Výsledky vyhledávání

Abstract LB255: Benchmarking NGS integration site analysis methods in support of long-term safety monitoring of gene therapy products

Autor: Jeffrey M. Otto, Yongjun Fan, Guanhui Bao, David Corney, Ben Niu, Qiu Yu, Baursha Khan, Laure Turner, Chris Mozdzierz, Haythem Latif, Ginger Zhou

Publikováno v: Cancer Research. 83:LB255-LB255

The FDA Guidance to Industry on Long Term Follow-Up (LTFU) After Administration of Human Gene Therapy Products states the importance of longitudinal testing of gene products introduced into human subjects. Depending on the delivery mechanism, the the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b68a05db81cea36f2cb5b2637b78aa2
https://doi.org/10.1158/1538-7445.am2023-lb255

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Abstract LB130: High-throughput RNA sequencing directly from cell lysates enables reproducible phenotypic profiling for assessing novel compounds and treatments in cancer research

Autor: Andrea O'Hara, Michael Stephens, Ilaria DeVito, Laure Turner, Christopher Mozdzierz, Haythem Latif, Ginger Zhou

Publikováno v: Cancer Research. 82:LB130-LB130

New oncology therapies are driven by multiple approaches, with a heavy emphasis on small-molecule therapeutics to target cancer cells and provide a therapeutic benefit to cancer patients. These small-molecule compounds can be used as a stand-alone tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c636a7151098891a319d7cb9d9872f5b
https://doi.org/10.1158/1538-7445.am2022-lb130

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Abstract LB034: Evaluation of a novel single-cell RNA sequencing methodology for use in clinical trial settings

Autor: David Corney, Yang Han, Yu Qiu, Yongjun Fan, Michael Stephens, Andrea O'Hara, Laure Turner, Christopher Mozdzierz, Haythem Latif, Ginger Zhou

Publikováno v: Cancer Research. 82:LB034-LB034

Bulk RNA sequencing (RNA-seq) is regularly employed for transcriptional profiling but provides only a snapshot of the average population. Particularly when studying disease, understanding differences in diverse cells is essential thus single-cell res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82d09fbfb2d0e0a29e623984d3265953
https://doi.org/10.1158/1538-7445.am2022-lb034

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Abstract 3637: Validation of a workflow to enable massively parallel transcriptome analysis in cryopreserved tissues

Autor: Christopher Mozdzierz, Riley Graham, Ginger Zhou, Haythem Latif, Yang Han, Yongjun Fan, David C. Corney, Yu Qiu

Publikováno v: Cancer Research. 80:3637-3637

Tumor development and growth is a complex process involving interplay between stromal and neoplastic cells. Importantly, neoplastic subclones within tumors often possess different functional properties and metastatic potential, which may be obscured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34fb33ef79e745966984dff0480141a4
https://doi.org/10.1158/1538-7445.am2020-3637

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Adventitious Virus Contamination Testing: Massively Parallel Sequencing in a Multimodal Solution for Biopharmaceutical Safety Testing

Autor: Wenying Huang, Ginger Zhou, Stephen Karakasidis, Yankai Jia, Michael Hantman, Jeffrey Shaman, Jack Yu

Publikováno v: BioProcessing Journal. 12:18-24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f66251061646f3ffd52ded54e6cdf61c
https://doi.org/10.12665/j122.shamanhantman

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Akademický článek

Adventitious Virus Contamination Testing: Massively Parallel Sequencing in a Multimodal Solution for Biopharmaceutical Safety Testing.

Autor: JACK X. YU¹, KARAKASIDIS, STEPHEN², GINGER ZHOU¹, WENYING HUANG¹, YANKAI JIA¹, HANTMAN, MICHAEL J.² Michael.Hantman@crl.com, SHAMAN, JEFFREY A.¹ Jeffrey.Shaman@genewiz.com

Publikováno v: BioProcessing Journal. Summer2013, Vol. 12 Issue 2, p18-24. 7p. 1 Color Photograph, 6 Charts.

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