Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gina J Walter"'
Autor:
Ruth Scheicher, Anca S. Tigan, Florian Bellutti, Stefan Fröhling, Stefan Kubicek, Iris Z. Uras, Peter Valent, Gina J. Walter, Claudia Scholl, Michaela Prchal-Murphy, Florian H. Heidel, Veronika Sexl
Publikováno v:
Blood. 127:2890-2902
Up to 30% of patients with acute myeloid leukemia have constitutively activating internal tandem duplications (ITDs) of the FLT3 receptor tyrosine kinase. Such mutations are associated with a poor prognosis and a high propensity to relapse after remi
Autor:
Veerle Fleskens, Leonie S. Taams, Bina Menon, Megha Rajasekhar, Jens Gerwien, Gina J Walter, Hayley G. Evans, Klaus Stensgaard Frederiksen
Publikováno v:
Arthritis & Rheumatology. 68:103-116
Objective Conflicting evidence exists regarding the suppressive capacity of Treg cells in the peripheral blood (PB) of patients with rheumatoid arthritis (RA). The aim of this study was to determine whether Treg cells are intrinsically defective in R
Autor:
Megha Rajasekhar, Leonie S. Taams, Nicola J. Gullick, Gina J Walter, Toby Garrood, Bruce Kirkham, Bina Menon, Hayley G. Evans
Publikováno v:
Arthritis & Rheumatology. 66:1272-1281
Psoriatic arthritis (PsA) is an inflammatory joint disease of unclear etiology that affects ∼10–30% of patients with the skin condition psoriasis (1). Although PsA, like rheumatoid arthritis (RA), can result in pain, loss of function, and damage
Autor:
Frederic Geissmann, Hayley G. Evans, Leonie S. Taams, Gina J Walter, Andrew P. Cope, Nicola J. Gullick, Bina Menon, Bruce Kirkham
Publikováno v:
Arthritis & Rheumatism
Immune regulation is essential for the maintenance of peripheral tolerance, prevention of autoimmune diseases and the limitation of chronic inflammation. Human CD4+CD25+CD127low regulatory T cells (Tregs), characterised by the expression of the linea
Autor:
Alastair Gracie, Gina J Walter, Nicola J. Gullick, Lucy E Ballantine, Bina Menon, Frédéric Rieux-Laucat, Aude Magerus-Chatinet, Hayley G. Evans, Machteld M. Tiemessen, Leonie S. Taams, Frederic Geissmann, Ann L. Jagger
Publikováno v:
Journal of Autoimmunity
Conclusive resolution of an immune response is critical for the prevention of autoimmunity and chronic inflammation. We report that following co-culture with autologous CD4+CD25- responder T cells, human CD14+ monocytes and monocyte-derived macrophag
Publikováno v:
Expert Review of Clinical Immunology. 7:499-514
Systemic sclerosis (SSc) is a generalized connective tissue disorder, characterized by a wide spectrum of microvascular and immunological abnormalities, leading to a progressive thickening and fibrosis of the skin and other organs, such as the lungs,
Autor:
Andrew P. Cope, Hayley G. Evans, Urmas Roostalu, Ceri A. Roberts, Leonie S. Taams, Gina J Walter, Nicola J. Gullick, Jens Gerwien, Dominique Baeten, Frederic Geissmann, Jonathan Sumner, Bruce Kirkham, Klaus Stensgaard Frederiksen
Publikováno v:
Nature communications, 5. Nature Publishing Group
Nature communications
Nature communications
IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6e4a5c43d158c0b365c3d9c8e6e432
https://doi.org/10.1038/ncomms4199
https://doi.org/10.1038/ncomms4199
Autor:
Bina, Menon, Nicola J, Gullick, Gina J, Walter, Megha, Rajasekhar, Toby, Garrood, Hayley G, Evans, Leonie S, Taams, Bruce W, Kirkham
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 66(5)
Psoriatic arthritis (PsA) is associated with HLA class I genes, in contrast to the association with HLA class II in rheumatoid arthritis (RA). Since IL-17+ cells are considered important mediators of synovial inflammation, we sought to determine whet
Autor:
Leonie S. Taams, Jens Gerwien, Frederic Geissmann, Urmas Roostalu, Andrew P. Cope, Hayley G. Evans, Gina J Walter, Bruce Kirkham, Klaus Stensgaard Frederiksen, Nicola J. Gullick
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 10, Iss Suppl 3, p P49 (2012)
Journal of Translational Medicine, Vol 10, Iss Suppl 3, p P49 (2012)
Results Ex vivo analysis of patients with RA on TNFi therapy revealed an enrichment of Th17 cells in peripheral blood compared to those on disease-modifying anti-rheumatic drugs or healthy controls. However, we also found an increase in IL-10-produci
Autor:
Hayley G. Evans, Andrew P. Cope, Leonie S. Taams, Frederic Geissmann, Gina J Walter, Bruce Kirkham, Bina Menon
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 10, Iss Suppl 3, p P3 (2012)
Journal of Translational Medicine, Vol 10, Iss Suppl 3, p P3 (2012)
Despite the high frequency of CD4+ T cells with a regulatory phenotype (CD25+CD127lowFoxP3+) in the joints of patients with rheumatoid arthritis (RA), inflammation persists. Regulatory T cells (Tregs) can be converted into pro-inflammatory IL-17-prod