Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Gina Ney"'
Autor:
Xi Jin, Victor Ng, Meiling Zhao, Lu Liu, Tomoyasu Higashimoto, Zheng Hong Lee, Jooho Chung, Victor Chen, Gina Ney, Malathi Kandarpa, Moshe Talpaz, Qing Li
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 5 (2022)
RAS mutations occur in a broad spectrum of human hematopoietic malignancies. Activating Ras mutations in blood cells leads to hematopoietic malignancies in mice. In murine hematopoietic stem cells (HSCs), mutant N-RasG12D activates Stat5 to dysregula
Externí odkaz:
https://doaj.org/article/59507399254546bcbfb824add9ce3b5b
Autor:
Xi Jin, Tingting Qin, Meiling Zhao, Nathanael Bailey, Lu Liu, Kevin Yang, Victor Ng, Tomoyasu Higashimoto, Rosemary Coolon, Gina Ney, Maria E. Figueroa, Qing Li
Publikováno v:
Blood Advances, Vol 2, Iss 11, Pp 1259-1271 (2018)
Abstract: Concurrent genetic lesions exist in a majority of patients with hematologic malignancies. Among these, somatic mutations that activate RAS oncogenes and inactivate the epigenetic modifier ten-eleven translocation 2 (TET2) frequently co-occu
Externí odkaz:
https://doaj.org/article/b0b4a6dab15f4ea8ab414d91438885c8
Publikováno v:
American journal of medical genetics. Part C, Seminars in medical geneticsREFERENCES. 190(4)
RASopathies are a set of clinical syndromes that have molecular and clinical overlap. Genetically, these syndromes are defined by germline pathogenic variants in RAS/MAPK pathway genes resulting in activation of this pathway. Clinically, their common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c9658e727d871f5d0c0ff45a67b239
https://pubmed.ncbi.nlm.nih.gov/36533693
https://pubmed.ncbi.nlm.nih.gov/36533693
Autor:
Wun Kuk, Meiling Zhao, Qing Li, Laura M. McKay, Victor Ng, Morgan Jones, Xi Jin, Gina Ney, Lila Alaka, Kevin B Yang, Lu Liu, Adam Ross, Leilani Sampang, Hadie Evarts
Publikováno v:
Cancer Res
Leukemic relapse is believed to be driven by transformed hematopoietic stem cells (HSC) that harbor oncogenic mutations or have lost tumor suppressor function. Recent comprehensive sequencing studies have shown that mutations predicted to activate Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9594d048442b5865c79de91bdb99fe73
https://doi.org/10.1158/0008-5472.can-20-0118
https://doi.org/10.1158/0008-5472.can-20-0118
Autor:
Xi Jin, Victor Ng, Meiling Zhao, Lu Liu, Tomoyasu Higashimoto, Zheng Hong Lee, Jooho Chung, Victor Chen, Gina Ney, Malathi Kandarpa, Moshe Talpaz, Qing Li
Publikováno v:
Disease modelsmechanisms. 15(5)
RAS mutations occur in a broad spectrum of human hematopoietic malignancies. Activating Ras mutations in blood cells leads to hematopoietic malignancies in mice. In murine hematopoietic stem cells (HSCs), mutant N-RasG12D activates Stat5 to dysregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ca12ae1649501f3ee4f283339a23bf
https://pubmed.ncbi.nlm.nih.gov/35352806
https://pubmed.ncbi.nlm.nih.gov/35352806
Publikováno v:
Cancer Res
As genomic sequencing has become more widely available, the high prevalence of Ras pathway mutations in pediatric diseases has begun to emerge. Germline Ras-activating mutations have been known to contribute to cancer predisposition in a group of dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775de0f851a1cb82d1a5d21cb4f99f31
https://europepmc.org/articles/PMC10081825/
https://europepmc.org/articles/PMC10081825/
Autor:
Gina Ney, Meiling Zhao, Xi Jin, Morgan Jones, Fengbiao Mao, Lu Liu, Ling Qi, Shengyi Sun, Qing Li, Guojun Shi, Ken Inoki, Ayaka Inoki, Kelly Fan, Yali Dou
Publikováno v:
Blood. 136(26)
Hematopoietic stem cells (HSC) self-renew to sustain stem cell pools and differentiate to generate all types of blood cells. HSCs remain in quiescence to sustain their long-term self-renewal potential. It remains unclear whether protein quality contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378911f7c98afcdb952379743f1482db
https://pubmed.ncbi.nlm.nih.gov/33367552
https://pubmed.ncbi.nlm.nih.gov/33367552
Autor:
Pankaj Vats, Rajen Mody, Dan R. Robinson, Jonathan Bender, Bailey Anderson, Chandan Kumar-Sinha, Qing Li, Yi-Mi Wu, Marcin Cieslik, Gina Ney, Arul M. Chinnaiyan
Background Cancer remains the number one cause of disease-related mortality in children, and despite advances in the molecular understanding of leukemia and targeted therapies, refractory leukemia remains a leading cause of death. It therefore is ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0667ec3a054ed0e4cdd3a930c95a7a63
https://europepmc.org/articles/PMC7036640/
https://europepmc.org/articles/PMC7036640/
Autor:
Tomoyasu Higashimoto, Nathanael G. Bailey, Victor Ng, Gina Ney, Lu Liu, Rosemary Coolon, Tingting Qin, Meiling Zhao, Kevin B Yang, Maria E. Figueroa, Qing Li, Xi Jin
Publikováno v:
Blood Advances. 2:1259-1271
Concurrent genetic lesions exist in a majority of patients with hematologic malignancies. Among these, somatic mutations that activate RAS oncogenes and inactivate the epigenetic modifier ten-eleven translocation 2 (TET2) frequently co-occur in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5f3f66a614cdc2d6665978de82d33f
https://doi.org/10.1182/bloodadvances.2018017400
https://doi.org/10.1182/bloodadvances.2018017400
Autor:
Ling Qi, Ken Inoki, Shengyi Sun, Fengbiao Mao, Guojun Shi, Ayaka Inoki, Kelly Fan, Yali Dou, Xi Jin, Meiling Zhao, Gina Ney, Lu Liu, Qing Li
SummaryMany tissue-specific stem cells require quiescence to sustain stem cell pool and maintain lifelong tissue integrity. It remains unclear whether protein quality control is required for stem cells in quiescence when RNA content, protein synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05a1b209af0bad9aefe53803fa4b504