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of 8
pro vyhledávání: '"Gily Schneider-Nachum"'
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Autor:
Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Celia A Schiffer, Stephanie A Moquin, Dustin Dovala, Daniel NA Bolon
Publikováno v:
eLife, Vol 11 (2022)
With the continual evolution of new strains of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that are more virulent, transmissible, and able to evade current vaccines, there is an urgent need for effective anti-viral drugs. The SARS-Co
Externí odkaz:
https://doaj.org/article/1d6d9ed5a9a3431a897dfc2f4cfe6b4b
Autor:
Julia M. Flynn, Qiu Yu J. Huang, Sarah N. Zvornicanin, Gily Schneider-Nachum, Ala M. Shaqra, Nese Kurt Yilmaz, Stephanie A. Moquin, Dustin Dovala, Celia A. Schiffer, Daniel N.A. Bolon
Drugs that target the main protease (Mpro) of SARS-CoV-2 are effective therapeutics that have entered clinical use. Wide-scale use of these drugs will apply selection pressure for the evolution of resistance mutations. To understand resistance potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7711be1bb8dfcd376640c160705a31c0
https://doi.org/10.1101/2023.03.02.530652
https://doi.org/10.1101/2023.03.02.530652
Publikováno v:
Current opinion in structural biology. 78
Robust technology has been developed to systematically quantify fitness landscapes that provide valuable opportunities to improve our understanding of drug resistance and define new avenues to develop drugs with reduced resistance susceptibility. We
Autor:
Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Celia A Schiffer, Stephanie A Moquin, Dustin Dovala, Daniel NA Bolon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1623ed609f1f7a16a3f9bdbef949f996
https://doi.org/10.7554/elife.77433.sa2
https://doi.org/10.7554/elife.77433.sa2
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Autor:
Julia M. Flynn, Neha Samant, Gily Schneider-Nachum, David T. Barkan, Nese Kurt Yilmaz, Celia A. Schiffer, Stephanie A. Moquin, Dustin Dovala, Daniel N.A. Bolon
With the continual evolution of new strains of SARS-CoV-2 that are more virulent, transmissible, and able to evade current vaccines, there is an urgent need for effective anti-viral drugs. SARS-CoV-2 main protease (Mpro) is a leading target for drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a93a1c1dca91581037672ab47ce9365
https://doi.org/10.1101/2022.01.26.477860
https://doi.org/10.1101/2022.01.26.477860
Publikováno v:
Virus evolution. 7(2)
Investigating the relationships between protein function and fitness provides keys for understanding biochemical mechanisms that underly evolution. Mutations with partial fitness defects can delineate the threshold of biochemical function required fo
Publikováno v:
Virus Evolution; Dec2021, Vol. 7 Issue 2, p1-10, 10p
Publikováno v:
Drug Week; 3/10/2023, p2407-2407, 1p