Výsledky vyhledávání - "Gina F Marrone"

Genetic dissociation of morphine analgesia from hyperalgesia in mice

Autor: Jin Xu, Susruta Majumdar, Valerie Le Rouzic, Anjali M. Rajadhyaksha, András Váradi, Ying-Xian Pan, Gina F. Marrone, Gavril W. Pasternak

Publikováno v: Psychopharmacology. 234:1891-1900

Morphine is the prototypic mu opioid, producing its analgesic actions through traditional 7 transmembrane domain (7TM) G-protein-coupled receptors generated by the mu opioid receptor gene (Oprm1). However, the Oprm1 gene undergoes extensive alternati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a6781764769eb326eace8e07cfd126
https://doi.org/10.1007/s00213-017-4600-2

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Tetrapeptide Endomorphin Analogs Require Both Full Length and Truncated Splice Variants of the Mu Opioid Receptor Gene Oprm1 for Analgesia

Autor: Ankita Narayan, Ying-Xian Pan, Zhigang Lu, Amanda Hunkele, Sarah Marx, John E. Pintar, Jin Xu, Gina F. Marrone, Susruta Majumdar, Grace C. Rossi, Gavril W. Pasternak

Publikováno v: ACS Chemical Neuroscience. 7:1717-1727

The mu opioid receptor gene undergoes extensive alternative splicing. Mu opioids can be divided into three classes based on the role of different groups of splice variants. Morphine and methadone require only full length 7 transmembrane (7TM) variant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844562052a614a87060cc95be62ec744
https://doi.org/10.1021/acschemneuro.6b00240

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Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

Publikováno v: Journal of Medicinal Chemistry. 59:8381-8397

Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand opioid pharmacology. Herein, we repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94a35e55b45ec92a90c2a69f4766534
https://doi.org/10.1021/acs.jmedchem.6b00748

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Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants

Autor: Ying-Xian Pan, Grace C. Rossi, John E. Pintar, Michael Ansonoff, Zhigang Lu, Ankita Narayan, Daniel L. Bassoni, Steven G. Grinnell, Jin Xu, Gina F. Marrone, Gavril W. Pasternak, Susruta Majumdar

Publikováno v: Synapse. 70:395-407

Buprenorphine has long been classified as a mu analgesic, although its high affinity for other opioid receptor classes and the orphanin FQ/nociceptin ORL1 receptor may contribute to its other actions. The current studies confirmed a mu mechanism for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4248c6c20628aa06bc5af32bbc812a94
https://doi.org/10.1002/syn.21914

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Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS

Autor: Grace C. Rossi, Valerie Le Rouzic, Jin Xu, Susruta Majumdar, Gavril W. Pasternak, Gina F. Marrone, Zhigang Lu, Ying-Xian Pan, Steven G. Grinnell

Publikováno v: Proceedings of the National Academy of Sciences. 113:3663-3668

The clinical management of severe pain depends heavily on opioids acting through mu opioid receptors encoded by the Oprm1 gene, which undergoes extensive alternative splicing. In addition to generating a series of prototypic seven transmembrane domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b085808aba5e6f0c887ead0d50b0e4
https://doi.org/10.1073/pnas.1523894113

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Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior

Autor: Jay P. McLaughlin, András Váradi, Gavril W. Pasternak, Michelle L. Ganno, Shainnel O. Eans, Valerie Le Rouzic, Gina F. Marrone, Susruta Majumdar, Amanda Hunkele, Joan J. Subrath

Publikováno v: ACS Chemical Neuroscience. 6:1813-1824

3-Iodobenzoyl naltrexamine (IBNtxA) is a potent analgesic belonging to the pharmacologically diverse 6β-amidoepoxymorphinan group of opioids. We present the synthesis and pharmacological evaluation of five analogs of IBNtxA. The scaffold of IBNtxA w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c1b69f364444cf219f1893c9699003
https://doi.org/10.1021/acschemneuro.5b00153

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Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction

Autor: Travis C. Palmer, Gavril W. Pasternak, Nathan Haselton, András Váradi, Valerie Le Rouzic, Joan J. Subrath, Attila Borics, Susruta Majumdar, Amanda Hunkele, Gina F. Marrone, Daniel Afonin

Publikováno v: ACS Chemical Neuroscience. 6:1570-1577

We report a novel approach to synthesize carfentanil amide analogues utilizing the isocyanide-based four-component Ugi multicomponent reaction. A small library of bis-amide analogues of carfentanil was created using N-alkylpiperidones, aniline, propi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4325f9563198222495feb34e0262e2a9
https://doi.org/10.1021/acschemneuro.5b00137

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Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA) and Its Pharmacodynamic Consequences in the Rat

Autor: Gina F. Marrone, Marilyn A. Huestis, Karl B. Scheidweiler, Marta Concheiro, Richard B. Rothman, Michael H. Baumann

Publikováno v: Drug Metabolism and Disposition. 42:119-125

3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug that can cause severe and even fatal adverse effects. However, interest remains for its possible clinical applications in posttraumatic stress disorder and anxiety treatment. Pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155a51f3960d70c8d1f75579ebc6cdc8
https://doi.org/10.1124/dmd.113.053678

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Stress differentially alters mu opioid receptor density and trafficking in parvalbumin-containing interneurons in the female and male rat hippocampus

Autor: Keith L. Gonzales, Annelyn Torres-Reveron, Suzanne R. Burstein, Teresa A. Milner, Kathryn C. Schierberl, Gina F. Marrone, Elizabeth M. Waters, Bruce S. McEwen, Andreina D. Gonzalez, Sana Khalid, Tanya J. Williams

Publikováno v: Synapse. 67:757-772

Stress differentially affects hippocampal-dependent learning relevant to addiction and morphology in male and female rats. Mu opioid receptors (MORs), which are located in parvalbumin (PARV)-containing GABAergic interneurons and are trafficked in res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43e8f648c78b5e96ac469b8b02a0f30c
https://doi.org/10.1002/syn.21683

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Oral Fluid Nicotine Markers to Assess Smoking Status and Recency of Use

Autor: Gina F Marrone, Edward G. Singleton, Stephen J. Heishman, Karl B. Scheidweiler, Diaa M. Shakleya, Marilyn A. Huestis

Publikováno v: Therapeutic Drug Monitoring. 33:609-618

Oral fluid collection is noninvasive and easily observed making it an attractive matrix for objectively determining smoking status. Despite large intersubject variability, cotinine oral fluid concentrations correlate with cigarettes smoked per day (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70b16618e3edee89f3af9d384134064
https://doi.org/10.1097/ftd.0b013e318228ba39

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