Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gina M LoMastro"'
Autor:
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland
Publikováno v:
eLife, Vol 11 (2022)
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplifica
Externí odkaz:
https://doaj.org/article/9b935ae6420c4b089c0ec2c10ac8a1e5
Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity
Autor:
Marina A. Schapfl, Gina M. LoMastro, Vincent Z. Braun, Maretoshi Hirai, Michelle S. Levine, Eva Kiermaier, Verena Labi, Andrew J. Holland, Andreas Villunger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Centrioles define centrosome structure and function. Deregulation of centriole numbers can cause developmental defects and cancer. The p53 tumor suppressor limits the growth of cells lacking or harboring additional centrosomes and can be eng
Externí odkaz:
https://doaj.org/article/019d4fb19cb64cd6834d48d84c0fafe0
Autor:
Valentina C, Sladky, Hanan, Akbari, Daniel, Tapias-Gomez, Lauren T, Evans, Chelsea G, Drown, Margaret A, Strong, Gina M, LoMastro, Tatianna, Larman, Andrew J, Holland
Publikováno v:
Genes & Development. 36:843-856
Hepatocyte polyploidization is a tightly controlled process that is initiated at weaning and increases with age. The proliferation of polyploid hepatocytes in vivo is restricted by the PIDDosome–P53 axis, but how this pathway is triggered remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6619c3ddcc45fb757876538a4140078
https://doi.org/10.1101/gad.349727.122
https://doi.org/10.1101/gad.349727.122
Autor:
Olivier Mercey, Alice Meunier, Eva J. Brotslaw, Michelle S. Levine, Andrew J. Holland, Brian J. Mitchell, Nathalie Spassky, Philippe Rostaing, Abhijay Kumar, Gina M. LoMastro, Valerie Gomez
Publikováno v:
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2019, ⟨10.1038/s41556-019-0427-x⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2019, ⟨10.1038/s41556-019-0427-x⟩
Nature cell biology
International audience; Multiciliated cells (MCCs) amplify large numbers of centrioles that convert into basal bodies, which are required for producing multiple motile cilia. Most centrioles amplified by MCCs grow on the surface of organelles called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efe3c46261e3862c13e4fedcf6f9fdc
https://hal.archives-ouvertes.fr/hal-02403074/document
https://hal.archives-ouvertes.fr/hal-02403074/document
Autor:
Gina M. LoMastro, Andrew J. Holland
Publikováno v:
Dev Cell
Centrosome aberrations are commonly observed in human tumors and correlate with tumor aggressiveness and poor prognosis. Extra centrosomes drive mitotic errors that have been implicated in promoting tumorigenesis in mice. However, centrosome aberrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7f595251def2f08577efbb059e2091
https://pubmed.ncbi.nlm.nih.gov/31063752
https://pubmed.ncbi.nlm.nih.gov/31063752