C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis.

Autor: Xu X; Chemotaxis Signaling Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States., Pots H; Department of Cell Biochemistry, University of Groningen, Groningen, Netherlands., Gilsbach BK; Functional Neuroproteomics and Translational Biomarkers in Neurodegenerative Diseases German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Parsons D; Chemotaxis Signaling Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States., Veltman DM; Department of Cell Biochemistry, University of Groningen, Groningen, Netherlands., Ramachandra SG; Chemotaxis Signaling Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States., Li H; Chemotaxis Signaling Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States., Kortholt A; Department of Cell Biochemistry, University of Groningen, Groningen, Netherlands., Jin T; Chemotaxis Signaling Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Nov 29; Vol. 13, pp. 1075386. Date of Electronic Publication: 2022 Nov 29 (Print Publication: 2022).

Regulation of LRRK2: insights from structural and biochemical analysis.

Autor: Gilsbach BK; DZNE-German Center for Neurodegenerative Diseases, Otfried-Müller Str. 23, D-72076 Tübingen, Germany., Eckert M; DZNE-German Center for Neurodegenerative Diseases, Otfried-Müller Str. 23, D-72076 Tübingen, Germany., Gloeckner CJ; DZNE-German Center for Neurodegenerative Diseases, Otfried-Müller Str. 23, D-72076 Tübingen, Germany.; University of Tübingen, Institute for Ophthalmic Research, Center for Ophthalmology, Elfriede-Aulhorn-Str. 7, D-72076 Tübingen, Germany.

Publikováno v: Biological chemistry [Biol Chem] 2018 Jun 27; Vol. 399 (7), pp. 637-642.

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.

Autor: Guaitoli G; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;, Raimondi F; Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy; Cell Networks, University of Heidelberg, 69120 Heidelberg, Germany;, Gilsbach BK; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Department of Cell Biochemistry, University of Groningen, Groningen 9747 AG, The Netherlands; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227 Dortmund, Germany;, Gómez-Llorente Y; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Deyaert E; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; Vlaams Instituut voor Biotechnologie, Structural Biology Research Center, Vrije Universiteit Brussel, 1050 Brussels, Belgium;, Renzi F; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Li X; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Schaffner A; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Jagtap PK; Center for Integrated Protein Science Munich at Department of Chemistry, Technische Universität München, 85747 Garching, Germany; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Munich, Germany;, Boldt K; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;, von Zweydorf F; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;, Gotthardt K; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227 Dortmund, Germany;, Lorimer DD; Beryllium Discovery Corporation, Bainbridge Island, WA 98110;, Yue Z; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Burgin A; Broad Institute, Cambridge, MA 02142;, Janjic N; SomaLogic, Boulder, CO 80301., Sattler M; Center for Integrated Protein Science Munich at Department of Chemistry, Technische Universität München, 85747 Garching, Germany; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Munich, Germany;, Versées W; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; Vlaams Instituut voor Biotechnologie, Structural Biology Research Center, Vrije Universiteit Brussel, 1050 Brussels, Belgium;, Ueffing M; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;, Ubarretxena-Belandia I; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de., Kortholt A; Department of Cell Biochemistry, University of Groningen, Groningen 9747 AG, The Netherlands; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de., Gloeckner CJ; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Jul 26; Vol. 113 (30), pp. E4357-66. Date of Electronic Publication: 2016 Jun 29.

Structural Characterization of LRRK2 Inhibitors.

Autor: Gilsbach BK; †Department of Cell Biochemistry, University of Groningen, 9747AG Groningen, The Netherlands., Messias AC; ‡Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.; §Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching bei München, Germany., Ito G; ∥University of Dundee, DD1 4HN Dundee, Scotland., Sattler M; ‡Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.; §Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching bei München, Germany., Alessi DR; ∥University of Dundee, DD1 4HN Dundee, Scotland., Wittinghofer A; ⊥Max-Planck Institut für Molekulare Physiologie, 44202 Dortmund, Germany., Kortholt A; †Department of Cell Biochemistry, University of Groningen, 9747AG Groningen, The Netherlands.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 May 14; Vol. 58 (9), pp. 3751-6. Date of Electronic Publication: 2015 May 01.

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.

Autor: Gilsbach BK; Department of Cell Biochemistry, University of Groningen Groningen, Netherlands., Kortholt A; Department of Cell Biochemistry, University of Groningen Groningen, Netherlands.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2014 May 05; Vol. 7, pp. 32. Date of Electronic Publication: 2014 May 05 (Print Publication: 2014).