Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Gina M. Leinninger"'
Autor:
Matthew Dawson, Dylan J. Terstege, Naila Jamani, Mio Tsutsui, Dmitrii Pavlov, Raluca Bugescu, Jonathan R. Epp, Gina M. Leinninger, Derya Sargin
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112815- (2023)
Summary: The hypothalamus plays a crucial role in the modulation of social behavior by encoding internal states. The hypothalamic hypocretin/orexin neurons, initially identified as regulators of sleep and appetite, are important for emotional and mot
Externí odkaz:
https://doaj.org/article/6fadc7d52d1d41f69924b239b82760bb
Autor:
Patricia Perez-Bonilla, Jariel Ramirez-Virella, Pooja Menon, Eva Troyano-Rodriguez, Sydney K. Arriaga, Anna Makela, Raluca Bugescu, Michael J. Beckstead, Gina M. Leinninger
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Central neurotensin signaling via neurotensin receptor-1 (NtsR1) modulates various aspects of physiology, including suppressing feeding and promoting locomotor activity that can support weight loss. However, it remains unclear when and where NtsR1 ex
Externí odkaz:
https://doaj.org/article/656cb02fd6c94327b9120073c7af0795
Autor:
Hillary L. Woodworth, Bethany G. Beekly, Hannah M. Batchelor, Raluca Bugescu, Patricia Perez-Bonilla, Laura E. Schroeder, Gina M. Leinninger
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3116-3128 (2017)
The central mechanism by which neurotensin (Nts) potentiates weight loss has remained elusive. We leveraged chemogenetics to reveal that Nts-expressing neurons of the lateral hypothalamic area (LHA) promote weight loss in mice by increasing volitiona
Externí odkaz:
https://doaj.org/article/5909b73fc5a141f3828127bbc27795ea
Autor:
Hillary L. Woodworth, Hannah M. Batchelor, Bethany G. Beekly, Raluca Bugescu, Juliette A. Brown, Gizem Kurt, Patrick M. Fuller, Gina M. Leinninger
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1881-1892 (2017)
Dopamine (DA) neurons in the ventral tegmental area (VTA) are heterogeneous and differentially regulate ingestive and locomotor behaviors that affect energy balance. Identification of which VTA DA neurons mediate behaviors that limit weight gain has
Externí odkaz:
https://doaj.org/article/f5165ac1fa0c4f1dbf4e6d236bed38da
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 1, Pp 11-22 (2006)
Dorsal root ganglia (DRG) neurons degenerate in diabetic neuropathy (DN) and exhibit mitochondrial damage. We studied mitochondria of cultured DRG neurons exposed to high glucose as an in vitro model of DN. High glucose sequentially increases the exp
Externí odkaz:
https://doaj.org/article/b054a9e5188a4744972c5ce98ab248b6
Autor:
Matthew Dawson, Dylan J Terstege, Naila Jamani, Dmitrii Pavlov, Mio Tsutsui, Raluca Bugescu, Jonathan R Epp, Gina M Leinninger, Derya Sargin
Intraspecies social interactions are integral for survival and maintenance of society among all mammalian species. Yet, our understanding of the neural systems and mechanisms involved in the establishment of social connectedness are limited. Since th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3af69b7e5ce97752381444eb382c043b
https://doi.org/10.1101/2022.08.19.504565
https://doi.org/10.1101/2022.08.19.504565
Autor:
Firozeh Farahmand, Michael Sidikpramana, Bara Yousef, Sarah Sharif, Kieana Shao, Qijun Tang, Gina M. Leinninger, Ali D. Güler, Andrew D. Steele
The introduction of processed foods high in fat and sugars has caused a dramatic increase in obesity in humans. Diet-induced obesity (DIO) can be modeled in laboratory mice by increasing the fat content of their diet. Previously, it was determined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbc7f3ed3d9514fbb7f550ea99221edf
https://doi.org/10.1101/2022.06.27.497778
https://doi.org/10.1101/2022.06.27.497778
Autor:
Alfred J. Robison, Andrew L. Eagle, Cynthia L. Jordan, Elizabeth S. Williams, Claire E. Manning, Ashlyn Swift-Gallant, Natalia Duque-Wilckens, Sadhana Chinnusamy, Adam J. Moeser, Gina M. Leinninger
Publikováno v:
Biol Psychiatry
Background Depression affects women nearly twice as often as men, but the neurobiological underpinnings of this discrepancy are unclear. Preclinical studies in male mice suggest that activity of ventral hippocampus (vHPC) neurons projecting to the nu
Autor:
Valentina Tremaroli, Anette Bjerregaard, Gina M. Leinninger, Fredrik Bäckhed, Birgitte Holst, Bolette Hartmann, Cecilia Ratner, Chinmay Kumar Dwibedi, Randy J. Seeley, Jae Hoon Shin
Publikováno v:
Endocrinology
Neurotensin (NT) is an anorexic gut hormone and neuropeptide that increases in circulation following bariatric surgery in humans and rodents. We sought to determine the contribution of NT to the metabolic efficacy of vertical sleeve gastrectomy (VSG)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c83c5fe0f40f4f2fc6aeb7a9a97da2a
https://europepmc.org/articles/PMC8294690/
https://europepmc.org/articles/PMC8294690/
Autor:
Gina M. Leinninger, Yeka Aponte, Miguel A. Arenivar, Justin N. Siemian, Cara B. Borja, Lydia J Erbaugh, Andrew L. Eagle, Alfred J. Robison, Sarah Sarsfield
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Understanding how neuronal circuits control nociceptive processing will advance the search for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic parvalbumin-positive (LHPV) glutamatergic neurons respond to acute the