Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Gina M, Doody"'
Autor:
Beibei Wu, Laura Rice, Jennifer Shrimpton, Dylan Lawless, Kieran Walker, Clive Carter, Lynn McKeown, Rashida Anwar, Gina M Doody, Sonal Srikanth, Yousang Gwack, Sinisa Savic
Publikováno v:
eLife, Vol 10 (2021)
CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and activation of the Ca2+-NFAT and JNK-AP1 pathways. CRACR2A has been linked to h
Externí odkaz:
https://doaj.org/article/3bc52deffd5148cea866655819e240e0
Publikováno v:
Cancers; Volume 15; Issue 12; Pages: 3083
Epstein-Barr virus (EBV)-driven B cell neoplasms arise from the reactivation of latently infected B cells. In a subset of patients, EBV was seen to drive a polymorphous lymphoproliferative disorder (LPD) in which B cell differentiation was retained.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::e3fe39382835bf0b3da90d75dc260c4a
Autor:
Kieran Walker, Anoop Mistry, Christopher M. Watson, Fatima Nadat, Eleanor O’Callaghan, Matthew Care, Laura A. Crinnion, Gururaj Arumugakani, David T. Bonthron, Clive Carter, Gina M. Doody, Sinisa Savic
Publikováno v:
Journal of Clinical Immunology.
Background The human CD19 antigen is expressed throughout B cell ontogeny with the exception of neoplastic plasma cells and a subset of normal plasma cells. CD19 plays a role in propagating signals from the B cell receptor and other receptors such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06dd910ddcde948864b1d47a96eaf504
https://doi.org/10.1007/s10875-023-01511-w
https://doi.org/10.1007/s10875-023-01511-w
Autor:
Rebecca J Brownlie, Ruth Kennedy, Erica B Wilson, Maja Milanovic, Claire F Taylor, Dapeng Wang, John Davies, Heather Elizabeth Owston, Emma J Adams, Sophie Stephenson, Rebecca Caeser, Benjamin E Gewurz, Peter V Giannoudis, Claudio Scuoppo, Dennis McGonagle, Daniel J Hodson, Reuben M Tooze, Gina M Doody, Gordon Cook, David R Westhead, Ulf Klein
Publikováno v:
Blood Advances.
Multiple myeloma (MM) shows constitutive activation of canonical and non-canonical nuclear factor-ĸB (NF-ĸB) signaling through genetic mutations or stimuli from the tumour microenvironment (TME). A subset of MM cell lines showed dependency for cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd7a05ed7694f34e461dca36e4bc6a7
https://doi.org/10.1182/bloodadvances.2022009044
https://doi.org/10.1182/bloodadvances.2022009044
Autor:
Emily Robinson, Matthew A. Care, Kieran Walker, Michelle Campbell, Reuben M. Tooze, Gina M. Doody
Publikováno v:
The Journal of Immunology. 208:514-525
Upon encounter with Ag, B cells undergo a sequential process of differentiation to become Ab-secreting plasma cells. Although the key drivers of differentiation have been identified, research has been limited by the lack of in vitro models recapitula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1abcd350ab63dfaf144688c7f7c87714
https://doi.org/10.4049/jimmunol.2100004
https://doi.org/10.4049/jimmunol.2100004
Autor:
Amber M.L. Emmett, Amel Saadi, Matthew A. Care, Gina M. Doody, Reuben M. Tooze, David R. Westhead
Human B cell differentiation into antibody secreting plasma cells is a critical process in the adaptive immune response, whose regulation at the genetic level remains incompletely understood. To reveal the temporal sequence of transcription factor dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dfdb1cbb52bf63cdc4fe499851e83cf
https://doi.org/10.1101/2023.01.09.522862
https://doi.org/10.1101/2023.01.09.522862
Autor:
Sophie Stephenson, Gina M. Doody
Publikováno v:
Methods in Molecular Biology ISBN: 9781071632468
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460e19aa7ab630429b72016cbd7b1739
https://doi.org/10.1007/978-1-0716-3247-5_20
https://doi.org/10.1007/978-1-0716-3247-5_20
Autor:
Kieran Walker, Anoop Mistry, Christopher M Watson, Fatima Nadat, Laura A Crinnion, Gururaj Arumugakani, David T Bonthron, Clive Carter, Gina M Doody, Sinisa Savic
Background: The human CD19 antigen is expressed throughout B cell ontogeny with the exception of neoplastic plasma cells and a subset of normal plasma cells. CD19 plays a role in propagating signals from the B cell receptor and other receptors such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::200c47d012f26e0e9cca3ef1a6ed8394
https://doi.org/10.21203/rs.3.rs-1498757/v1
https://doi.org/10.21203/rs.3.rs-1498757/v1
Autor:
Mark Kacar, Jennifer K. Shrimpton, Miriam Jassam, Anoop Mistry, Gururaj Arumugakani, Alexandros Grammatikos, Mark Gompels, Gina M. Doody, Sinisa Savic
Publikováno v:
Scandinavian Journal of Immunology. 96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c491725019c45de430ecf3892591cecb
https://doi.org/10.1111/sji.13155
https://doi.org/10.1111/sji.13155
Autor:
Sinisa Savic, James A. Poulter, Andrew J. Cant, Eamonn Sheridan, Helen Griffin, Dylan Lawless, Sophie Hambleton, Neil V. Morgan, Stefan Przyborski, Siti Mardhiana Mohamad, Rashida Anwar, Jennifer Shrimpton, Clive Carter, Gina M. Doody, Karin R. Engelhardt, Kevin Windebank, Meghan Acres, Catherine Cargo, Stephan Ehl, Frédéric Rieux-Laucat, Chris M. Bacon, Sean O’Riordan, Anne Rensing-Ehl, Jarmila Stremenova Spegarova, Majlinda Lako, Philip Chetcuti, Aneta Mikulasova
Publikováno v:
Blood. 136:1055-1066
Molecular dissection of inborn errors of immunity can help to elucidate the nonredundant functions of individual genes. We studied 3 children with an immune dysregulation syndrome of susceptibility to infection, lymphadenopathy, hepatosplenomegaly, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90025e03a10adb11ab54564e2391eb9
https://doi.org/10.1182/blood.2020005844
https://doi.org/10.1182/blood.2020005844