Výsledky vyhledávání - "Ginny L, Bumgardner"

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Antibody-suppressor CXCR5+CD8+ T cellular therapy ameliorates antibody-mediated rejection following kidney transplant in CCR5 KO mice

Autor: Jason M. Zimmerer, Jing L. Han, Chelsea M. Peterson, Qiang Zeng, Bryce A. Ringwald, Clarissa Cassol, Sachi Chaudhari, Madison Hart, Jessica Hemminger, Anjali Satoskar, Mahmoud Abdel-Rasoul, Jiao-Jing Wang, Robert T. Warren, Zheng J. Zhang, Christopher K. Breuer, Ginny L. Bumgardner

Publikováno v: Am J Transplant

CCR5 KO kidney transplant (KTx) recipients are extraordinarily high alloantibody producers and develop pathology that mimics human antibody-mediated rejection (AMR). C57BL/6 and CCR5 KO mice (H-2(b)) were transplanted with A/J kidneys (H-2(a)); selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ccc1ef7cde2c389259d59da8fac2a9
https://doi.org/10.1111/ajt.16988

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Invariant NKT Cells Promote the Development of Highly Cytotoxic Multipotent CXCR3+CCR4+CD8+ T Cells That Mediate Rapid Hepatocyte Allograft Rejection

Autor: Jing Han, Madison M Hart, Ginny L. Bumgardner, Robert T. Warren, Chelsea M Peterson, Bryce A Ringwald, Sachi R Chaudhari, Mahmoud Abdel-Rasoul, Jason M. Zimmerer

Publikováno v: J Immunol

Hepatocyte transplant represents a treatment for metabolic disorders but is limited by immunogenicity. Our prior work identified the critical role of CD8+ T cells, with or without CD4+ T cell help, in mediating hepatocyte rejection. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bd6691be0e085cab8786d555bd82bd
https://doi.org/10.4049/jimmunol.2100334

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Machine perfusion of kidney allografts affects early but not late graft function

Autor: Kenneth Washburn, Austin Schenk, April Logan, Ashraf El-Hinnawi, Navdeep Singh, Amer Rajab, Ginny L. Bumgardner, Guy Brock

Publikováno v: Am J Surg

Background Hypothermic machine perfusion (HMP) parameters are influenced by donor variables which further affect recipient outcome. Interplay between these parameters can help to predict kidney performance on pump and the long term outcome. Methods A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bbcb1d2e24d07fec2ef995dcdaed10
https://europepmc.org/articles/PMC9017432/

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CXCR5(+)CD8(+) T cells: A Review of their Antibody Regulatory Functions and Clinical Correlations

Autor: Steven M. Elzein, Jing L Han, Ginny L. Bumgardner, Jason M. Zimmerer, Bryce A Ringwald

Publikováno v: J Immunol

CD8+ T cells have conventionally been studied in relationship to pathogen or tumor clearance. Recent reports have identified novel functions of CXCR5+CD8+ T cells that can home to lymphoid follicles, a key site of Ab production. In this review, we pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb056a1d9b037c0ded74bc7f7cdd53b
https://europepmc.org/articles/PMC8486376/

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Alloprimed antibody-suppressor CD8+ T cells preferentially kill alloprimed germinal center B cells

Autor: Jason M Zimmerer, Sachi Chaudhari, Ginny L Bumgardner

Publikováno v: The Journal of Immunology. 208:53.06-53.06

Antibody-mediated rejection is a significant contributor to transplant rejection. Our prior work identified a novel subset of CXCR5+CD8+ T cells (CD8+ TAb-supp cells) that suppresses alloantibody production by mediating cytotoxic killing of IgG+ allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc38a9e8b500880aa236e026e2882b27
https://doi.org/10.4049/jimmunol.208.supp.53.06

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Deficiency of antibody-suppressor CXCR5+CD8+ T cells (not CD4+ Tregs) drives high alloantibody production in CCR5 KO kidney transplant recipients

Autor: Jing Light Han, Jason Zimmerer, Qiang Zeng, Sachi Chaudhari, Christopher Breuer, Ginny L Bumgardner

Publikováno v: The Journal of Immunology. 208:175.09-175.09

Kidney transplant (KTx) into CCR5 KO mice is an excellent model to study AMR immunobiology due to a heightened humoral response posited to be secondary to impaired CD4+Treg cell trafficking to the allograft. We have observed that adoptive cell therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::152e768af863c9d0452ea67e5e52a621
https://doi.org/10.4049/jimmunol.208.supp.175.09

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Synergistic effect of CXCR5+CD8+TAb-supp cell therapy and mTOR inhibition (but not calcineurin inhibition) in suppressing alloantibody following kidney transplant in mice

Autor: Jing Light Han, Jason Zimmerer, Qiang Zeng, Sachi Chaudhari, Christopher Breuer, Ginny L Bumgardner

Publikováno v: The Journal of Immunology. 208:175.16-175.16

CXCR5+CD8+TAb-supp cells inhibit alloantibody (alloAb) production, AMR, and prolong graft survival in mouse models. To determine if this cell therapy is compatible with standard immunosuppression (IS) strategies, we investigate the interaction of CD8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd6cf921983c84ef56e3333f4d75b667
https://doi.org/10.4049/jimmunol.208.supp.175.16

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Akademický článek

Inhibition of Recall Responses through Complementary Therapies Targeting CD8 T-Cell- and Alloantibody-Dependent Allocytotoxicity in Sensitized Transplant Recipients

Autor: Jason M. Zimmerer, Phillip H. Horne, Lori A. Fiessinger, Mason G. Fisher, Kartika Jayashankar, Sierra F. Garcia, Mahmoud Abdel-Rasoul, Nico Van Rooijen, Ginny L. Bumgardner M.D., Ph.D., F.A.C.S.

Publikováno v: Cell Transplantation, Vol 22 (2013)

Allospecific T memory cell responses in transplant recipients arise from environmental exposure to previous transplantation or cross-reactive heterologous immunity. Unfortunately, these memory responses pose a significant barrier to the survival of t

Externí odkaz: https://doaj.org/article/63c26d8282bd4c38afaa132f999d1348

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