Zobrazeno 1 - 10
of 801
pro vyhledávání: '"Ginger D"'
Autor:
Sarah R. Leist, Alexandra Schäfer, Ellen L. Risemberg, Timothy A. Bell, Pablo Hock, Mark R. Zweigart, Colton L. Linnertz, Darla R. Miller, Ginger D. Shaw, Fernando Pardo Manuel de Villena, Martin T. Ferris, William Valdar, Ralph S. Baric
Publikováno v:
Virus Research, Vol 346, Iss , Pp 199399- (2024)
Coronaviruses have caused three severe epidemics since the start of the 21st century: SARS, MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing likelihood of future coronavirus outbreaks motivates greater understanding of
Externí odkaz:
https://doaj.org/article/9074f31c58d94cd2b9333731d7209b3e
Autor:
Alexandra Schäfer, Lisa E. Gralinski, Sarah R. Leist, Brea K. Hampton, Michael A. Mooney, Kara L. Jensen, Rachel L. Graham, Sudhakar Agnihothram, Sophia Jeng, Steven Chamberlin, Timothy A. Bell, D. Trevor Scobey, Colton L. Linnertz, Laura A. VanBlargan, Larissa B. Thackray, Pablo Hock, Darla R. Miller, Ginger D. Shaw, Michael S. Diamond, Fernando Pardo Manuel de Villena, Shannon K. McWeeney, Mark T. Heise, Vineet D. Menachery, Martin T. Ferris, Ralph S. Baric
Publikováno v:
Virus Research, Vol 344, Iss , Pp 199357- (2024)
Coronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, Middle East Respiratory CoV (MERS-CoV) in 2012, and SARS-CoV-2 in 2019. Althou
Externí odkaz:
https://doaj.org/article/b0e04c6b05a3457095b5a1d8a67680f6
Autor:
Jessica B. Graham, Jessica L. Swarts, Sarah R. Leist, Alexandra Schäfer, Timothy A. Bell, Pablo Hock, Joe Farrington, Ginger D. Shaw, Martin T. Ferris, Fernando Pardo-Manuel de Villena, Ralph S. Baric, Jennifer M. Lund
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109103- (2024)
Summary: The response to infection is generally heterogeneous and diverse, with some individuals remaining asymptomatic while others present with severe disease or a diverse range of symptoms. Here, we address the role of host genetics on immune phen
Externí odkaz:
https://doaj.org/article/6feb8dbc17114d739ae8c4075c31ef37
Autor:
Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Joao A. Paulo, Steven P. Gygi, Gary A. Churchill
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-29 (2023)
Abstract Background Phosphorylation of proteins is a key step in the regulation of many cellular processes including activation of enzymes and signaling cascades. The abundance of a phosphorylated peptide (phosphopeptide) is determined by the abundan
Externí odkaz:
https://doaj.org/article/812d1f4d20a34130b1e4a7ae5bae7fb5
Autor:
Marta C. Cruz Cisneros, Elizabeth J. Anderson, Brea K. Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A. Bell, Matthew Blanchard, Jacob A. Dillard, Kenneth H. Dinnon, Pablo Hock, Sarah R. Leist, Emily A. Madden, Ginger D. Shaw, Ande West, Ralph S. Baric, Victoria K. Baxter, Fernando Pardo-Manuel de Villena, Mark T. Heise, Martin T. Ferris
Publikováno v:
Vaccines, Vol 12, Iss 1, p 103 (2024)
The COVID-19 pandemic led to the rapid and worldwide development of highly effective vaccines against SARS-CoV-2. However, there is significant individual-to-individual variation in vaccine efficacy due to factors including viral variants, host age,
Externí odkaz:
https://doaj.org/article/43d9495ddc00404dbe9f7ec34a4f0cf8
Autor:
Tanvi Arkatkar, Veronica Davé, Irene Cruz Talavera, Jessica B. Graham, Jessica L. Swarts, Sean M. Hughes, Timothy A. Bell, Pablo Hock, Joe Farrington, Ginger D. Shaw, Anna Kirby, Michael Fialkow, Meei-Li Huang, Keith R. Jerome, Martin T. Ferris, Florian Hladik, Joshua T. Schiffer, Martin Prlic, Jennifer M. Lund
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Mucosal infections pose a significant global health burden. Antigen-specific tissue-resident T cells are critical to maintaining barrier immunity. Previous studies in the context of systemic infection suggest that memory CD8+ T cells may also provide
Externí odkaz:
https://doaj.org/article/c1f6027d12e448b38a3cfc27c143ba2e
Autor:
Brea K Hampton, Kenneth S Plante, Alan C Whitmore, Colton L Linnertz, Emily A Madden, Kelsey E Noll, Samuel P Boyson, Breantie Parotti, James G Xenakis, Timothy A Bell, Pablo Hock, Ginger D Shaw, Fernando Pardo-Manuel de Villena, Martin T Ferris, Mark T Heise
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010548 (2022)
Variation in immune homeostasis, the state in which the immune system is maintained in the absence of stimulation, is highly variable across populations. This variation is attributed to both genetic and environmental factors. However, the identity an
Externí odkaz:
https://doaj.org/article/15976cb8c23a4cb6bff3f652de673521
Autor:
Alexandra Schäfer, Sarah R. Leist, Lisa E. Gralinski, David R. Martinez, Emma S. Winkler, Kenichi Okuda, Padraig E. Hawkins, Kendra L. Gully, Rachel L. Graham, D. Trevor Scobey, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Jennifer F. Loome, Emily A. Madden, Elizabeth Anderson, Victoria K. Baxter, Sharon A. Taft-Benz, Mark R. Zweigart, Samantha R. May, Stephanie Dong, Matthew Clark, Darla R. Miller, Rachel M. Lynch, Mark T. Heise, Roland Tisch, Richard C. Boucher, Fernando Pardo Manuel de Villena, Stephanie A. Montgomery, Michael S. Diamond, Martin T. Ferris, Ralph S. Baric
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Infectious diseases have shaped the human population genetic structure, and genetic variation influences the susceptibility to many viral diseases. However, a variety of challenges have made the implementation of traditional human Genome-wid
Externí odkaz:
https://doaj.org/article/0653e049732d4652b9b825ecba93c24d
Autor:
Christiann H. Gaines, Sarah A. Schoenrock, Joseph Farrington, David F. Lee, Lucas J. Aponte-Collazo, Ginger D. Shaw, Darla R. Miller, Martin T. Ferris, Fernando Pardo-Manuel de Villena, Lisa M. Tarantino
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societal burden, but there are currently no FDA-approved therapies. The development of novel and effective treatments has been hindered by substantial gaps
Externí odkaz:
https://doaj.org/article/4393c2d6495448268539404cd26c8693
Autor:
Paola Giusti-Rodríguez, James G. Xenakis, James J. Crowley, Randal J. Nonneman, Daniela M. DeCristo, Allison Ryan, Corey R. Quackenbush, Darla R. Miller, Ginger D. Shaw, Vasyl Zhabotynsky, Patrick F. Sullivan, Fernando Pardo Manuel de Villena, Fei Zou
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3165-3177 (2020)
Schizophrenia is an idiopathic disorder that affects approximately 1% of the human population, and presents with persistent delusions, hallucinations, and disorganized behaviors. Antipsychotics are the standard pharmacological treatment for schizophr
Externí odkaz:
https://doaj.org/article/5f8d499338a344dbb93bdab1443f738f