Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gina de Boer"'
Autor:
JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield
Publikováno v:
eLife, Vol 11 (2022)
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://doaj.org/article/ff1c4ccf767e411f85c1b12a0db8fe55
Autor:
Sultan Chowdhury, David Bogucki, Rostam Namdari, Girish Bankar, Wei Zhang, James Roy Empfield, Matthew Waldbrook, Stephanie M Lee, Lofstrand Verner Alexander, Karen Nelkenbrecher, Samuel J. Goodchild, Rhena Yoo, Noah G. Shuart, Wesolowski Steven Sigmund, Elaine Chang, Mandy Feng, Clint Young, Christoph Martin Dehnhardt, Jenny Li, Zhiwei Xie, Michael Edward Grimwood, Abid Hasan, Sophia Lin, Kristen Burford, Raymond J. Winquist, Charles J. Cohen, Alla Yurevna Zenova, Simon N. Pimstone, Michael R. Wilson, Parisa Karimi Tari, Kuldip Khakh, Celine Dube, Aaron M. Williams, Robin Sherrington, Luis Sojo, Andrea Lindgren, J. P. Johnson, Thilo Focken, Qi Jia, Jean-Christophe Andrez, Shannon Decker, Matthew Taron, Diana Weeratunge, Richard T. Dean, Janette Mezeyova, Shaoyi Sun, Wei Gong, Angela Hussainkhel, Gina de Boer, Alison Jane Cutts
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e2e6674136369f3abcd5070b52e762
https://doi.org/10.1101/2021.08.29.458125
https://doi.org/10.1101/2021.08.29.458125
Autor:
J P, Johnson, Thilo, Focken, Kuldip, Khakh, Parisa Karimi, Tari, Celine, Dube, Samuel J, Goodchild, Jean-Christophe, Andrez, Girish, Bankar, David, Bogucki, Kristen, Burford, Elaine, Chang, Sultan, Chowdhury, Richard, Dean, Gina, de Boer, Shannon, Decker, Christoph, Dehnhardt, Mandy, Feng, Wei, Gong, Michael, Grimwood, Abid, Hasan, Angela, Hussainkhel, Qi, Jia, Stephanie, Lee, Jenny, Li, Sophia, Lin, Andrea, Lindgren, Verner, Lofstrand, Janette, Mezeyova, Rostam, Namdari, Karen, Nelkenbrecher, Noah Gregory, Shuart, Luis, Sojo, Shaoyi, Sun, Matthew, Taron, Matthew, Waldbrook, Diana, Weeratunge, Steven, Wesolowski, Aaron, Williams, Michael, Wilson, Zhiwei, Xie, Rhena, Yoo, Clint, Young, Alla, Zenova, Wei, Zhang, Alison J, Cutts, Robin P, Sherrington, Simon N, Pimstone, Raymond, Winquist, Charles J, Cohen, James R, Empfield
Publikováno v:
eLife. 11
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3cf389ce4c308fb570995099c2f50504
https://pubmed.ncbi.nlm.nih.gov/35234610
https://pubmed.ncbi.nlm.nih.gov/35234610
Autor:
Parisa Karimi Tari, Charles J. Cohen, Matthew Waldbrook, Christoph Martin Dehnhardt, Clint Young, Maegan Soriano, Rainbow Kwan, Matt Taron, Kristen Burford, Sultan Chowdhury, Noah G. Shuart, Lofstrand Verner Alexander, Michael D. Wilson, Karen Nelkenbrecher, Jean-Christophe Andrez, Michael Edward Grimwood, Wei Gong, Robert J. DeVita, J. P. Johnson, James Roy Empfield, Alla Yurevna Zenova, Luis Sojo, Andrea Lindgren, Thilo Focken, Shannon Decker, Gina de Boer, Samuel J. Goodchild, Wesolowski Steven Sigmund, Sophia Lin, Stephanie Lee
Publikováno v:
Journal of Medicinal Chemistry. 62:9618-9641
Nonselective antagonists of voltage-gated sodium (NaV) channels have been long used for the treatment of epilepsies. The efficacy of these drugs is thought to be due to the block of sodium channels on excitatory neurons, primarily NaV1.6 and NaV1.2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25eea9fc94c4d0a50d32b1585395b3e1
https://doi.org/10.1021/acs.jmedchem.9b01032
https://doi.org/10.1021/acs.jmedchem.9b01032
Autor:
Shaoyi, Sun, Qi, Jia, Alla Y, Zenova, Sophia, Lin, Angela, Hussainkhel, Janette, Mezeyova, Elaine, Chang, Samuel J, Goodchild, Zhiwei, Xie, Andrea, Lindgren, Gina, de Boer, Rainbow, Kwan, Kuldip, Khakh, Luis, Sojo, Paul, Bichler, J P, Johnson, James R, Empfield, Charles J, Cohen, Christoph M, Dehnhardt, Richard, Dean
Publikováno v:
Bioorganicmedicinal chemistry letters. 45
We describe the synthesis and biological evaluation of a series of novel aryl sulfonamides that exhibit potent inhibition of Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72ffd93fb821803255bea0175c7110a5
https://pubmed.ncbi.nlm.nih.gov/34044121
https://pubmed.ncbi.nlm.nih.gov/34044121
Autor:
Thilo, Focken, Kristen, Burford, Michael E, Grimwood, Alla, Zenova, Jean-Christophe, Andrez, Wei, Gong, Michael, Wilson, Matt, Taron, Shannon, Decker, Verner, Lofstrand, Sultan, Chowdhury, Noah, Shuart, Sophia, Lin, Samuel J, Goodchild, Clint, Young, Maegan, Soriano, Parisa K, Tari, Matthew, Waldbrook, Karen, Nelkenbrecher, Rainbow, Kwan, Andrea, Lindgren, Gina, de Boer, Stephanie, Lee, Luis, Sojo, Robert J, DeVita, Charles J, Cohen, Steven S, Wesolowski, J P, Johnson, Christoph M, Dehnhardt, James R, Empfield
Publikováno v:
Journal of medicinal chemistry. 62(21)
Nonselective antagonists of voltage-gated sodium (Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83cdc1c0cbb195dcbc6825acef82c33c
https://pubmed.ncbi.nlm.nih.gov/31525968
https://pubmed.ncbi.nlm.nih.gov/31525968