Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Gina E. Sosinsky"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2015)
Pannexin2 (Panx2) is the largest of three members of the pannexin proteins. Pannexins are topologically related to connexins and innexins, but serve different functional roles than forming gap junctions. We previously showed that pannexins form oligo
Externí odkaz:
https://doaj.org/article/0c88f6b415744a0898810f5435fadc7a
Autor:
Cinzia Ambrosi, Cynthia Ren, Gaelle Spagnol, Gabriel Cavin, Angela Cone, Elena E Grintsevich, Gina E Sosinsky, Paul L Sorgen
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157073 (2016)
Gap junctions are membrane specialization domains identified in most tissue types where cells abut each other. The connexin channels found in these membrane domains are conduits for direct cell-to-cell transfer of ions and molecules. Connexin43 (Cx43
Externí odkaz:
https://doaj.org/article/c9314dfee01342acaed97132d1f09872
Autor:
Jennifer R. Baum, Daniela Boassa, Elena Dolmatova, Cinzia Ambrosi, Maria I. Kontaridis, Gina E. Sosinsky, Heather S. Duffy, Paul L. Sorgen, Gaelle Spagnol, Kimberly Keith
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 303:H1208-H1218
Fibrosis following myocardial infarction is associated with increases in arrhythmias and sudden cardiac death. Initial steps in the development of fibrosis are not clear; however, it is likely that cardiac fibroblasts play an important role. In immun
Autor:
Sezgi Arpag, Hauke B. Werner, Xuebao Zhang, Gina E. Sosinsky, Mark H. Ellisman, Bo Hu, Yang Zhang, Jonathan Chernoff, Audra Hamilton, Jun Li, Wiebke Möbius
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 9, p e1006290 (2016)
PLoS Genetics, Vol 12, Iss 9, p e1006290 (2016)
Schwann cells in the peripheral nervous systems extend their membranes to wrap axons concentrically and form the insulating sheath, called myelin. The spaces between layers of myelin are sealed by myelin junctions. This tight insulation enables rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cd293e6acef2b6580acd8e02107b93
https://hdl.handle.net/11858/00-001M-0000-002D-70D9-211858/00-001M-0000-002D-70D7-6
https://hdl.handle.net/11858/00-001M-0000-002D-70D9-211858/00-001M-0000-002D-70D7-6
Autor:
Gina E. Sosinsky, Vamsi K. Mootha, Thomas L. Poulos, Yasemin Sancak, Alice Y. Ting, Jeffrey D. Martell, Mark H. Ellisman, Thomas J. Deerinck
Publikováno v:
Nature Biotechnology. 30:1143-1148
Electron microscopy (EM) is the standard method for imaging cellular structures with nanometer resolution, but existing genetic tags are inactive in most cellular compartments or require light and can be difficult to use. Here we report the developme
Autor:
Xing-Hua Yao, Song-Hai Shi, Shuijin He, Gina E. Sosinsky, Keith N. Brown, Jian Ma, Yinghui Fu, Kate P. Gao, Yong-Chun Yu, She Chen, Kun Huang
Publikováno v:
Nature. 486:113-117
In the neocortex, microcircuits are assembled in a lineage-dependent manner through a distinct sequence of events that involves long-range electrical connections between sister neurons, leading to the formation of chemical synapses between these neur
Autor:
Sayaka Inukai, Gina E. Sosinsky, Amy Smock, Yoko Hiroaki, Angela C. Cone, Bruce J. Nicholson, Atsunori Oshima, Masoud M. Toloue, Kazutoshi Tani, Yoshinori Fujiyoshi
Publikováno v:
Journal of Molecular Biology. 405:724-735
Gap junction channels are unique in that they possess multiple mechanisms for channel closure, several of which involve the N terminus as a key component in gating, and possibly assembly. Here, we present electron crystallographic structures of a mut
Autor:
Daniela Boassa, Gina E. Sosinsky, Perry J. Thornton, Paul D. Lampe, Joell L. Solan, Adrian Papas
Publikováno v:
Traffic. 11:1471-1486
During the cell cycle, gap junction communication, morphology and distribution of connexin43 (Cx43)-containing structures change dramatically. As cells round up in mitosis, Cx43 labeling is mostly intracellular and intercellular coupling is reduced.
Autor:
Jennifer Pranskevich, Gerhard Dahl, Junjie Wang, Daniela Boassa, Cinzia Ambrosi, Gina E. Sosinsky, Claudia Steinem, Amy Smock, Oliver Gassmann
Publikováno v:
Journal of Biological Chemistry. 285:24420-24431
Pannexins are homologous to innexins, the invertebrate gap junction family. However, mammalian pannexin1 does not form canonical gap junctions, instead forming hexameric oligomers in single plasma membranes and intracellularly. Pannexin1 acts as an A
Autor:
Bruce J. Nicholson, Gina E. Sosinsky, Jennifer Pranskevich, Atsunori Oshima, Cinzia Ambrosi, Ji Xu, Amy Smock, Daniela Boassa
Publikováno v:
Biophysical Journal. 98:1809-1819
Connexin26 is a ubiquitous gap junction protein that serves critical homeostatic functions. Four single-site mutations found in the transmembrane helices (M1–M4) cause different types of dysfunctional channels: 1), Cx26T135A in M3 produces a closed