Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gillian Paine"'
Autor:
Jonathan H. Schatz, Eli Chapman, Abimael D. Rodríguez, Graham Packham, Cyril H. Benes, Francisco Vega, Patricia Greninger, Gillian Paine-Murrieta, Andrew J. Ambrose, Christopher J. Zerio, Praechompoo Pongtornpipat, Amit D. Amin, Lingxiao Li, Luis A. Amador, Carlos Jiménez-Romero, Elizabeth Lemm, Sarah Wilmore, Alison M. Yeomans, Joseph Tillotson, Tara L. Peters
Figure S1. Elatol was submitted to a 96-member kinome screen to evaluate specificity. Figure S2. A) Michaelis-Menten curves of eIF4A1 wild type (blue), K82R (red), and K238E (green). Michaelis- Menten constants for eIF4A1 wild type and mutants in tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b0c08aa1ad75e37b8b895a22244a71
https://doi.org/10.1158/1078-0432.22469778.v1
https://doi.org/10.1158/1078-0432.22469778.v1
Autor:
Jonathan H. Schatz, Eli Chapman, Abimael D. Rodríguez, Graham Packham, Cyril H. Benes, Francisco Vega, Patricia Greninger, Gillian Paine-Murrieta, Andrew J. Ambrose, Christopher J. Zerio, Praechompoo Pongtornpipat, Amit D. Amin, Lingxiao Li, Luis A. Amador, Carlos Jiménez-Romero, Elizabeth Lemm, Sarah Wilmore, Alison M. Yeomans, Joseph Tillotson, Tara L. Peters
Purpose: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of cap-dependent translation initiation and is a well-established target for cancer therapy, but no drug against it has entered evaluation in patients. We identified and cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0a4100a7388fdcb4d088138f676666
https://doi.org/10.1158/1078-0432.c.6527340
https://doi.org/10.1158/1078-0432.c.6527340
Autor:
Carlos Jiménez-Romero, Gillian Paine-Murrieta, Patricia Greninger, Elizabeth Lemm, Praechompoo Pongtornpipat, Lingxiao Li, Graham Packham, Cyril H. Benes, Abimael D. Rodríguez, Amit Dipak Amin, Luis A. Amador, Joseph Tillotson, Alison Yeomans, Christopher J. Zerio, Sarah Wilmore, Tara L. Peters, Andrew J. Ambrose, Eli Chapman, Francisco Vega, Jonathan H. Schatz
Purpose: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of cap-dependent translation initiation and is a well-established target for cancer therapy, but no drug against it has entered evaluation in patients. We identified and cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f6f6b9b23765b0975754b23eaefc9b
https://eprints.soton.ac.uk/423285/
https://eprints.soton.ac.uk/423285/
Autor:
Richard M. Kris, A. A. Leslie Gunatilaka, Nathan Grunow, Ya Ming Xu, Gillian Paine-Murrieta, E. M. Kithsiri Wijeratne, Stephen Felder, Manping X. Liu
Publikováno v:
Journal of medicinal chemistry. 58(17)
Prostate cancer (PC) is the second most prevalent cancer among men in Western societies, and those who develop metastatic castration-resistant PC (CRPC) invariably succumb to the disease. The need for effective treatments for CRPC is a pressing conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b267f8a714002d8471534f4018c3e4
https://pubmed.ncbi.nlm.nih.gov/26305181
https://pubmed.ncbi.nlm.nih.gov/26305181
Autor:
Eric Swain, Margaret Loftus, Marek Skacel, James Pettay, Thomas M. Grogan, Raymond R. Tubbs, James R. Cook, Gillian Paine, Patrick C. Roche, Todd S. Barry
Publikováno v:
Journal of Molecular Histology. 38:159-165
Implementation of interphase fluorescence in situ hybridization (FISH) assays in the clinical laboratory requires validation against established methods. Validation tools in common use include exchange of consecutive sections with another institution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c679cc233db7ed4ebdb90f04105c444
https://doi.org/10.1007/s10735-006-9066-1
https://doi.org/10.1007/s10735-006-9066-1
Autor:
Nathan T, Ihle, Ryan, Williams, Sherry, Chow, Wade, Chew, Margareta I, Berggren, Gillian, Paine-Murrieta, Daniel J, Minion, Robert J, Halter, Peter, Wipf, Robert, Abraham, Lynn, Kirkpatrick, Garth, Powis
Publikováno v:
Molecular Cancer Therapeutics. 3:763-772
We have developed biologically stable semisynthetic viridins as inhibitors of phosphoinositide (PtdIns)-3-kinases. The most active compound was PX-866 (acetic acid (1S,4E,10R,11R,13S,14R)-[4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0644e177d8a9bb9db0b7d91e09e893f0
https://doi.org/10.1158/1535-7163.763.3.7
https://doi.org/10.1158/1535-7163.763.3.7
Publikováno v:
Molecular Cancer Therapeutics. 3:233-244
The hypoxia-inducible factor-1 (HIF-1) transcription factor is an important regulator of tumor response to hypoxia that include increased angiogenesis, glycolytic metabolism, and resistance to apoptosis. HIF-1 activity is regulated by the availabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a52d39b8ad341a5dfa9759507f9d3d23
https://doi.org/10.1158/1535-7163.233.3.3
https://doi.org/10.1158/1535-7163.233.3.3
Autor:
Zaver M. Bhujwalla, Denise J. Roe, Robert J. Gillies, Brenda Baggett, X He, Charles W. Taylor, R van Sluis, Natarajan Raghunand, Gillian Paine-Murrieta, Brent P. Mahoney
Publikováno v:
British Journal of Cancer
The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidic compared to normal tissues. In-vitro, low pH reduces the uptake of weakly basic chemotherapeutic drugs and, hence, reduces their cytotoxicity. This phenomenon has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8efc6a025e8af2789a520e1913662dc
https://doi.org/10.1038/sj.bjc.6690455
https://doi.org/10.1038/sj.bjc.6690455
Autor:
Robert T. Dorr, Evan M. Hersh, Cynthia S. Johnson, Rebecca A. Curtis, Charles W. Taylor, Carole Y. Funk, Gillian Paine-Murrieta, FH Thompson, Marialouisa H. A. Lopez
Publikováno v:
Cancer Chemotherapy and Pharmacology. 40:209-214
Purpose: To test a number of established human tumor cell lines and early passage breast cancer (UACC2150) and melanoma cells (UACC1273) for growth in the scid mouse and the tumors' response to conventional chemotherapeutic drugs. Methods: Establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d2d9daee692db4b7d31ce21de70274
https://doi.org/10.1007/s002800050648
https://doi.org/10.1007/s002800050648
Publikováno v:
Molecular cancer therapeutics. 3(3)
The hypoxia-inducible factor-1 (HIF-1) transcription factor is an important regulator of tumor response to hypoxia that include increased angiogenesis, glycolytic metabolism, and resistance to apoptosis. HIF-1 activity is regulated by the availabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c25c65d7e9af607b3e07e00676cc0e1
https://pubmed.ncbi.nlm.nih.gov/15026544
https://pubmed.ncbi.nlm.nih.gov/15026544