Zobrazeno 1 - 10 of 65 pro vyhledávání: '"Gina A. Smith"'
1
Akademický článek
Impact of cigarette versus electronic cigarette aerosol conditioned media on aortic endothelial cells in a microfluidic cardiovascular model
Autor: Om Makwana, Gina A. Smith, Hannah E. Flockton, Gary P. Watters, Frazer Lowe, Damien Breheny
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Atherosclerosis is a complex process involving progressive pathological events, including monocyte adhesion to the luminal endothelial surface. We have developed a functional in vitro adhesion assay using BioFlux microfluidic technology to i
Externí odkaz: https://doaj.org/article/2bff10ca82594bb2a0a8f3cd115024d0
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2
Akademický článek
Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Autor: Gina A. Smith, Gareth W. Fearnley, Izma Abdul-Zani, Stephen B. Wheatcroft, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
Publikováno v: Biology Open, Vol 6, Iss 10, Pp 1404-1415 (2017)
Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor
Externí odkaz: https://doaj.org/article/0083afd86eff426b9d979f5c7df686ce
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3
Akademický článek
VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
Autor: Gareth W. Fearnley, Gina A. Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A. Mughal, Shervanthi Homer-Vanniasinkam, Mark T. Kearney, Ian C. Zachary, Darren C. Tomlinson, Michael A. Harrison, Stephen B. Wheatcroft, Sreenivasan Ponnambalam
Publikováno v: Biology Open, Vol 5, Iss 5, Pp 571-583 (2016)
Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can
Externí odkaz: https://doaj.org/article/3e3d9e669a4f443da487cf76e60f7baf
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4
Akademický článek
Receptor tyrosine kinase structure and function in health and disease
Autor: Oleg A. Karpov, Gareth W. Fearnley, Gina A. Smith, Jayakanth Kankanala, Michael J. McPherson, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
Publikováno v: AIMS Biophysics, Vol 2, Iss 4, Pp 476-502 (2015)
Receptor tyrosine kinases (RTKs) are membrane proteins that control the flow of information through signal transduction pathways, impacting on different aspects of cell function. RTKs are characterized by a ligand-binding ectodomain, a single transme
Externí odkaz: https://doaj.org/article/58bd594031e341e1855696de9aa98863
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5
Spatial pattern of environmental perception and place attachment in a diverse socio-economic context: the case of Gauteng province, South Africa
Autor: Simangele Dlamini, Solomon G. Tesfamichael, Gina Weir-Smith, Tholang Mokhele
Publikováno v: Journal of Spatial Information Science. :89-111
There is limited consensus among researchers on whether the spatial distribution of environmental perceptions and place attachment is influenced by socio-economic factors. This study aimed to determine if environmental perceptions and place attachmen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b086744cba500c5aaf8b98fade000641
https://doi.org/10.5311/josis.2022.25.174
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6
The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function
Autor: William R. Critchley, Gina A. Smith, Ian C. Zachary, Michael A. Harrison, Sreenivasan Ponnambalam
Publikováno v: Journal of Cell Science. 136
Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that programs this receptor for trafficking and proteolysis, but the ubiquitin-modifying enzymes i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dca266e86b51edfb813aab4a8a943f6f
https://doi.org/10.1242/jcs.260657
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7
Exploring Determinants of HIV/AIDS Self-Testing Uptake in South Africa Using Generalised Linear Poisson and Geographically Weighted Poisson Regression
Autor: Emmanuel Fundisi, Simangele Dlamini, Tholang Mokhele, Gina Weir-Smith, Enathi Motolwana
Publikováno v: Healthcare; Volume 11; Issue 6; Pages: 881
Increased HIV/AIDS testing is of paramount importance in controlling the HIV/AIDS pandemic and subsequently saving lives. Despite progress in HIV/AIDS testing programmes, most people are still reluctant to test and thus are still unaware of their sta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e31ba381f65de0f9dfe0c5a976a7cb
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10
Factors Affecting Access to Public Healthcare Facilities in the City of Tshwane, South Africa
Autor: Thabiso Moeti, Tholang Mokhele, Gina Weir-Smith, Simangele Dlamini, Solomon Tesfamicheal
Publikováno v: International Journal of Environmental Research and Public Health
Volume 20
Issue 4
Pages: 3651
Access to healthcare services is largely determined by socioeconomic factors, with economically well-off individuals obtaining healthcare services more efficiently than those who are disadvantaged. This paper aims to assess the effects of socioeconom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6660cf13eda43f44fbfbc5cbceffa901
https://doi.org/10.3390/ijerph20043651
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