Výsledky vyhledávání - "Gina M. Lenzi"

CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels

Autor: Vera Rocha-Perugini, Gina M. Lenzi, Henar Suárez, Baek Kim, Susana Álvarez, Francisco Sánchez-Madrid, Shoshana Levy, María Ángeles Muñoz-Fernández, Felipe Vences-Catalán, María Yáñez-Mó, Soraya López-Martín

Publikováno v: Nature microbiology
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

In this study, we report that the tetraspanin CD81 enhances human immunodeficiency virus (HIV)-1 reverse transcription in HIV-1-infected cells. This is enabled by the direct interaction of CD81 with the deoxynucleoside triphosphate phosphohydrolase S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de9637f85087ce057c625b680d25a05
http://europepmc.org/articles/PMC5660623

Zobrazit plný text záznamu

A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans

Autor: Alberto Brandariz-Nuñez, Baek Kim, Dmitri N. Ivanov, Gina M. Lenzi, Tommy E. White, Caitlin N. Knowlton, Alicia Martinez-Lopez, Felipe Diaz-Griffero

Publikováno v: Human Mutation. 38:658-668

Mutations in the human SAMHD1 gene are known to correlate with the development of the Aicardi-Goutieres Syndrome (AGS), which is an inflammatory encephalopathy that exhibits neurological dysfunction characterized by increased production of type I int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72670b09e3c3e96e240363b0c03d7a23
https://doi.org/10.1002/humu.23201

Zobrazit plný text záznamu

A G1‐like state allows HIV ‐1 to bypass SAMHD 1 restriction in macrophages

Autor: Petra Mlcochova, Katherine A. Sutherland, Alexandra Chittka, Christiana Georgiou, Gina M. Lenzi, Mahdad Noursadeghi, Stuart J. D. Neil, Sarah A. Watters, Robertus A. M. de Bruin, Asim Khwaja, Simon Yona, Baek Kim, Cosetta Bertoli, Jan Rehwinkel, Greg J. Towers, Matthew C. Gage, Ravindra K. Gupta

Publikováno v: Mlcochova, P, Sutherland, K A, Watters, S A, Bertoli, C, de Bruin, R A M, Rehwinkel, J, Neil, S J, Lenzi, G M, Kim, B, Khwaja, A, Gage, M C, Georgiou, C, Chittka, A, Yona, S, Noursadeghi, M, Towers, G J & Gupta, R K 2017, ' A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages ', The EMBO journal, vol. 36, no. 5, pp. 604-616 . https://doi.org/10.15252/embj.201696025
The EMBO Journal

An unresolved question is how HIV‐1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle‐associated proteins including MCM2 and cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b827e597ca2e337f38562406fc199183
https://doi.org/10.15252/embj.201696025

Zobrazit plný text záznamu

p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity

Autor: Michaela Müller-Trutwin, Françoise Barré-Sinoussi, Gianfranco Pancino, Gina M. Lenzi, Awatef Allouch, Annie David, Jose Carlos Valle-Casuso, Asier Sáez-Cirión, Baek Kim, Lydia R. Studdard

HIV-1 infection of noncycling cells, such as dendritic cells (DCs), is impaired due to limited availability of deoxynucleoside triphosphates (dNTPs), which are needed for HIV-1 reverse transcription. The levels of dNTPs are tightly regulated during t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4bf4fe1e00dffa15dc2e31d446678e
https://europepmc.org/articles/PMC5686764/

Zobrazit plný text záznamu

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells

Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 114, 2729-2734 (2017)

Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efb2b3ecca967b9c2d699c098055982
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53009

Zobrazit plný text záznamu

HPV31 utilizes the ATR-Chk1 pathway to maintain elevated RRM2 levels and a replication-competent environment in differentiating Keratinocytes

Autor: Daniel C. Anacker, Caitlin Shepard, Cary A. Moody, Bryan A. Johnson, Heather L. Aloor, Baek Kim, Gina M. Lenzi

Publikováno v: Virology. 499

Productive replication of human papillomaviruses (HPV) is restricted to the uppermost layers of the differentiating epithelia. How HPV ensures an adequate supply of cellular substrates for viral DNA synthesis in a differentiating environment is uncle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f58d588ff40e6f22be1ecff72e9c42
https://pubmed.ncbi.nlm.nih.gov/27764728

Zobrazit plný text záznamu

Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro

Autor: Erik Serrao, Simon C. Watkins, Gina M. Lenzi, Jennifer M. Zerbato, Zandrea Ambrose, Nicolas Sluis-Cremer, Alan Engelman, Baek Kim

Publikováno v: Journal of virology. 90(18)

The latent HIV-1 reservoir primarily resides in resting CD4 + T cells which are a heterogeneous population composed of both naive (T N ) and memory cells. In HIV-1-infected individuals, viral DNA has been detected in both naive and memory CD4 + T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232d43fda9e2f269e5700e993e3efc15
https://pubmed.ncbi.nlm.nih.gov/27356901

Zobrazit plný text záznamu

Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses

Autor: Gina M. Lenzi, Robert A. Domaoal, Raymond F. Schinazi, Baek Kim, Dong-Hyun Kim

Publikováno v: The Journal of Biological Chemistry

Among lentiviruses, HIV Type 2 (HIV-2) and many simian immunodeficiency virus (SIV) strains replicate rapidly in non-dividing macrophages, whereas HIV Type 1 (HIV-1) replication in this cell type is kinetically delayed. The efficient replication capa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7020bac27b844ca04b5ac2a649951292
https://pubmed.ncbi.nlm.nih.gov/26483545

Zobrazit plný text záznamu

Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses

Autor: Raymond F. Schinazi, Dong-Hyun Kim, Baek Kim, Robert A. Domaoal, Gina M. Lenzi

Publikováno v: Retrovirology

Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabeac2649ac15ee589c41faa0a72619
https://pubmed.ncbi.nlm.nih.gov/25524560

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání