Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gina Leisching"'
Autor:
Abhilasha Madhvi, Hridesh Mishra, Novel N. Chegou, Gerard Tromp, Carel J. Van Heerden, R. D. Pietersen, Gina Leisching, Bienyameen Baker
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 170-182 (2020)
The comparison of the host immune response when challenged with pathogenic and nonpathogenic species of mycobacteria can provide answers to the unresolved question of how pathogens subvert or inhibit an effective response. We infected human monocyte
Externí odkaz:
https://doaj.org/article/655a5e9797a442a49fce39cc6dbda58a
Autor:
Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Morgane Mitermite, Dearbhla M. Murphy, Gina Leisching, Lorraine Thong, Seónadh M. O’Leary, Karl M. Gogan, Kate McQuaid, Amy M. Coleman, Stephen V. Gordon, Sharee A. Basdeo, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact
Externí odkaz:
https://doaj.org/article/a9b01451cc7f44639429c99ff0a2bc3b
Publikováno v:
International Journal of Infectious Diseases, Vol 80, Iss , Pp S77-S84 (2019)
The 2′,5′ (OASs) are known as mediators of the antiviral response system through activation of the RNA cleavage pathway. Interestingly, we observe OAS1, OAS2 and OAS3 upregulation in a number of gene expression signatures which discriminate activ
Externí odkaz:
https://doaj.org/article/df7b33037a16485f8055dc2e7e455443
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
The type I IFN response quickly became associated with its role in the innate immune response to viral infection. The past few years have seen the significance of IFNs expand in breadth to include non-viral pathogens. Previous work has identified tha
Externí odkaz:
https://doaj.org/article/a1387c37cc604135843addefe43b86be
Autor:
Gina Leisching, Ray-Dean Pietersen, Vuyiseka Mpongoshe, Carel van Heerden, Paul van Helden, Ian Wiid, Bienyameen Baker
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153079 (2016)
During Mycobacterium tuberculosis (M.tb) infection, the initial interactions between the pathogen and the host cell determines internalization and innate immune response events. It is established that detergents such as Tween alter the mycobacterial
Externí odkaz:
https://doaj.org/article/0480dddccbfe45f3b5e1ceb9beec63a8
Publikováno v:
Lupus. 32:603-611
The association of dysregulated metabolism in systemic lupus erythematosus (SLE) pathogenesis has prompted investigations into metabolic rewiring and the involvement of mitochondrial metabolism as a driver of disease through NLRP3 inflammasome activa
Autor:
Anjali S. Yennemadi, Gráinne Jameson, Mary Glass, Carolina De Pasquale, Joseph Keane, Massimiliano Bianchi, Gina Leisching
Although clinically effective, the actions of IFNα, either produced endogenously or by therapeutic delivery, remain poorly understood. Emblematic of this research gap is the disparate array of notable side effects that occur in susceptible individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50556d21e4fc37ea0acdd1530838f19f
https://doi.org/10.1101/2022.10.17.512487
https://doi.org/10.1101/2022.10.17.512487
Autor:
Andrea Gutschmidt, Candice I. Snyders, Dannielle K Moore, Gina Leisching, Ilana C. van Rensburg, Andre G. Loxton
Publikováno v:
Immunity, Inflammation and Disease
Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 458-467 (2020)
Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 458-467 (2020)
Introduction B‐cells are essential in the defense against Mycobacterium tuberculosis. Studies on isolated cells may not accurately reflect the responses that occur in vivo due to the presence of other cells. This study elucidated the influence of m
Autor:
Gina Leisching, Abhilasha Madhvi, R D Pietersen, Bienyameen Baker, Novel N. Chegou, Hridesh Mishra, Gerard Tromp, Carel J. van Heerden
Publikováno v:
Virulence
Virulence, Vol 11, Iss 1, Pp 170-182 (2020)
Virulence, Vol 11, Iss 1, Pp 170-182 (2020)
The comparison of the host immune response when challenged with pathogenic and nonpathogenic species of mycobacteria can provide answers to the unresolved question of how pathogens subvert or inhibit an effective response. We infected human monocyte
Autor:
Seónadh O'Leary, Kate McQuaid, Lorraine Thong, Joseph Keane, Stephen V. Gordon, Gina Leisching, Dearbhla M. Murphy, Morgane Mitermite, Cilian Ó Maoldomhnaigh, Karl M. Gogan, Sharee A. Basdeo, Donal J. Cox, James J. Phelan, Amy M. Coleman
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact