Topological properties and in vitro identification of essential nodes of the Paclitaxel and Vincristine interactomes in PC-3 cells

Autor: Claudia Delgado-Carreño, Gina Méndez-Callejas

Publikováno v: Biomedical Journal, Vol 42, Iss 5, Pp 307-316 (2019)

Background: Microtubule-targeting agents (MTAs) disrupt microtubule dynamics, thereby inducing apoptosis via mitochondrial pathway activation through the modulation in the expression of the Bcl-2 family. Methods: To describe topological features of t

Externí odkaz: https://doaj.org/article/c0d1ab83e08e4cbfbd367da9b7e127b1

Rapid evolution of the Helicobacter pylori AlpA adhesin in a high gastric cancer risk region from Colombia

Autor: Andrés Julián Gutiérrez-Escobar, Gina Méndez-Callejas, Orlando Acevedo, Maria Mercedes Bravo

Publikováno v: PeerJ, Vol 6, p e4846 (2018)

To be able to survive, Helicobacter pylori must adhere to the gastric epithelial cells of its human host. For this purpose, the bacterium employs an array of adhesins, for example, AlpA. The adhesin AlpA has been proposed as a major adhesin because o

Externí odkaz: https://doaj.org/article/11f7ec18f1a24ee7b23de091ec8e01a0

Caryophyllene Oxide, the Active Compound Isolated from Leaves of Hymenaea courbaril L. (Fabaceae) with Antiproliferative and Apoptotic Effects on PC-3 Androgen-Independent Prostate Cancer Cell Line

Autor: Crispin Celis, Claudia Delgado, Gina Méndez-Callejas

Publikováno v: Molecules
Volume 26
Issue 20
Repositorio Institucional UDCA
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
instacron:Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
Molecules, Vol 26, Iss 6142, p 6142 (2021)

Cancer treatment frequently carries side effects, therefore, the search for new selective and effective molecules is indispensable. Hymenaea courbaril L. has been used in traditional medicine in South America to treat several diseases, including pros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c94f3dceac6b3ade39259600644f16b

Interactome Analysis of Microtubule-targeting Agents Reveals Cytotoxicity Bases in Normal Cells

Autor: Gina Méndez-Callejas, Andrés Julián Gutiérrez-Escobar

Publikováno v: Genomics, Proteomics & Bioinformatics, Vol 15, Iss 6, Pp 352-360 (2017)
Genomics, Proteomics & Bioinformatics
Repositorio Institucional UDCA
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
instacron:Universidad de Ciencias Aplicadas y Ambientales U.D.C.A

Cancer causes millions of deaths annually and microtubule-targeting agents (MTAs) are the most commonly-used anti-cancer drugs. However, the high toxicity of MTAs on normal cells raises great concern. Due to the non-selectivity of MTA targets, we ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2905ebce603e1e66ed1116a3bb7fdee4
http://www.sciencedirect.com/science/article/pii/S1672022917301717

Natural 2′,4-Dihydroxy-4′,6′-dimethoxy Chalcone Isolated from Chromolaena tacotana Inhibits Breast Cancer Cell Growth through Autophagy and Mitochondrial Apoptosis

Autor: Gina Mendez-Callejas, Marco Piñeros-Avila, Crispin A. Celis, Ruben Torrenegra, Anderson Espinosa-Benitez, Roberto Pestana-Nobles, Juvenal Yosa-Reyes

Publikováno v: Plants, Vol 13, Iss 5, p 570 (2024)

Breast cancer (BC) is one of the most common cancers among women. Effective treatment requires precise tailoring to the genetic makeup of the cancer for improved efficacy. Numerous research studies have concentrated on natural compounds and their ant

Externí odkaz: https://doaj.org/article/0b9533d8da7c490b81d3b7ece70c9496