Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Ginny, Devonshire"'
Autor:
Alvin Wei Tian Ng, Dylan Peter McClurg, Ben Wesley, Shahriar A. Zamani, Emily Black, Ahmad Miremadi, Olivier Giger, Rogier ten Hoopen, Ginny Devonshire, Aisling M. Redmond, Nicola Grehan, Sriganesh Jammula, Adrienn Blasko, Xiaodun Li, Samuel Aparicio, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Karol Nowicki-Osuch, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly und
Externí odkaz:
https://doaj.org/article/70172e9506b8433ca7874eabf4b5a777
Autor:
Alvin Wei Tian Ng, Dylan Peter McClurg, Ben Wesley, Shahriar A. Zamani, Emily Black, Ahmad Miremadi, Olivier Giger, Rogier ten Hoopen, Ginny Devonshire, Aisling M. Redmond, Nicola Grehan, Sriganesh Jammula, Adrienn Blasko, Xiaodun Li, Samuel Aparicio, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Karol Nowicki-Osuch, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e131446b35e94c42af2e34ae89cd9a66
Autor:
Sujath Abbas, Oriol Pich, Ginny Devonshire, Shahriar A. Zamani, Annalise Katz-Summercorn, Sarah Killcoyne, Calvin Cheah, Barbara Nutzinger, Nicola Grehan, Nuria Lopez-Bigas, OCCAMS Consortium, Rebecca C. Fitzgerald, Maria Secrier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract A variety of mutational processes drive cancer development, but their dynamics across the entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood. We explore the mutagenic processes shaping oesophageal adenocar
Externí odkaz:
https://doaj.org/article/80b7ae7055464931a7d92bf9f8491937
Autor:
Alvin Wei Tian Ng, Gianmarco Contino, Sarah Killcoyne, Ginny Devonshire, Ray Hsu, Sujath Abbas, Jing Su, Aisling M. Redmond, Jamie M. J. Weaver, Matthew D. Eldridge, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Paul A. W. Edwards, Rebecca C. Fitzgerald
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Genomic structural variants (SVs) in cancer are notoriously difficult to identify, despite the impact they have on cancer progression and treatment efficacy. This study applies state-of-the-art computational methods to catalogue SVs in 383 cases of o
Externí odkaz:
https://doaj.org/article/0336bd3704d7461197a30b2d9ac48316
Autor:
Alana L. Cutliffe, Sharon L. McKenna, Darshan S. Chandrashekar, Alvin Ng, Ginny Devonshire, Rebecca C. Fitzgerald, Tracey R. O'Donovan, John J. Mackrill
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 2, Iss 6, Pp 543-575 (2021)
Aim: To investigate alterations in transcription of genes, encoding Ca2+ toolkit proteins, in oesophageal adenocarcinoma (OAC) and to assess associations between gene expression, tumor grade, nodal-metastatic stage, and patient survival. Methods:
Externí odkaz:
https://doaj.org/article/58ef77f77a3f4c3e9c1a48f2097907b3
Autor:
Juliane Perner, Sujath Abbas, Karol Nowicki-Osuch, Ginny Devonshire, Matthew D. Eldridge, Simon Tavaré, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Sequencing tumour genomes can reveal information about the processes that drive the formation of cancer. Here, the authors describe a method that can detect these mutational signatures from small amounts of DNA and degraded samples.
Externí odkaz:
https://doaj.org/article/956e89249c06462089e01b56f371ccef
Autor:
Karol Nowicki-Osuch, Lizhe Zhuang, Tik Shing Cheung, Emily L. Black, Neus Masqué-Soler, Ginny Devonshire, Aisling M. Redmond, Adam Freeman, Massimilliano di Pietro, Nastazja Pilonis, Wladyslaw Januszewicz, Maria O'Donovan, Simon Tavaré, Jacqueline D. Shields, Rebecca C. Fitzgerald
Publikováno v:
Cancer Discovery. :OF1-OF18
Intestinal metaplasia in the esophagus (Barrett's esophagus IM, or BE-IM) and stomach (GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively. We hypothesize that BE-IM and GIM follow parallel developmental trajectorie
Autor:
Xiaodun Li, Hayley E. Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Núria Galeano-Dalmau, William J. Barendt, Laura Letchford, Genevieve M. Leyden, Emma K. Goffin, Andrew Barthorpe, Howard Lightfoot, Elisabeth Chen, James Gilbert, Ayesha Noorani, Ginny Devonshire, Lawrence Bower, Amber Grantham, Shona MacRae, Nicola Grehan, David C. Wedge, Rebecca C. Fitzgerald, Mathew J. Garnett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids recapitulate the transcriptomic, genetic, and morphological landscape of the
Externí odkaz:
https://doaj.org/article/aa2121583c394435847f94d0542851c4
Autor:
Rebecca C. Fitzgerald, Jacqueline D. Shields, Simon Tavaré, Maria O'Donovan, Wladyslaw Januszewicz, Nastazja Pilonis, Massimilliano di Pietro, Adam Freeman, Aisling M. Redmond, Ginny Devonshire, Neus Masqué-Soler, Emily L. Black, Tik Shing Cheung, Lizhe Zhuang, Karol Nowicki-Osuch
This table contains marker genes identified in the pairwise comparison of clusters identified in fibroblast population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faec736952c3cecb9a79a71d09694f6
https://doi.org/10.1158/2159-8290.22841344.v1
https://doi.org/10.1158/2159-8290.22841344.v1
Autor:
Rebecca C. Fitzgerald, Jacqueline D. Shields, Simon Tavaré, Maria O'Donovan, Wladyslaw Januszewicz, Nastazja Pilonis, Massimilliano di Pietro, Adam Freeman, Aisling M. Redmond, Ginny Devonshire, Neus Masqué-Soler, Emily L. Black, Tik Shing Cheung, Lizhe Zhuang, Karol Nowicki-Osuch
This file captions for supplementary tables and supplementary figures S1-S28 together with their legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230bd22ba8af63e8ac9440223e794147
https://doi.org/10.1158/2159-8290.22841371.v1
https://doi.org/10.1158/2159-8290.22841371.v1