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pro vyhledávání: '"Gina N. Wharton"'
Autor:
Gina N. Wharton, Cristina Cozzo Picca, Jan Erikson, Michele H. Metzgar, Michele L. Fields, Brian D. Hondowicz, Simone A. Nish, Andrew J. Caton
Publikováno v:
The Journal of Immunology. 175:4255-4264
To investigate the mechanism by which T regulatory (Treg) cells may control the early onset of autoimmunity, we have used an adoptive transfer model to track Treg, Th, and anti-chromatin B cell interactions in vivo. We show that anti-chromatin B cell
Autor:
Jan Erikson, Michele L. Fields, Simone A. Nish, Brian D. Hondowicz, Michele H. Metzgar, Andrew J. Caton, Gina N. Wharton
Publikováno v:
The Journal of Immunology. 175:104-111
Circulating autoantibodies against dsDNA and chromatin are a characteristic of systemic lupus erythematosus in humans and many mouse models of this disease. B cells expressing these autoantibodies are normally regulated in nonautoimmune-prone mice bu
Autor:
Andrew J. Caton, Jan Erikson, Michele H. Metzgar, Brigette S. Adair, Brian D. Hondowicz, Shawn T. Alexander, Michele L. Fields, Gina N. Wharton
Publikováno v:
Immunological Reviews. 204:165-183
Anti-double-stranded DNA (anti-dsDNA) B cells are regulated in non-autoimmune mice. While some are deleted or undergo receptor editing, a population of anti-dsDNA (VH3H9/V lambda 1) B cells that emigrate into the periphery has also been identified. T