Trigonelline is an NAD ⁺ precursor that improves muscle function during ageing and is reduced in human sarcopenia.

Autor: Membrez M; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland., Migliavacca E; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland., Christen S; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Lausanne, Switzerland., Yaku K; Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama, Japan., Trieu J; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Lee AK; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Morandini F; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Giner MP; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Lausanne, Switzerland., Stiner J; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Makarov MV; Mitchell Cancer Institute, Department of Pharmacology, F. P. Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA., Garratt ES; Institute of Developmental Sciences, Human Developmental and Health, Faculty of Medicine, University of Southampton, Southampton, UK.; National Institute for Health and Care Research, Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Vasiloglou MF; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland., Chanvillard L; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Dalbram E; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ehrlich AM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sanchez-Garcia JL; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland., Canto C; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Karagounis LG; Nestlé Health Science, Translation Research, Lausanne, Switzerland.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Treebak JT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Migaud ME; Mitchell Cancer Institute, Department of Pharmacology, F. P. Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA., Heshmat R; Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Razi F; Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Science Institute, Tehran University of Medical Sciences, Tehran, Iran., Karnani N; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ostovar A; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Farzadfar F; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Tay SKH; KTP-National University Children's Medical Institute, National University Hospital, Singapore, Singapore., Sanders MJ; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland., Lillycrop KA; Institute of Developmental Sciences, Human Developmental and Health, Faculty of Medicine, University of Southampton, Southampton, UK.; National Institute for Health and Care Research, Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK., Godfrey KM; Institute of Developmental Sciences, Human Developmental and Health, Faculty of Medicine, University of Southampton, Southampton, UK.; National Institute for Health and Care Research, Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Medical Research Council Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., Nakagawa T; Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama, Japan., Moco S; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Lausanne, Switzerland.; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Koopman R; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Lynch GS; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Sorrentino V; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland. vsorrent@nus.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. vsorrent@nus.edu.sg.; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. vsorrent@nus.edu.sg., Feige JN; Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland. Jerome.feige@rd.nestle.com.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Jerome.feige@rd.nestle.com.

Publikováno v: Nature metabolism [Nat Metab] 2024 Mar; Vol. 6 (3), pp. 433-447. Date of Electronic Publication: 2024 Mar 19.

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD ⁺ by Generating Dihydronicotinamide Riboside.

Autor: Ciarlo E; Nestlé Institute of Health Sciences, Nestlé Research Ltd., EPFL Innovation Park, 1015 Lausanne, Switzerland., Joffraud M; Nestlé Institute of Health Sciences, Nestlé Research Ltd., EPFL Innovation Park, 1015 Lausanne, Switzerland., Hayat F; Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36693, USA., Giner MP; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research Ltd., EPFL Innovation Park, 1015 Lausanne, Switzerland., Giroud-Gerbetant J; Nestlé Institute of Health Sciences, Nestlé Research Ltd., EPFL Innovation Park, 1015 Lausanne, Switzerland., Sanchez-Garcia JL; Nestlé Institute of Health Sciences, Nestlé Research Ltd., EPFL Innovation Park, 1015 Lausanne, Switzerland., Rumpler M; Nestlé Institute of Health Sciences, Nestlé Research Ltd., EPFL Innovation Park, 1015 Lausanne, Switzerland., Moco S; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research Ltd., EPFL Innovation Park, 1015 Lausanne, Switzerland.; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands., Migaud ME; Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36693, USA., Cantó C; Nestlé Institute of Health Sciences, Nestlé Research Ltd., EPFL Innovation Park, 1015 Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

Publikováno v: Nutrients [Nutrients] 2022 Jul 01; Vol. 14 (13). Date of Electronic Publication: 2022 Jul 01.

Biomarker-based validity of a food frequency questionnaire estimating intake in Brazilian children and adolescents.

Autor: Hillesheim E; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Toffano RBD; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Barros TT; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Salomão RG; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Mathias MG; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Coelho-Landell CA; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Almada MORDV; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Camarneiro JM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Camelo-Junior JS; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Ued FDV; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Campos-Gimenez E; Nestlé Research Center, Lausanne, Switzerland., Redeuil K; Nestlé Research Center, Lausanne, Switzerland., Giner MP; Nestlé Institute of Health Sciences, Lausanne, Switzerland., Martin FP; Nestlé Institute of Health Sciences, Lausanne, Switzerland., Montoliu I; Nestlé Institute of Health Sciences, Lausanne, Switzerland., Moco S; Nestlé Institute of Health Sciences, Lausanne, Switzerland., Kaput J; Nestlé Institute of Health Sciences, Lausanne, Switzerland., Monteiro JP; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Publikováno v: International journal of food sciences and nutrition [Int J Food Sci Nutr] 2021 Mar; Vol. 72 (2), pp. 236-247. Date of Electronic Publication: 2020 Jul 07.

