Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Gino Doria"'
Publikováno v:
Clinical and Developmental Immunology, Vol 10, Iss 1, Pp 13-17 (2003)
CTLA-4 deficient mice show severe lymphoproliferative disorders with T helper sub-population skewed toward the Th2 phenotype. In the present work, we investigated the role of CTLA-4 in T helper cell subset differentiation. Naïve CD4+ cells were stim
Externí odkaz:
https://doaj.org/article/cd611b6e92fa470aa827610a8328bb09
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 82, Pp 9-13 (1987)
Externí odkaz:
https://doaj.org/article/0ad6423c1b954cad8f44b5eb4d0574fb
Publikováno v:
Immunology. 117:358-367
Naive CD4+ T-cell differentiation to T helper 1 (Th1) and Th2 cells is dependent on T-bet and GATA-3 factors, respectively. T-bet and GATA-3, indeed, through chromatin remodelling allow transcriptional activation of Ifngamma and Th2 cytokine (Il4, Il
Autor:
Lucia Gatta, Gino Doria, Giuseppe Fedeli, P. Balistreri, M. Ciarniello, M. Costanzo, Giovanni Gasbarrini, I. De Vitis, Luigia Pace, Carlo Bartoloni, Claudio Pioli, L. Coppola, A. Tricerri, Luisa Guidi
Publikováno v:
Scopus-Elsevier
The treatment with infliximab is employed successfully in Crohn's disease (CD) but predictors of efficacy are lacking. Activation of the transcription factor NF-kB has been demonstrated in CD and its inhibition is one of the mechanisms by which anti-
Publikováno v:
Ageing Research Reviews. 3:143-151
The genetic factors that determine immune responsiveness and DNA repair capacity are reviewed as major elements influencing the life span. Within this framework two sets of new data obtained in mice and humans are reported and discussed. As to the fi
Autor:
Vanessa Ubaldi, Fiorella Di Nicuolo, Gino Doria, Lucia Gatta, Luigia Pace, Claudio Pioli, Gabriella Calviello
Publikováno v:
Immunology. 107:209-216
The negative role exerted by cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in the regulation of T-cell activity, as induced by T-cell receptor (TCR)/CD3 and CD28 costimulation, has been widely described. In the present work we investigated the
Autor:
Carlo Bartoloni, Paola Barattini, Salvatore Scarpaci, Gino Doria, M. Costanzo, Luisa Guidi, Daniela Frasca
Publikováno v:
Experimental Gerontology. 37:321-328
Ku, composed of 70 kDa (ku 70) and 86 kDa (ku 80) proteins, is the DNA-targeting subunit of the DNA-dependent serine/threonine kinase (DNA-PK), which plays a crucial role in DNA double strand break recognition and repair in mammalian cells. We have i
Autor:
Daniela Frasca, Gino Doria
Publikováno v:
Vaccine. 18:1591-1595
Maximum life span is controlled by genes that regulate molecular mechanisms accounting for the synchrony of structural and functional changes in different cells and tissues of each member of a given species. The role of immune response genes was inve
Publikováno v:
British Journal of Haematology. 106:317-324
Sublethally irradiated mice were injected with recombinant cytokines to stimulate haemopoietic reconstitution. Interleukin (IL)-11 and IL-6 were able to significantly accelerate the recovery of thymus, spleen and bone marrow cells when used in combin
Autor:
Carlo Bartoloni, A. Tricerri, Paola Barattini, M. Costanzo, Daniela Frasca, Luca Pierelli, Gino Doria, Donatella Tirindelli, A.R. Errani, Luisa Guidi
Publikováno v:
Experimental Gerontology. 34:645-658
DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20–89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an