Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Gillis R. Otten"'
1
Akademický článek
Self-amplifying mRNA seasonal influenza vaccines elicit mouse neutralizing antibody and cell-mediated immunity and protect ferrets
Autor: Michael Cheung, Cheng Chang, Raveen Rathnasinghe, Evan Rossignol, Yunfei Zhang, Annette Ferrari, Harsh Patel, Yanjun Huang, Michelle Sanchez Guillen, Tina Scalzo, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Nedzad Music, Giuseppe Palladino, Yingxia Wen
Publikováno v: npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Currently licensed influenza vaccines focus immune responses on viral hemagglutinin (HA), while the other major surface glycoprotein neuraminidase (NA) is not tightly controlled in inactivated vaccine formulations despite evidence that anti-
Externí odkaz: https://doaj.org/article/34eefbdcbdca47e4b9effcc04a79f050
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2
Akademický článek
Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets
Autor: Cheng Chang, Nedzad Music, Michael Cheung, Evan Rossignol, Sukhmani Bedi, Harsh Patel, Mohammad Safari, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Giuseppe Palladino, Yingxia Wen
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 195-205 (2022)
Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins,
Externí odkaz: https://doaj.org/article/912ad34f33834057b76e58f148316bfd
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3
Akademický článek
Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models
Autor: Giuseppe Palladino, Cheng Chang, Changkeun Lee, Nedzad Music, Ivna De Souza, Jonathan Nolasco, Samuel Amoah, Pirada Suphaphiphat, Gillis R. Otten, Ethan C. Settembre, Yingxia Wen
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 225-235 (2022)
The spike (S) protein of SARS-CoV-2 plays a crucial role in cell entry, and the nucleocapsid (N) protein is highly conserved among human coronavirus homologs. For potentially broad effectiveness against both original virus and emerging variants, we d
Externí odkaz: https://doaj.org/article/f78df334f83d4554ba745ba254900e27
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5
Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models
Autor: Giuseppe Palladino, Cheng Chang, Changkeun Lee, Nedzad Music, Ivna De Souza, Jonathan Nolasco, Samuel Amoah, Pirada Suphaphiphat, Gillis R. Otten, Ethan C. Settembre, Yingxia Wen
Publikováno v: Molecular therapy. Methodsclinical development. 25
The spike (S) protein of SARS-CoV-2 plays a crucial role in cell entry, and the nucleocapsid (N) protein is highly conserved among human coronavirus homologs. For potentially broad effectiveness against both original virus and emerging variants, we d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986ee7ddc3b8c1156e256cd951a11a1a
https://pubmed.ncbi.nlm.nih.gov/35345593
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6
The Preparation and Physicochemical Characterization of Aluminum Hydroxide/TLR7a, a Novel Vaccine Adjuvant Comprising a Small Molecule Adsorbed to Aluminum Hydroxide
Autor: Elvira Ianni, Manmohan Singh, Marianna Aggravi, Casey Judge, Gillis R. Otten, Donatello Laera, Derek T. O'Hagan, Simone Bufali, Padma Malyala, Simona Cianetti
Publikováno v: Journal of Pharmaceutical Sciences. 107:1577-1585
Adjuvants are necessary to enable vaccine development against a significant number of challenging pathogens for which effective vaccines are not available. We engineered a novel small-molecule immune potentiator, a benzonaphthyridine agonist targetin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625fb816013b482783b36675d42c4fc2
https://doi.org/10.1016/j.xphs.2018.01.024
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7
Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design
Autor: Farid Sari-Sarraf, Gillis R. Otten, Timothy Pepini, Thomas Carsillo, Carlo Iavarone, Jeffrey B. Ulmer, Dong Yu, Alicia L. Carlson, Giulietta Maruggi, Jason C. Debasitis, Katrin Ramsauer, Anne-Marie Pulichino, Andrew Geall
Publikováno v: The Journal of Immunology. 198:4012-4024
RNA-based vaccines have recently emerged as a promising alternative to the use of DNA-based and viral vector vaccines, in part because of the potential to simplify how vaccines are made and facilitate a rapid response to newly emerging infections. SA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bb56454b7ca4b588da1373c4fa5482
https://doi.org/10.4049/jimmunol.1601877
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8
A phase 1, randomized, observer blind, antigen and adjuvant dosage finding clinical trial to evaluate the safety and immunogenicity of an adjuvanted, trivalent subunit influenza vaccine in adults ≥ 65 years of age
Autor: Gillis R. Otten, Vincent Matassa, Max Ciarlet, Brett Leav
Publikováno v: Vaccine. 38(3)
Objective To assess the safety and immunogenicity of the MF59®-adjuvanted trivalent influenza vaccine (aTIV; Fluad®) compared with modified aTIV formulations. Methods A total of 196 subjects ≥ 65 years were randomized to receive 7 different formu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6098060c511127f2d100fb2e6ffb275
https://pubmed.ncbi.nlm.nih.gov/31679865
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9
Stable Nanoemulsions for the Delivery of Small Molecule Immune Potentiators
Autor: Andrew T. Miller, Tom Y.-H. Wu, Luis Brito, Manmohan Singh, Derek T. O'Hagan, Rushit N. Lodaya, Gillis R. Otten
Publikováno v: Journal of pharmaceutical sciences. 107(9)
Adjuvants are required to enhance immune responses to typically poorly immunogenic recombinant antigens. Toll-like receptor agonists (TLRa) have been widely evaluated as adjuvants because they activate the innate immune system. Currently, licensed va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c92e8d954152711cd863a47e9a2f472
https://pubmed.ncbi.nlm.nih.gov/29883663
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10
The Development of Self-Emulsifying Oil-in-Water Emulsion Adjuvant and an Evaluation of the Impact of Droplet Size on Performance
Autor: Derek T. O'Hagan, Stephanie Kay Dodd, Mildred Ugozzoli, Mansoor M. Amiji, Ruchi Rudraprasad Shah, Mary Schaefer, Gillis R. Otten, Luis Brito, Manmohan Singh
Publikováno v: Journal of Pharmaceutical Sciences. 104:1352-1361
Microfluidization is an established technique for preparing emulsion adjuvant formulations for use in vaccines. Although this technique reproducibly yields high-quality stable emulsions, it is complex, expensive, and requires proprietary equipment. F
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce28b41c36869e663db19000354d0754
https://doi.org/10.1002/jps.24337
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