Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Gina E Sosinsky"'
Autor:
Cinzia Ambrosi, Cynthia Ren, Gaelle Spagnol, Gabriel Cavin, Angela Cone, Elena E Grintsevich, Gina E Sosinsky, Paul L Sorgen
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157073 (2016)
Gap junctions are membrane specialization domains identified in most tissue types where cells abut each other. The connexin channels found in these membrane domains are conduits for direct cell-to-cell transfer of ions and molecules. Connexin43 (Cx43
Externí odkaz:
https://doaj.org/article/c9314dfee01342acaed97132d1f09872
Autor:
Cinzia Ambrosi, Amy E Walker, Adam D Depriest, Angela C Cone, Connie Lu, John Badger, I Martha Skerrett, Gina E Sosinsky
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70916 (2013)
Human Connexin26 gene mutations cause hearing loss. These hereditary mutations are the leading cause of childhood deafness worldwide. Mutations in gap junction proteins (connexins) can impair intercellular communication by eliminating protein synthes
Externí odkaz:
https://doaj.org/article/281d61dfc0ad4f86a660875601fecdc1
Autor:
Sezgi Arpag, Hauke B. Werner, Xuebao Zhang, Gina E. Sosinsky, Mark H. Ellisman, Bo Hu, Yang Zhang, Jonathan Chernoff, Audra Hamilton, Jun Li, Wiebke Möbius
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 9, p e1006290 (2016)
PLoS Genetics, Vol 12, Iss 9, p e1006290 (2016)
Schwann cells in the peripheral nervous systems extend their membranes to wrap axons concentrically and form the insulating sheath, called myelin. The spaces between layers of myelin are sealed by myelin junctions. This tight insulation enables rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cd293e6acef2b6580acd8e02107b93
https://hdl.handle.net/11858/00-001M-0000-002D-70D9-211858/00-001M-0000-002D-70D7-6
https://hdl.handle.net/11858/00-001M-0000-002D-70D9-211858/00-001M-0000-002D-70D7-6
Autor:
Jennifer R. Baum, Daniela Boassa, Elena Dolmatova, Cinzia Ambrosi, Maria I. Kontaridis, Gina E. Sosinsky, Heather S. Duffy, Paul L. Sorgen, Gaelle Spagnol, Kimberly Keith
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 303:H1208-H1218
Fibrosis following myocardial infarction is associated with increases in arrhythmias and sudden cardiac death. Initial steps in the development of fibrosis are not clear; however, it is likely that cardiac fibroblasts play an important role. In immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732d4256eecc7edeea6b9eab5eea71d3
https://doi.org/10.1152/ajpheart.00251.2012
https://doi.org/10.1152/ajpheart.00251.2012
Autor:
Gina E. Sosinsky, Vamsi K. Mootha, Thomas L. Poulos, Yasemin Sancak, Alice Y. Ting, Jeffrey D. Martell, Mark H. Ellisman, Thomas J. Deerinck
Publikováno v:
Nature Biotechnology. 30:1143-1148
Electron microscopy (EM) is the standard method for imaging cellular structures with nanometer resolution, but existing genetic tags are inactive in most cellular compartments or require light and can be difficult to use. Here we report the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c051a346b411f57d5c089c5209ce76b8
https://doi.org/10.1038/nbt.2375
https://doi.org/10.1038/nbt.2375
Autor:
Xing-Hua Yao, Song-Hai Shi, Shuijin He, Gina E. Sosinsky, Keith N. Brown, Jian Ma, Yinghui Fu, Kate P. Gao, Yong-Chun Yu, She Chen, Kun Huang
Publikováno v:
Nature. 486:113-117
In the neocortex, microcircuits are assembled in a lineage-dependent manner through a distinct sequence of events that involves long-range electrical connections between sister neurons, leading to the formation of chemical synapses between these neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b73ed9179d1b90610ac9c051a0aa5d7
https://doi.org/10.1038/nature10958
https://doi.org/10.1038/nature10958
Autor:
Sayaka Inukai, Gina E. Sosinsky, Amy Smock, Yoko Hiroaki, Angela C. Cone, Bruce J. Nicholson, Atsunori Oshima, Masoud M. Toloue, Kazutoshi Tani, Yoshinori Fujiyoshi
Publikováno v:
Journal of Molecular Biology. 405:724-735
Gap junction channels are unique in that they possess multiple mechanisms for channel closure, several of which involve the N terminus as a key component in gating, and possibly assembly. Here, we present electron crystallographic structures of a mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef22a7f3433391baefae9357edaaf750
https://doi.org/10.1016/j.jmb.2010.10.032
https://doi.org/10.1016/j.jmb.2010.10.032
Autor:
Daniela Boassa, Gina E. Sosinsky, Perry J. Thornton, Paul D. Lampe, Joell L. Solan, Adrian Papas
Publikováno v:
Traffic. 11:1471-1486
During the cell cycle, gap junction communication, morphology and distribution of connexin43 (Cx43)-containing structures change dramatically. As cells round up in mitosis, Cx43 labeling is mostly intracellular and intercellular coupling is reduced.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c723a094f1a905115a9cb7e967434f68
https://doi.org/10.1111/j.1600-0854.2010.01109.x
https://doi.org/10.1111/j.1600-0854.2010.01109.x
Autor:
Jennifer Pranskevich, Gerhard Dahl, Junjie Wang, Daniela Boassa, Cinzia Ambrosi, Gina E. Sosinsky, Claudia Steinem, Amy Smock, Oliver Gassmann
Publikováno v:
Journal of Biological Chemistry. 285:24420-24431
Pannexins are homologous to innexins, the invertebrate gap junction family. However, mammalian pannexin1 does not form canonical gap junctions, instead forming hexameric oligomers in single plasma membranes and intracellularly. Pannexin1 acts as an A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a35ffccb6b48cdfd40ae3746f76313
https://doi.org/10.1074/jbc.m110.115444
https://doi.org/10.1074/jbc.m110.115444
Autor:
Bruce J. Nicholson, Gina E. Sosinsky, Jennifer Pranskevich, Atsunori Oshima, Cinzia Ambrosi, Ji Xu, Amy Smock, Daniela Boassa
Publikováno v:
Biophysical Journal. 98:1809-1819
Connexin26 is a ubiquitous gap junction protein that serves critical homeostatic functions. Four single-site mutations found in the transmembrane helices (M1–M4) cause different types of dysfunctional channels: 1), Cx26T135A in M3 produces a closed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae719e51ef539cb6008d1971d6f0ffd
https://doi.org/10.1016/j.bpj.2010.01.019
https://doi.org/10.1016/j.bpj.2010.01.019