Výsledky vyhledávání - "Gino Castriota"

Akademický článek

A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis.

Autor: Ruojing Yang, Raul G Lacson, Gino Castriota, Xiaohua D Zhang, Yaping Liu, Wenqing Zhao, Monica Einstein, Luiz Miguel Camargo, Sajjad Qureshi, Kenny K Wong, Bei B Zhang, Marc Ferrer, Joel P Berger

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36384 (2012)

BACKGROUND: Hepatic insulin resistance impairs insulin's ability to suppress hepatic glucose production (HGP) and contributes to the development of type 2 diabetes (T2D). Although the interests to discover novel genes that modulate insulin sensitivit

Externí odkaz: https://doaj.org/article/dc77186e4c9b4cc6b48d81bd70229d6c

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Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits

Autor: Xinkang Wang, Dietmar Seiffert, Kenneth P. Ellsworth, Mark D. Erion, Xueping Zhou, Patrick Andre, Amjad Ali, Gino Castriota, Scott D. Edmondson, Stan Kurowski, David E. Gutstein, Zhu Chen, Donald Chu, Weizhen Wu, Lin Chu

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 360:476-483

Factor XI (FXI) is an integral component of the intrinsic pathway of the coagulation cascade and plays a critical role in thrombus formation. Because its role in the pathogenesis of cerebral microembolic signals (MES) is unclear, this study used a po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb6f4efc77b882cdf123fcb2b15ca6a
https://doi.org/10.1124/jpet.116.238600

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Differential anti-thrombotic benefit and bleeding risk profiles of antagonists of protease-activated receptor 1 and 4 in Cynomolgus Macaques

Autor: Steven Fried, L. Alexandra Wickham, Andrea D. Basso, Xinkang Wang, Lin Chu, Gary R. Sitko, Jason E. Imbriglio, Joseph M. Metzger, Karen Owens, Maria Maderia, Gino Castriota, Tian-Quan Cai, Maria Stranieri-Michener, Zhu Chen, Larry Handt

Publikováno v: Thrombosis Research. 145:133-139

Platelet activation plays a crucial role in hemostasis and thrombosis. Thrombin, the most potent stimulus of platelet activation, mediates platelet activation via the protease activated receptors (PARs). The platelet PAR repertoire in mediating throm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cc57d3496b4eef8d261c36432a307c
https://doi.org/10.1016/j.thromres.2016.06.007

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Factor XIIa as a Novel Target for Thrombosis: Target Engagement Requirement and Efficacy in a Rabbit Model of Microembolic Signals

Autor: Xinkang Wang, Dietmar Seiffert, Aimie M. Ogawa, Kim O’Neill, Xueping Zhou, Zhu Chen, Christopher M. Barbieri, David E. Gutstein, Weizhen Wu, Gino Castriota, Donald Chu

Publikováno v: The Journal of pharmacology and experimental therapeutics. 360(3)

Coagulation Factor XII (FXII) plays a critical role in thrombosis. What is unclear is the level of enzyme occupancy of FXIIa that is needed for efficacy and the impact of FXIIa inhibition on cerebral embolism. A selective activated FXII (FXIIa) inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd024940e3436d99cf23b96edf33dfad
https://pubmed.ncbi.nlm.nih.gov/28035006

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Abstract 523: Factor XIIa: New Insights on Chemical Tractability and Target Indications From a Potent and Selective Tool Inhibitor

Autor: Weizhen Wu, Xinkang Wang, Gino Castriota, David E. Gutstein, Aimie M. Ogawa, Xueping Zhou, Dietmar Seiffert, Christopher M. Barbieri, Zhu Chen, Kim O'Neil

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 36

FXII is an emerging target for thrombosis, yet several questions remain to be addressed. Firstly, from drug discovery perspective, level of enzyme occupancy needed for efficacy (which largely dictates potency and selectivity requirement for small mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7bbb964523aa27eb1733887bb43d52a
https://doi.org/10.1161/atvb.36.suppl_1.523

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Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization

Autor: Taro E. Akiyama, Qing Dallas-Yang, Marc Ferrer, Paul A. Fischer, Bei B. Zhang, Franklin Liu, Guoqiang Jiang, Gino Castriota, Jing Li, Joel P. Berger, Francesca Santini

Publikováno v: Biochemical Journal. 418:413-420

GLUT4 (glucose transporter 4) plays important roles in glucose homoeostasis in vivo. GLUT4 expression and function are diminished in diabetic human and animal subjects. The goal of the present study is to develop a cell-based assay for identifying ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2876dd05bdc81ef854a27bd866792e38
https://doi.org/10.1042/bj20082051

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The Differential Interactions of Peroxisome Proliferator-Activated Receptor γ Ligands with Tyr473 Is a Physical Basis for Their Unique Biological Activities

Autor: Harold B. Wood, Monica Einstein, Taro E. Akiyama, Joseph W. Becker, Peter T. Meinke, Joel P. Berger, Chuanlin F. Wang, Brian M. McKeever, Gino Castriota, Ralph T. Mosley, David E. Moller

Publikováno v: Molecular Pharmacology. 73:62-74

Despite their proven antidiabetic efficacy, widespread use of peroxisome proliferator-activated receptor (PPAR)gamma agonists has been limited by adverse cardiovascular effects. To overcome this shortcoming, selective PPARgamma modulators (SPPARgamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89a57730ac5b84482512bdee574b0b8
https://doi.org/10.1124/mol.107.041202

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Peroxisome proliferator-activated receptor γ agonists inhibit adipocyte expression of α1-acid glycoprotein

Autor: Ying Lin, G. Marie Thompson, Joel P. Berger, David E. Moller, Philipp E. Scherer, Gino Castriota

Publikováno v: Cell Biology International. 31:586-591

alpha1-Acid glycoprotein (alpha1-AGP) is an acute phase protein that can potentiate cytokine secretion by mononuclear cells and may induce thrombosis by stabilizing the inhibitory activity of plasminogen activator inhibitor-1. Thus, alpha1-AGP may pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfebf5104d4183fe27239080f8ca9a7
https://doi.org/10.1016/j.cellbi.2006.11.033

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Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit

Autor: John Cook, Yiming Xu, Dietmar Seiffert, Zhu Chen, Nina Jochnowitz, Joseph M. Metzger, Martin L. Ogletree, Gino Castriota, Christopher Loewrigkeit, Lizbeth M. Hoos, Yuchen Zhou, Tian-Quan Cai, Alexandra Wickham

Publikováno v: Thrombosis and haemostasis. 111(4)

SummaryCoagulation factor XII (FXII) plays a central role in initiating the intrinsic cascade of blood coagulation. Purified recombinant Human Albumin- tagged Infestin-4 (rHA-Infestin-4) is a recently described FXIIa inhibitor that displayed strong a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dff38a521aa8474d5ec5f77bc3f1897
https://pubmed.ncbi.nlm.nih.gov/24336918

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Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators

Publikováno v: Journal of medicinal chemistry. 54(24)

A series of benzimidazolone carboxylic acids and oxazolidinediones were designed and synthesized in search of selective PPARγ modulators (SPPARγMs) as potential therapeutic agents for the treatment of type II diabetes mellitus (T2DM) with improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9624198b46c222d0e4054ed24757c02a
https://pubmed.ncbi.nlm.nih.gov/22070604

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