Výsledky vyhledávání - "Gino J, Sasso"

Metabolism of selective 20-epi-vitamin D3 analogs in rat osteosarcoma UMR-106 cells: Isolation and identification of four novel C-1 fatty acid esters of 1α,25-dihydroxy-16-ene-20-epi-vitamin D3

Autor: A. Weiskopf, Milan R. Uskokovic, Matthew K. Robinson, Gino J. Sasso, G. Satyanarayana Reddy, Caroline C. Flarakos, Guoshun Wang, Paul Vouros

Publikováno v: Steroids. 119:18-30

Analogs of 1α,25-dihydroxyvitamin D3 (S1) with 20-epi modification (20-epi analogs) possess unique biological properties. We previously reported that 1α,25-dihydroxy-20-epi-vitamin D3 (S2), the basic 20-epi analog is metabolized into less polar met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0890c346c0c9b50055d19c181fe6cf40
https://doi.org/10.1016/j.steroids.2016.12.013

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1α,25-Dihydroxy-16-ene-23-yne-vitamin D3 and 1α,25-Dihydroxy-16-ene-23-yne-20-epi-vitaminD3: Analogs of 1α,25-Dihydroxyvitamin D3 That Resist Metabolism through the C-24 Oxidation Pathway Are Metabolized through the C-3 Epimerization Pathway

Autor: Norbert Astecker, D.Sunita Rao, Paul Vouros, Gino J. Sasso, Mei-Ling Siu-Caldera, Milan R. Uskokovic, Percy S. Manchand, A. Weiskopf, G. Satyanarayana Reddy

Publikováno v: Archives of Biochemistry and Biophysics. 383:197-205

The secosteroid hormone 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] is metabolized in its target tissues through modifications of both the side chain and the A-ring. The C-24 oxidation pathway, the previously well established main side chain mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bfdcedb4c00fee8f2da4814bc38c4b
https://doi.org/10.1006/abbi.2000.2074

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Synthesis and evaluation of retinal Schiff base salts and related compounds as radar absorbing agents

Autor: Thomas H. Williams, Wayne S. Hammond, Thomas R. Wagler, David L. Coffen, Gino J. Sasso, Voldemar Toome, Larry E. Nitzsche, Eugene Ho, Carlo Nocka

Publikováno v: Journal f�r Praktische Chemie/Chemiker-Zeitung. 335:135-142

Thirteen Schiff base salts in the class of compounds represented by retinal pyrrolidinium perchlorate were prepared (most of them for the first time), fully characterized analytically and spectroscopically, and examined in the 30–100 GHz range with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c880f5bc6147ef89b95a809b77a9ed0
https://doi.org/10.1002/prac.19933350204

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Stereoselective synthesis of (24R and 24S) 5β-cholestane-3α,7α,12α,24,25-pentols and (25R and 25S) 5β-cholestane 3α,7α,12α,25,26-pentols using a modified osmium-catalyzed Sharpless asymmetric dihydroxylation process

Autor: G.S. Tint, Gerald Salen, Sarah Shefer, Gino J. Sasso, B. Dayal, J. Padia, Thomas H. Williams, Voldemar Toome

Publikováno v: Chemistry and Physics of Lipids. 61:271-281

Described herein are the stereoselective syntheses of the (24 R , 24 S ) and (25 R , 25 S ) isomers of 5β-cholestane-3α,7α,12α,24,25-pentols and 5β-cholestane-3α,7α,12α,25,26-pentols by using a modified osmium-catalyzed Sharpless asymmetric d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f212c660a388e13c3006177c581a5c7
https://doi.org/10.1016/0009-3084(92)90107-z

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Isolation and identification of 1alpha-hydroxy-3-epi-vitamin D3, a potent suppressor of parathyroid hormone secretion

Autor: A. Weiskopf, Paul Vouros, G. Satyanarayana Reddy, Alex J. Brown, Milan R. Uskokovic, Cynthia S. Ritter, Guochun Wang, Gino J. Sasso

Publikováno v: Journal of cellular biochemistry. 96(3)

Since our original demonstration of the metabolism of 1alpha,25(OH)2D3 into 1alpha,25(OH)2-3-epi-D3 in human keratinocytes, there have been several reports indicating that epimerization of the 3 hydroxyl group of vitamin D compounds is a common metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e830b2ea4f5912d10866578180e2776b
https://pubmed.ncbi.nlm.nih.gov/16088954

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Microbial products. II. Granaticinic acid, a new antibiotic from a thermophilic streptomycete

Autor: Hubert Maehr, Joanne Smallheer, Thomas H. Williams, Julius Berger, Hilda V. Cuellar, Gino J. Sasso

Publikováno v: Monatshefte f�r Chemie. 110:531-540

Streptomyces sp. XT-11989 produces a mixture of two antibiotics with litmus-like indicator properties. One of them was shown to be identical with granaticin, the other was identified as [1S,3S,4S,7R,9R,10S,13R]-4,7,9,10-tetrahydro-5,12-dioxo-4, 6,10,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69941bea2e4f0be2834b48f36f4067fe
https://doi.org/10.1007/bf00938358

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Biotransformation of [14C]midazolam in the ratin vitroandin vivo

Autor: Thomas H. Williams, Stanley J. Kolis, Gino J. Sasso, Grace K. Woo, Morton A. Schwartz, Dolores Warinsky

Publikováno v: Xenobiotica. 11:373-384

1. Aerobic incubation of the maleate salt of midazolam, 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, with rat liver 9000 g supernatant fluid fortified with an NADPH-generating system yielded three metabolites. These were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1b5a3b99181124bd6206318d5e3a47
https://doi.org/10.3109/00498258109045848

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Synthesis of (+)-negamycin from D-glucose

Autor: Manfred Weigele, Gino J. Sasso, Silvano De Bernardo, John P. Tengi

Publikováno v: Tetrahedron Letters. 29:4077-4080

The broad spectrum antibiotic (+)-negamycin (1) was prepared from 1,2-O-isopropylidene- d -glucose ( 3 ) in nine steps.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::859f7a70ef0c3de5ee007650b486bf1e
https://doi.org/10.1016/s0040-4039(00)80421-9

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