A randomized clinical trial to evaluate the single-dose pharmacokinetics, pharmacodynamics, and safety of sitagliptin in pediatric patients with type 2 diabetes.

Autor: Fraser IP; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Neufeld ND; Neufeld Medical Group, West Hollywood, California., Fox LA; Department of Endocrinology and Diabetes, Nemours Children's Health System, Jacksonville, Florida., Kipnes MS; Diabetes and Glandular Disease Clinic, San Antonio, Texas., Miller TL; Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, Florida., Zeitler PS; Pediatric Endocrinology, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, Colorado., Rodriguez H; Pediatric Diabetes Clinical Program, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana., Gilmartin JH; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Lee SJ; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Patterson JK; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Li XS; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Maganti L; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Luo WL; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Tatosian DA; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Stoch SA; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey.

Publikováno v: Pediatric diabetes [Pediatr Diabetes] 2019 Feb; Vol. 20 (1), pp. 48-56. Date of Electronic Publication: 2018 Nov 13.