Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gina M. Capiaux"'
Autor:
Frank Maley, Philipp Mayer-Kuckuk, Joseph R. Bertino, Gina M. Capiaux, Tulin Budak-Alpdogan, Debabrata Banerjee, Naoko Takebe
Publikováno v:
Human Gene Therapy. 14:435-446
Gene transfer-based myeloprotection strategies against chemotherapy require the development of effective drug resistance genes or gene combinations. Our laboratory has previously generated drug-resistant mutants of dihydrofolate reductase (DHFR F/S)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadcdab4f530843cd73be3043b7512ef
https://doi.org/10.1089/104303403321467207
https://doi.org/10.1089/104303403321467207
Publikováno v:
Molecular Medicine. 7:200-204
The G52S mutation in the Arg50 loop of thymidylate synthase leads to decreased binding of FdUMP. It has been suggested that the mutation affects the Arg50 residue (within the Arg50 loop) responsible for binding the phosphate of FdUMP. The binding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ce2c46b810c2dd5d1f0ad85e2516d37
https://doi.org/10.1007/bf03401954
https://doi.org/10.1007/bf03401954
Autor:
Xinyue Liu-Chen, Youzhi Tong, Emine A. Ercikan-Abali, Shi-Cheng Zhao, Gina M. Capiaux, Debabrata Banerjee, Joseph R. Bertino
Publikováno v:
Journal of Biological Chemistry. 273:11611-11618
Thymidylate synthase plays an essential role in the synthesis of DNA. Recently, several new and specific thymidylate synthase inhibitors that occupy the folate binding site, including Tomudex(R), BW1843U89, and Thymitaq, have demonstrated therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df667dc518015a99047777854f3d21a4
https://doi.org/10.1074/jbc.273.19.11611
https://doi.org/10.1074/jbc.273.19.11611
Autor:
Debabrata Banerjee, Gina M. Capiaux, Naoko Takebe, Onder Alpdogan, Tulin Budak-Alpdogan, William Bornmann, Joseph R. Bertino, Frank Maley
Publikováno v:
Cancer gene therapy. 11(12)
Myelosuppression is one of the major side effects of most anticancer drugs. To confer myeloprotection, our laboratory generated drug-resistant mutants of select target human enzymes for gene transfer to the bone marrow. Mutants of two of these enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67f60555b3a933d06f645151cb4c50d
https://pubmed.ncbi.nlm.nih.gov/15359285
https://pubmed.ncbi.nlm.nih.gov/15359285
Autor:
Owen A. O'Connor, Naoko Takebe, Youzhi Tong, Emine A. Ercikan-Abali, Xinyue Liu-Chen, Debabrata Banerjee, Gina M. Capiaux, Joseph R. Bertino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326da530c5ee6718db32a0afba5b6734
https://doi.org/10.1159/000061991
https://doi.org/10.1159/000061991
Autor:
Gina M. Capiaux, Tulin Budak-Alpdogan, Naoko Takebe, Philipp Mayer-Kuckuk, Debabrata Banerjee, Frank Maley, Joseph R. Bertino
Publikováno v:
Human Gene Therapy; 3/20/2003, Vol. 14 Issue 5, p435-446, 12p
Autor:
Joseph R. Bertino, Debabrata Banerjee, Philipp Mayer-Kuckuk, Richard Gorlick, Tulin Budak-Alpdogan, Gina M. Capiaux
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (2-3):164-173
Drug resistance is often a limiting factor in successful chemotherapy. Our laboratory has been interested in studying mechanisms of resistance to drugs that are targeted to the thymidylate biosynthesis pathway especially those that target thymidylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea589be68a9c24b03f743b746809929