Isolation and characterization of human embryonic stem cell-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profiles

Autor: Pezhouman, Arash, Engel, James L, Nguyen, Ngoc B, Skelton, Rhys JP, Gilmore, William Blake, Qiao, Rong, Sahoo, Debashis, Zhao, Peng, Elliott, David A, Ardehali, Reza

Publikováno v: Cardiovascular research, vol 118, iss 3

AimsWe prospectively isolate and characterize first and second heart field- and nodal-like cardiomyocytes using a double reporter line from human embryonic stem cells. Our double reporter line utilizes two important transcription factors in cardiac d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::55a568c013b2978fb702db80e457769a
https://escholarship.org/uc/item/5947n3wb

Isolation and characterization of human embryonic stem cell-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profiles.

Autor: Pezhouman A; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA., Engel JL; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA., Nguyen NB; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA.; Molecular, Cellular and Integrative Physiology Graduate Program, University of California, Los Angeles, CA 90095, USA., Skelton RJP; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA., Gilmore WB; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA., Qiao R; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA., Sahoo D; Departments of Pediatrics and Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA., Zhao P; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA., Elliott DA; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC 3052, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, VIC 3052, Australia., Ardehali R; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA.; Molecular, Cellular and Integrative Physiology Graduate Program, University of California, Los Angeles, CA 90095, USA.; Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2022 Feb 21; Vol. 118 (3), pp. 828-843.