Mitochondrial oxidative capacity and NAD ⁺ biosynthesis are reduced in human sarcopenia across ethnicities.

Autor: Migliavacca E; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Tay SKH; KTP-National University Children's Medical Institute, National University Hospital, Singapore, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Patel HP; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Academic Geriatric Medicine, , University of Southampton, Southampton, UK., Sonntag T; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland.; EPFL school of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland., Civiletto G; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., McFarlane C; Department of Molecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, Queensland, Australia., Forrester T; UWI Solutions for Developing Countries, UWI SODECO, University of West Indies, Kingston, Jamaica., Barton SJ; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Leow MK; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.; Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Antoun E; Institute of Developmental Sciences, University of Southampton, Southampton, UK.; Centre for Biological Sciences, University of Southampton, Southampton, UK., Charpagne A; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Seng Chong Y; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Descombes P; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Feng L; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Francis-Emmanuel P; UWI Solutions for Developing Countries, UWI SODECO, University of West Indies, Kingston, Jamaica., Garratt ES; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Institute of Developmental Sciences, University of Southampton, Southampton, UK., Giner MP; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Green CO; UWI Solutions for Developing Countries, UWI SODECO, University of West Indies, Kingston, Jamaica., Karaz S; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Kothandaraman N; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore., Marquis J; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Metairon S; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Moco S; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Nelson G; UWI Solutions for Developing Countries, UWI SODECO, University of West Indies, Kingston, Jamaica., Ngo S; Liggins Institute, University of Auckland, Auckland, New Zealand., Pleasants T; Liggins Institute, University of Auckland, Auckland, New Zealand., Raymond F; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland., Sayer AA; Academic Geriatric Medicine, , University of Southampton, Southampton, UK.; AGE Research Group, Institute of Neuroscience, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.; NIHR Newcastle Biomedical Research Centre, Newcastle upon-Tyne NHS Foundation Trust and Newcastle University, Newcastle, UK., Ming Sim C; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore., Slater-Jefferies J; Institute of Developmental Sciences, University of Southampton, Southampton, UK., Syddall HE; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Fang Tan P; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore., Titcombe P; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Vaz C; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore., Westbury LD; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Wong G; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore., Yonghui W; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore., Cooper C; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.; National Institute for Health Research Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK., Sheppard A; Liggins Institute, University of Auckland, Auckland, New Zealand., Godfrey KM; Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. kmg@mrc.soton.ac.uk.; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. kmg@mrc.soton.ac.uk.; Institute of Developmental Sciences, University of Southampton, Southampton, UK. kmg@mrc.soton.ac.uk., Lillycrop KA; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. K.A.Lillycrop@soton.ac.uk.; Institute of Developmental Sciences, University of Southampton, Southampton, UK. K.A.Lillycrop@soton.ac.uk.; Centre for Biological Sciences, University of Southampton, Southampton, UK. K.A.Lillycrop@soton.ac.uk., Karnani N; Singapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore. neerja_karnani@sics.a-star.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. neerja_karnani@sics.a-star.edu.sg., Feige JN; Nestle Research, EPFL Innovation Park, Lausanne, Switzerland. Jerome.feige@rd.nestle.com.; EPFL school of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. Jerome.feige@rd.nestle.com.

Publikováno v: Nature communications [Nat Commun] 2019 Dec 20; Vol. 10 (1), pp. 5808. Date of Electronic Publication: 2019 Dec 20.

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage.

Autor: Sambeat A; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Ratajczak J; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Joffraud M; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Sanchez-Garcia JL; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Giner MP; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Valsesia A; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Giroud-Gerbetant J; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Valera-Alberni M; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Cercillieux A; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Boutant M; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Kulkarni SS; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Moco S; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland., Canto C; Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland. carlos.cantoalvarez@rd.nestle.com.; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland. carlos.cantoalvarez@rd.nestle.com.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 20; Vol. 10 (1), pp. 4291. Date of Electronic Publication: 2019 Sep 20.