Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gina, Marka"'
Autor:
Sara Montserrat-Vazquez, Noelle J. Ali, Francesca Matteini, Javier Lozano, Tu Zhaowei, Eva Mejia-Ramirez, Gina Marka, Angelika Vollmer, Karin Soller, Mehmet Sacma, Vadim Sakk, Loris Mularoni, Jan Philipp Mallm, Mireya Plass, Yi Zheng, Hartmut Geiger, M. Carolina Florian
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-17 (2022)
Abstract One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking. He
Externí odkaz:
https://doaj.org/article/a4bb8c5a146d41029eb29433f0022be5
Autor:
Ani Grigoryan, Novella Guidi, Katharina Senger, Thomas Liehr, Karin Soller, Gina Marka, Angelika Vollmer, Yolanda Markaki, Heinrich Leonhardt, Christian Buske, Daniel B. Lipka, Christoph Plass, Yi Zheng, Medhanie A. Mulaw, Hartmut Geiger, Maria Carolina Florian
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-21 (2018)
Abstract Background The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show changes to their epigenome, such as alterations in DNA methylation and hi
Externí odkaz:
https://doaj.org/article/d09855951acf45d1acdccc0a55836829
Autor:
M Carolina Florian, Markus Klose, Mehmet Sacma, Jelena Jablanovic, Luke Knudson, Kalpana J Nattamai, Gina Marka, Angelika Vollmer, Karin Soller, Vadim Sakk, Nina Cabezas-Wallscheid, Yi Zheng, Medhanie A Mulaw, Ingmar Glauche, Hartmut Geiger
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2003389 (2018)
Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control prot
Externí odkaz:
https://doaj.org/article/edd84f3477ed491c831b529cfab0e5ea
Autor:
Mehmet, Saçma, Francesca, Matteini, Medhanie A, Mulaw, Ali, Hageb, Ruzhica, Bogeska, Vadim, Sakk, Angelika, Vollmer, Gina, Marka, Karin, Soller, Michael D, Milsom, Maria Carolina, Florian, Hartmut, Geiger
Publikováno v:
STAR protocols. 3(3)
Quantitative 3D imaging of organ-wide cellular and subcellular components is central for revealing and understanding complex interactions between stem cells and their microenvironment. Here, we present a gentle but fast whole-mount immunofluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c15b7039ee54c36cb8409e0ca8a73f6f
https://pubmed.ncbi.nlm.nih.gov/35769923
https://pubmed.ncbi.nlm.nih.gov/35769923
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Aging-associated leukemia and aging-associated immune remodeling are in part caused by aging of hematopoietic stem cells (HSCs). An increase in the activity of the small RhoGTPase cell division control protein 42 (Cdc42) within HSCs causes aging of H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7570496404892a8327e1019784c5f29
https://doi.org/10.1002/stem.3372
https://doi.org/10.1002/stem.3372
Autor:
Maria Carolina, Florian, Hanna, Leins, Michael, Gobs, Yang, Han, Gina, Marka, Karin, Soller, Angelika, Vollmer, Vadim, Sakk, Kalpana J, Nattamai, Ahmad, Rayes, Xueheng, Zhao, Kenneth, Setchell, Medhanie, Mulaw, Wolfgang, Wagner, Yi, Zheng, Hartmut, Geiger
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Aging cell 19(9), e13208 (2020). doi:10.1111/acel.13208
Aging Cell
Universidad de Barcelona
Aging cell 19(9), e13208 (2020). doi:10.1111/acel.13208
Aging Cell
Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain���of���activity mouse model presents with a premature agin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14529b9cae0e8e9b79cc6333c04b8040
Autor:
Francesca Matteini, Sara Montserrat-Vazquez, Noelle Ali, Javier Lozano, Tu Zhaowei, Eva Mejia-Ramirez de Arellano, Gina Marka, Angelika Vollmer, Karin Soller, Mehmet Saçma, Vadim Sakk, Loris Mularoni, Jan Phillip Mallm, Mireya Plass, Yi Zheng, Hartmut Geiger, Maria Carolina Florian
Publikováno v:
Experimental Hematology. 111:S49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31fa9e8d529b0bc3030e93858fcc2985
https://doi.org/10.1016/j.exphem.2022.07.066
https://doi.org/10.1016/j.exphem.2022.07.066
Autor:
Hartmut Geiger, Karin Soller, Daniel B. Lipka, Christoph Plass, Angelika Vollmer, Yi Zheng, Katharina Senger, Thomas Liehr, Medhanie A. Mulaw, Christian Buske, Heinrich Leonhardt, Ani Grigoryan, Gina Marka, Maria Carolina Florian, Yolanda Markaki, Novella Guidi
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-21 (2018)
Genome Biology
Genome Biology
Background The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show changes to their epigenome, such as alterations in DNA methylation and histone met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f43f32a9d2bbf79e36e2d0468e155a3
http://link.springer.com/article/10.1186/s13059-018-1557-3
http://link.springer.com/article/10.1186/s13059-018-1557-3
Autor:
Mehmet Sacma, Medhanie Mulaw, Ali Hageb, Ruzhica Bogeska, Vadim Sakk, Angelika Vollmer, Gina Marka, Karin Soller, Michael Milsom, Maria Florian, Hartmut Geiger
Publikováno v:
Experimental Hematology. 100:S58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc20df2e01d61965708daf061620a83b
https://doi.org/10.1016/j.exphem.2021.12.252
https://doi.org/10.1016/j.exphem.2021.12.252
Autor:
Karin Soller, Tanja Weil, Jose A. Cancelas, Novella Guidi, Johannes M. Weiss, Ludger Ständker, Gina Marka, Frank Kirchhoff, Hartmut Geiger, Karina Eiwen, Maria Carolina Florian, Mehmet Sacma
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal
Upon aging, hematopoietic stem cells (HSCs) undergo changes in function and structure, including skewing to myeloid lineages, lower reconstitution potential and loss of protein polarity. While stem cell intrinsic mechanisms are known to contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c6b80412477038cc8e3c62bc7c543b
http://europepmc.org/articles/PMC5376966
http://europepmc.org/articles/PMC5376966