Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Gin C. Hsieh"'
Autor:
Lei Shi, Madhavi Pai, David A. Degoey, Jerome F. Daanen, Gin C. Hsieh, Cenchen Zhan, Nayereh S Ghoreishi-Haack, Meagan M. Fricano, Jennifer M. Frost, Kort Michael E, Greta L. Lundgaard, Mark A. Matulenko, Torben R. Neelands, Odile F. El-Kouhen, Xu-Feng Zhang, Rebecca J. Gum
Publikováno v:
Journal of Medicinal Chemistry. 59:3373-3391
The genetic validation for the role of the Nav1.7 voltage-gated ion channel in pain signaling pathways makes it an appealing target for the potential development of new pain drugs. The utility of nonselective Nav blockers is often limited due to adve
Autor:
Jorge D. Brioni, Tracy L. Carr, Gin C. Hsieh, Madhavi Pai, Lawrence A. Black, Tiffany Runyan Garrison, Cenchen Zhan, Marlon D. Cowart, Erica Gomez, Gilbert Diaz, Arlene M. Manelli, Marina I. Strakhova, Anthony Lee, Jill M. Wetter
Publikováno v:
European Journal of Pharmacology. 684:87-94
Histamine H(3) receptor antagonists have been widely reported to improve performance in preclinical models of cognition, but more recently efficacy in pain models has also been described. Here, A-960656 ((R)-2-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)be
Autor:
B B Yao, William A. Carroll, Jennifer M. Frost, Madhavi Pai, George K. Grayson, Chang Zhu, Bradley A. Hooker, Alan S. Florjancic, Karin R. Tietje, Michael Meyer, Anthony V. Daza, Michael J. Dart, Tiffany Runyan Garrison, Derek W. Nelson, Keith B. Ryther, Gin C. Hsieh, Prasant Chandran, Odile F. El-Kouhen, Yihong Fan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2604-2608
SAR studies on a series of thiophene amide derivatives provided CB(2) receptor agonists. The activity of the compounds was characterized by radioligand binding determination, multiple functional assays, ADME, and pharmacokinetic studies. A representa
Autor:
Michael J. Dart, Cenchen Zhan, Anita K. Salyers, Erica J. Wensink, Gin C. Hsieh, Chang Z. Zhu, Michael Meyer, Prisca Honore, Madhavi Pai, B B Yao, Prasant Chandran, Bradley A. Hooker, William A. Carroll
Publikováno v:
British Journal of Pharmacology. 162:428-440
BACKGROUND AND PURPOSE Cannabinoid CB2 receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of inflammatory and neuropathic pain. However, mechanisms underlying CB2-mediated analgesic effects rem
Autor:
Arthur A. Hancock, Jill M. Wetter, Kennan C. Marsh, Prisca Honore, Gin C. Hsieh, Anita K. Salyers, Prasant Chandran, Timothy A. Esbenshade, Marlon D. Cowart, Joe Mikusa, Jorge D. Brioni, Erica J. Wensink, Madhavi Pai, Thomas R. Miller, Scott J. Baker, Chang Z. Zhu, David G. Witte
Publikováno v:
Pharmacology Biochemistry and Behavior. 95:41-50
The histamine H(4) receptor (H(4)R) is expressed primarily on cells involved in inflammation and immune responses. To determine the potential role of H(4)R in pain transmission, the effects of JNJ7777120, a potent and selective H(4) antagonist, were
Autor:
Prisca Honore, Chang Z. Zhu, Joseph P. Mikusa, PR Hollingsworth, B B Yao, Michael J. Dart, Prasant Chandran, Y Fan, Madhavi Pai, Meyer, Anthony V. Daza, Michael W. Decker, Gin C. Hsieh
Publikováno v:
British Journal of Pharmacology. 157:645-655
Background and purpose: Activation of cannabinoid (CB) receptors decreases nociceptive transmission in inflammatory or neuropathic pain states. However, the effects of CB receptor agonists in post-operative pain remain to be investigated. Here, we ch
Autor:
Robert S. Bitner, Arlene M. Manelli, Marina I. Strakhova, Jorge D. Brioni, Gin C. Hsieh, Timothy A. Esbenshade, Arthur L. Nikkel
Publikováno v:
Brain Research. 1250:41-48
Existing data on the expression of H(4) histamine receptor in the CNS are conflicting and inconclusive. In this report, we present the results of experiments that were conducted in order to elucidate H(4) receptor expression and localization in the b
Autor:
Vincent P. Hradil, Ann Tovcimak, Anita K. Salyers, Keith B. Ryther, Betty B. Yao, Prisca Honore, Tiffany Runyan Garrison, Bradley A. Hooker, Odile F. El Kouhen, Anthony V. Daza, Gin C. Hsieh, Yihong Fan, Erica J. Wensink, Michael Meyer, Megan E. Gallagher, Gerard B. Fox, Michael J. Dart, Chang Z. Zhu, Madhavi Pai, Chih-Liang Chin, Prasant Chandran, George K. Grayson, Chengmin Zhong
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:141-151
Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB(2) receptor activation have been largely derived from the use of receptor-selective ligands. Here, we report the identification of A-836339 [2,2,3,3-tetramethyl-cy
Autor:
Anthony V. Daza, Odile F. El-Kouhen, B B Yao, Prasant Chandran, Lanlan Li, Madhavi Pai, Gin C. Hsieh, Karin R. Tietje, Michael Meyer, Michael J. Dart, Chang Z. Zhu, George K. Grayson, Tiffany Runyan Garrison, Loan N. Miller, Jennifer M. Frost
Publikováno v:
Journal of Medicinal Chemistry. 51:1904-1912
A series of potent indol-3-yl-tetramethylcyclopropyl ketones have been prepared as CB 2 cannabinoid receptor ligands. Two unsubstituted indoles ( 5, 32) were the starting points for an investigation of the effect of indole ring substitutions on CB 2
Autor:
Prisca Honore, Anthony V. Daza, Michael J. Dart, Jennifer M. Frost, Y Fan, Tiffany Runyan Garrison, Anita K. Salyers, Prasant Chandran, B B Yao, Erica J. Wensink, James P. Sullivan, George K. Grayson, Madhavi Pai, Gin C. Hsieh, Michael Meyer, Chang Z. Zhu
Publikováno v:
British Journal of Pharmacology. 153:390-401
Background and purpose: Selective cannabinoid CB2 receptor agonists have demonstrated analgesic activity across multiple preclinical pain models. AM1241 is an indole derivative that exhibits high affinity and selectivity for the CB2 binding site and