Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Gino A, Kurian"'
Does cardiac impairment develop in ischemic renal surgery in rats depending on the reperfusion time?
Autor:
Priyanka N. Prem, Gino A. Kurian
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e31389- (2024)
Background: Renal dysfunction is known to cause heart failure. However, renal dysfunction associated with kidney surgeries (mediated by reperfusion injury) that affects the cardiac physiological function, especially during the recovery and repair pha
Externí odkaz:
https://doaj.org/article/5a8301247d4149708915296e30738985
Autor:
Priyanka N. Prem, Gino A. Kurian
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e22273- (2023)
Renal ischemia-reperfusion (IR) injury inflicts remote cardiac dysfunction. Studies on rats fed with a high-fat diet (HD) showed contradictory results: some demonstrated increased sensitivity of the heart and kidney to IR injury, while others reporte
Externí odkaz:
https://doaj.org/article/708148c30f2b4617a99b7f26315c810a
Publikováno v:
Life, Vol 13, Iss 11, p 2234 (2023)
GSK3β is a promising target for treating various disease conditions, including myocardial ischemia–reperfusion injury (IR). This study investigated the potential of GSK3β as a novel drug for managing IR in rats exposed to PM2.5 for 1 day and up t
Externí odkaz:
https://doaj.org/article/4552a27d02ad4145a75b886eeb588c26
Autor:
Sri Rahavi Boovarahan, Nemat Ali, Abdullah F. AlAsmari, Alaa Alnoor Alameen, Rehan Khan, Gino A. Kurian
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Most pre-clinical studies in cardiac ischemia-reperfusion injury (I/R) are carried out in young or old animals, which does not cater to the adult age in humans who encounter I/R. Not many studies in the literature are available that emphasize the sen
Externí odkaz:
https://doaj.org/article/2bc0732eef73438eaa1a31d823260631
Publikováno v:
Cells, Vol 12, Iss 16, p 2064 (2023)
Circulatory GSK3β is recognized as a biomarker and therapeutic target for diseases, including myocardial diseases. However, its potential as a target for myocardial ischemia-reperfusion injury (IR) in the presence of PM2.5 exposure is unclear. Wista
Externí odkaz:
https://doaj.org/article/2059703cc23740a78198a00dc2498161
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Ischemia reperfusion (I/R) injury is one of the main clinical challenges for cardiac surgeons. No effective strategies or therapy targeting the molecular and cellular mechanisms to reduce I/R exists to date, despite altered gene expression and cellul
Externí odkaz:
https://doaj.org/article/57c01e9a06174b848853bc3b9bd2c8dc
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 7, Pp 333-340 (2020)
Objective: To compare the anti-proliferative effect of sodium thiosulfate on human colorectal cancer cells (HT-29) and normal small intestine cells (IEC6). Methods: Cells (HT-29 and IEC6) were treated with different concentrations of sodium thiosulfa
Externí odkaz:
https://doaj.org/article/277a907acfb74206af3535c4cf0e4e2c
Publikováno v:
Biology, Vol 11, Iss 12, p 1811 (2022)
A previous study has reported that exposure to PM2.5 from diesel exhaust (diesel particulate matter (DPM)) for 21 days can deteriorate the cardiac recovery from myocardial ischemia reperfusion injury (IR), where the latter is facilitated by the effic
Externí odkaz:
https://doaj.org/article/b5331edf55d548809f4bf1adffc9db33
Autor:
Sri Rahavi Boovarahan, David Raj Chellappan, Nemat Ali, Abdullah F. AlAsmari, Mohammad Waseem, Abdullah Saad Alabdulrahim, Ziyad Ali Alzahrani, Gino A. Kurian
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3065 (2022)
A recent study has shown that DNA hypermethylation can promote ischemia reperfusion (I/R) injury by regulating the mitochondrial function. Diabetes mellitus (DM) is reported to induce DNA hypermethylation, but whether this prior DNA methylation in DM
Externí odkaz:
https://doaj.org/article/14164cdb47ff4e5f8fc6290e7ceded78
Autor:
Priyanka N. Prem, Gino A. Kurian
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Renal ischemia-reperfusion (IR) injury is one of the major causes of acute kidney injury influenced by the ischemic duration and the presence of comorbidities. Studies have reported that high-fat diet consumption can induce renal lipotoxicity and met
Externí odkaz:
https://doaj.org/article/eb34565694094e1ba4033c3992df160c