Výsledky vyhledávání - "Ginette Santiago‐Sanchez"

Akademický článek

Alum-anchored IL-12 combined with cytotoxic chemotherapy and immune checkpoint blockade enhanced antitumor immune responses in head and neck cancer models

Autor: James W Hodge, Howard Kaufman, Michelle R Padget, Kellsye P Fabian, Sailaja Battula, Wiem Lassoued, Ginette Santiago-Sanchez, Clint Tanner Allen

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)

Background First-line treatment with pembrolizumab plus chemotherapy in recurrent and metastatic head and neck squamous cell carcinomas (HNSCC) has improved survival. However, the overall response rate with this standard of care regimen (SOC) remains

Externí odkaz: https://doaj.org/article/80385c13cd354da09a43545dc65bb962

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Akademický článek

788 Improved immunologic and therapeutic activity of anchored interleukin (IL-12) immunotherapy in combination with cytotoxic chemotherapy and immune checkpoint inhibitor in a head and neck cancer model

Autor: Jeffrey Schlom, Leisha A Emens, Howard Kaufman, James Hodge, Sailaja Battula, Kellsye Fabian, Ginette Santiago-Sanchez

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/2f3bdd4b422f46a1b187d0fadbd145fe

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Akademický článek

Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion

Autor: Emilly S. Villodre, Xiaoding Hu, Richard Larson, Pascal Finetti, Kristen Gomez, Wintana Balema, Shane R. Stecklein, Ginette Santiago‐Sanchez, Savitri Krishnamurthy, Juhee Song, Xiaoping Su, Naoto T. Ueno, Debu Tripathy, Steven Van Laere, François Bertucci, Pablo Vivas‐Mejía, Wendy A. Woodward, Bisrat G. Debeb

Publikováno v: Molecular Oncology, Vol 15, Iss 10, Pp 2752-2765 (2021)

Inflammatory breast cancer (IBC) is an aggressive form of primary breast cancer characterized by rapid onset and high risk of metastasis and poor clinical outcomes. The biological basis for the aggressiveness of IBC is still not well understood and n

Externí odkaz: https://doaj.org/article/8e186a4924364ac4b8997f8fc8947ced

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Akademický článek

Immune targeting of three independent suppressive pathways (TIGIT, PD-L1, TGFβ) provides significant antitumor efficacy in immune checkpoint resistant models

Autor: S. Elizabeth Franks, Kellsye P. Fabian, Ginette Santiago-Sánchez, Benjamin Wolfson, James W. Hodge

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Immune checkpoint blockade (ICB) therapy, while groundbreaking, must be improved to promote enhanced durable responses and to prevent the development of treatment-refractory disease. Cancer therapies that engage, enable, and expand the antitumor immu

Externí odkaz: https://doaj.org/article/d1c205af3126416db25719406b38af02

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