Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gilly Martin"'
Autor:
Joanna D. Davies, Sara E. Marshall, Stephen P. Cobbold, Jenny M. Phillips, Gilly Martin, Herman Waldmann
Publikováno v:
Transplantation. 62:1614-1621
The induction of tolerance in a primed immune system would be valuable therapeutically, but has been difficult to achieve. Mice primed to multiple minor histoincompatible antigens (minors) are able to rapidly reject secondary grafts using either thei
Publikováno v:
Scopus-Elsevier
Autor:
Els M. E. Verdegaal, Conny Hoogstraten, Cornelia S. McLean, Susanne Osanto, M. Leigh Shaw, Jayne Curry, Gilly Martin, Peter T. Loudon
Publikováno v:
The journal of gene medicine. 5(5)
Background DISC-hGMCSF is a gH-deleted HSV-2 based vector expressing human GM-CSF that has entered clinical trials for the therapy of metastatic melanoma. To determine whether this product also has potential to treat breast carcinoma, a series of in
Autor:
Jayne C. Miller, M. Leigh Shaw, Mike Boursnell, Debbie A. Day, Diane M. Blakeley, Richard C. Lowden, Cornelia S. McLean, Peter T. Loudon, Imogen A. Duncan, Gilly Martin
Publikováno v:
The journal of gene medicine. 3(5)
Background DISC-hGMCSF is a gH-deleted HSV-2 based vector expressing human GM-CSF that is being developed for cancer immunotherapy. To support first clinical use, a range of preclinical safety studies were performed using DISC-hGMCSF in addition to D
Autor:
Terry Ulrich, Stephen J. Thompson, Glen Leesman, Gilly Martin, Clare Varley, Alison Mann, Marie Davies, Stephen Thompson, Finn Holding, Maria J. Watts, Jonathan T Beech, Terry O'neill
Publikováno v:
Biochemical Society transactions. 25(2)
Publikováno v:
European journal of immunology. 20(12)
Mice given short courses of anti-CD4 and anti-CD8 monoclonal antibodies became tolerant of allogeneic skin grafted at the same time. Tolerance could be obtained without T cell depletion across multiple minor antigen mismatches, both in naive and prim
Publikováno v:
Transplantation. 42:239-247
One of the major complications of allogeneic bone marrow transplantation is graft-versus-host disease. This can be avoided by removing the mature T cells from the marrow, most conveniently by the use of monoclonal antibodies. However, T cell purging
Publikováno v:
Scopus-Elsevier
Allogeneic reactions are the major limitation to organ transplantation. These are manifested as rejection of the grafted tissue, and also, in the case of bone marrow transplantation (BMT), graft-versus-host disease (GVHD). Recent methods of avoiding