in infancy is affected by mode of delivery ', Ebiomedicine, vol. 9, pp. 336-345 . https://doi.org/10.1016/j.ebiom.2016.05.031
EBioMedicine
Ebiomedicine, 9, 336-345. Elsevier BV
EBioMedicine, Vol 9, Iss C, Pp 336-345 (2016)

Birth by Caesarian section is associated with short- and long-term respiratory morbidity. We hypothesized that mode of delivery affects the development of the respiratory microbiota, thereby altering its capacity to provide colonization resistance an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fac794b5dfa3972b0ee09404169780
https://doi.org/10.1016/j.ebiom.2016.05.031