Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gils Roex"'
Autor:
Astrid Van den Eynde, Laura Gehrcken, Tias Verhezen, Ho Wa Lau, Christophe Hermans, Hilde Lambrechts, Tal Flieswasser, Delphine Quatannens, Gils Roex, Karen Zwaenepoel, Elly Marcq, Philippe Joye, Edgar Cardenas De La Hoz, Christophe Deben, Alessia Gasparini, Pierre Montay-Gruel, Maxim Le Compte, Eva Lion, Filip Lardon, Steven Van Laere, Vasiliki Siozopoulou, Diana Campillo-Davo, Jorrit De Waele, Patrick Pauwels, Julie Jacobs, Evelien Smits, Jonas R. M. Van Audenaerde
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background It remains challenging to obtain positive outcomes with chimeric antigen receptor (CAR)-engineered cell therapies in solid malignancies, like colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). A major obstacle is
Externí odkaz:
https://doaj.org/article/8761eb0063d942beb968b458b3b522ca
Autor:
Donovan Flumens, Diana Campillo-Davo, Ibo Janssens, Gils Roex, Jorrit De Waele, Sébastien Anguille, Eva Lion
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102112- (2023)
Summary: To avoid mispairing between native and introduced T cell receptors (TCRs) and to prevent graft-versus-host disease in allogeneic T cell therapies, TCRα and TCRβ chains of native TCRs are knocked out via CRISPR-Cas9. We demonstrate the isol
Externí odkaz:
https://doaj.org/article/80548a7f7c2441c1b89199b1e11e0f9c
Autor:
Gils Roex, Diana Campillo-Davo, Donovan Flumens, Philip Anthony Gilbert Shaw, Laurens Krekelbergh, Hans De Reu, Zwi N. Berneman, Eva Lion, Sébastien Anguille
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy has proven to be a valuable new treatment option for patients with B-cell malignancies. However, by applying selective pressure, outgrowth of antigen-negative tumor cells can occur, e
Externí odkaz:
https://doaj.org/article/05c1c30b2722445782796239a7b077f8
Autor:
Gils Roex, Marijke Timmers, Kristien Wouters, Diana Campillo-Davo, Donovan Flumens, Wilfried Schroyens, Yiwei Chu, Zwi N. Berneman, Eva Lion, Feifei Luo, Sébastien Anguille
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2020)
Abstract Background B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T-cell therapy is an emerging treatment option for multiple myeloma. The aim of this systematic review and meta-analysis was to determine its safety and cli
Externí odkaz:
https://doaj.org/article/c5abce8e1fbc403397769e67dc74eb91
Autor:
Diana Campillo-Davo, Maxime De Laere, Gils Roex, Maarten Versteven, Donovan Flumens, Zwi N. Berneman, Viggo F. I. Van Tendeloo, Sébastien Anguille, Eva Lion
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 396 (2021)
Messenger RNA (mRNA) electroporation is a powerful tool for transient genetic modification of cells. This non-viral method of genetic engineering has been widely used in immunotherapy. Electroporation allows fine-tuning of transfection protocols for
Externí odkaz:
https://doaj.org/article/54fd5dcca621443087718cd1a5b2ab14
Autor:
Marijke Timmers, Gils Roex, Yuedi Wang, Diana Campillo-Davo, Viggo F. I. Van Tendeloo, Yiwei Chu, Zwi N. Berneman, Feifei Luo, Heleen H. Van Acker, Sébastien Anguille
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Chimeric antigen receptor (CAR)-modified T cell therapy is a rapidly emerging immunotherapeutic approach that is revolutionizing cancer treatment. The impressive clinical results obtained with CAR-T cell therapy in patients with acute lymphoblastic l
Externí odkaz:
https://doaj.org/article/49a4a6c44b2845dd97520781fda0d3e9
Autor:
Gils Roex, Tom Feys, Yves Beguin, Tessa Kerre, Xavier Poiré, Philippe Lewalle, Peter Vandenberghe, Dominique Bron, Sébastien Anguille
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 194 (2020)
Chimeric antigen receptor (CAR)-T-cell therapy is an innovative form of adoptive cell therapy that has revolutionized the treatment of certain hematological malignancies, including B-cell non-Hodgkin lymphoma (NHL) and B-cell acute lymphoblastic leuk
Externí odkaz:
https://doaj.org/article/86efcb9c5e2f4835884c8341b7c9f981
Autor:
Diana Campillo-Davo, Maarten Versteven, Gils Roex, Hans De Reu, Sanne van der Heijden, Sébastien Anguille, Zwi N. Berneman, Viggo F. I. Van Tendeloo, Eva Lion
Publikováno v:
Cancers, Vol 12, Iss 2, p 256 (2020)
The functional avidity of T-cell receptor (TCR)-engineered T cells towards their cognate epitope plays a crucial role in successfully targeting and killing tumor cells expressing the tumor-associated antigen (TAA). When evaluating in vitro functional
Externí odkaz:
https://doaj.org/article/271a42582cf24398a48731df8ad4d1da
Autor:
Heleen H. Van Acker, Maarten Versteven, Felix S. Lichtenegger, Gils Roex, Diana Campillo-Davo, Eva Lion, Marion Subklewe, Viggo F. Van Tendeloo, Zwi N. Berneman, Sébastien Anguille
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 5, p 579 (2019)
Acute myeloid leukemia (AML) is a type of blood cancer characterized by the uncontrolled clonal proliferation of myeloid hematopoietic progenitor cells in the bone marrow. The outcome of AML is poor, with five-year overall survival rates of less than
Externí odkaz:
https://doaj.org/article/7c3d9ad90d30417facb4b8cb2ae2e404
Autor:
Yuedi Wang, Yiyuan Gao, Congyi Niu, Bo Wang, Shushu Zhao, Gils Roex, Jiawen Qian, Jingbo Qie, Lin Chen, Chenhe Yi, Sébastien Anguille, Jie Liu, Feifei Luo, Yiwei Chu
Publikováno v:
Cancer immunology and immunotherapy
Chimeric antigen receptor (CAR) T-cell therapy achieves great success for hematological malignancies. However, clinical trials have revealed some limitations in both improving the efficacy and reducing the relapse, which calls for innovative strategi