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High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease.

Autor: Krumm CS; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Sanders Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065, USA., Landzberg RS; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Ramos-Espiritu L; Fisher Drug Discovery Resource Center, The Rockefeller University, New York, NY 10065, USA., Adura C; Fisher Drug Discovery Resource Center, The Rockefeller University, New York, NY 10065, USA., Liu X; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA., Acuna M; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Xie Y; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Xu X; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Division of Surgical Sciences, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Tillman MC; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA., Li Y; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA., Glickman JF; Fisher Drug Discovery Resource Center, The Rockefeller University, New York, NY 10065, USA., Ortlund EA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA., Ginn JD; Sanders Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065, USA., Cohen DE; Division of Gastroenterology & Hepatology, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: dcohen@bwh.harvard.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2023 Dec; Vol. 78, pp. 101832. Date of Electronic Publication: 2023 Oct 30.

Discovery of potent and selective PKC-theta inhibitors.

Autor: Cywin CL; Boehringer Ingelheim Pharmaceuticals, Inc., Department of Medicinal Chemistry, 900 Ridgebury Road, Ridgefield, CT 06877-0368, USA. ccywin@rdg.boehringer-ingelheim.com, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG, Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H, Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR Jr, Brown ML

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jan 01; Vol. 17 (1), pp. 225-30. Date of Electronic Publication: 2006 Oct 19.