Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trialsResearch in context

Autor: Soumi Gupta, Kelly Lau, Cary O. Harding, Gillian Shepherd, Ryan Boyer, John P. Atkinson, Vijaya Knight, Joy Olbertz, Kevin Larimore, Zhonghu Gu, Mingjin Li, Orli Rosen, Stephen J. Zoog, Haoling H. Weng, Becky Schweighardt

Publikováno v: EBioMedicine, Vol 37, Iss , Pp 366-373 (2018)

Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safe

Externí odkaz: https://doaj.org/article/35d18890af2c449283e0ae76ff18ae3e

Children, death and society in Late Bronze Age and Iron Age Sicily

Autor: Gillian Shepherd

Publikováno v: Children in Antiquity ISBN: 9781315542812

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cdfa8d7f18a53e2b7d66309a5ef5fe1
https://doi.org/10.4324/9781315542812-37

Critical analysis of the utility of initial pleural aspiration in the diagnosis and management of suspected malignant pleural effusion

Autor: David J. McCracken, Rebecca Varatharajah, Alexandra Dudina, Eihab O Bedawi, Stamatoula Tsikrika, Radhika Banka, Rachel M. Mercer, Robert J. Hallifax, Janis K. Shute, Dinesh Addala, Maged Hassan, Rachelle Asciak, Gillian Shepherd, Qiang Lu, Olalla Castro-Añón, Vineeth George, Najib M. Rahman

Publikováno v: BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
Mercer, R M, Varatharajah, R, Shepherd, G, Lu, Q, Castro-añón, O, Mccracken, D J, Dudina, A, Addala, D, Tsikrika, S, George, V, Banka, R, Asciak, R, Hassan, M, Hallifax, R, Bedawi, E O, Shute, J K & Rahman, N M 2020, ' Critical analysis of the utility of initial pleural aspiration in the diagnosis and management of suspected malignant pleural effusion ', BMJ Open Respiratory Research, vol. 7, no. 1, e000701 . https://doi.org/10.1136/bmjresp-2020-000701
BMJ Open Respiratory Research

IntroductionCurrent guidelines recommend an initial pleural aspiration in the investigation and management of suspected malignant pleural effusions (MPEs) with the aim of establishing a diagnosis, identifying non-expansile lung (NEL) and, at times, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412c2ab330225085fb56b09322f148f1
https://bmjopenrespres.bmj.com/content/7/1/e000701.full

Negative predictive value of pleural fluid cytology in patients with a background of cancer

Autor: Maged Hassan, Rachelle Asciak, Robert J. Hallifax, Qianj Lu, Alexandra Dudina, Andrew Thayanandan, Gillian Shepherd, Olalla Castro Añon, Rebecca Varatharajah, Eihab O Bedawi, Najib M. Rahman, John M. Wrightson, David J. McCracken, Rachel M. Mercer, Mata Tsikrika

Publikováno v: Pleural and mediastinal malignancies.

Background: The diagnostic yield for malignancy of pleural fluid (PF) cytology in patients with pleural effusion (PE) is well known but there is scarce data in the setting of patients who developed a PE and have a prior diagnosis of cancer. Aim: The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9959e0164ed8818e816048ad48c25dce
https://doi.org/10.1183/13993003.congress-2019.oa494

How often is a single therapeutic aspiration sufficient to manage a malignant pleural effusion and does oncological treatment have an impact on this?

Autor: Najib M. Rahman, Rachel M. Mercer, Gillian Shepherd

Publikováno v: Pleural and mediastinal malignancies.

Introduction: Patients with a malignant pleural effusion (MPE) usually require a definitive intervention to prevent fluid reaccumulation after an initial therapeutic aspiration, often in the form of chest drain and pleurodesis or indwelling pleural c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd738c6fa04511b0fd729c19a957a25c
https://doi.org/10.1183/13993003.congress-2019.pa3096