Výsledky vyhledávání - "Gina McMullen"

Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus-Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection and Evaluation of Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses

Autor: Kelong Han, Dickens Theodore, Gina McMullen, Eric Swayze, Michael McCaleb, Gaetan Billioud, Stefan Wieland, Steve Hood, Melanie Paff, C. Frank Bennett, T. Jesse Kwoh

Publikováno v: Clinical pharmacology in drug development. 11(10)

Dose-dependent reductions in hepatitis B virus (HBV) RNA, DNA, and viral proteins following bepirovirsen administration were observed in HepG2.2.15 cells. In HBV-transgenic mice treated at 50 mg/kg/wk, hepatic HBV RNA and DNA were reduced by 90% and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155eda77f8593f5516d4ef2cd8e9c822
https://pubmed.ncbi.nlm.nih.gov/35971951

Zobrazit plný text záznamu

Interspecies Scaling of Human Clearance and Plasma Trough Exposure for Antisense Oligonucleotides: A Retrospective Analysis of GalNAc3-Conjugated and Unconjugated-Antisense Oligonucleotides

Autor: Gina McMullen, Charvi Nanavati, Rosie Z. Yu, Yanfeng Wang, Scott P. Henry, Richard S. Geary

Publikováno v: Nucleic acid therapeutics. 31(4)

It is well documented and generally accepted that human clearance (CL) of unconjugated single-strand antisense oligonucleotides (ASOs) can be directly predicted from monkeys by body weight (BW) on a mg/kg dose basis. However, the scaling for trianten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358d598c863e745127456ab0533c214d
https://pubmed.ncbi.nlm.nih.gov/33891483

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání