Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gillian Morrison"'
Autor:
Sara Badodi, Nicola Pomella, Xinyu Zhang, Gabriel Rosser, John Whittingham, Maria Victoria Niklison-Chirou, Yau Mun Lim, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Christopher D. Bennett, Steven C. Clifford, Andrew Peet, M. Albert Basson, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
BMI1 and CHD7 are chromatin remodelling genes with a role in medulloblastoma pathogenesis. Here, the authors demonstrate that the BMI1High/CHD7Low signature mediates metabolic adaptation in G4 MB and predicts response to inositol treatment either alo
Externí odkaz:
https://doaj.org/article/e099abd2067e489ba7b766a7107a8238
Autor:
Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Glioma stem cells (GSCs) retain the ability to partially differentiate, but it is unclear how the brain microenvironment may influence this response. Here the authors show that glioblastoma cells infiltrating into the white matter acquire pre-oligode
Externí odkaz:
https://doaj.org/article/1dfd4c8671124520ac4d6ba779864aae
Autor:
Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c6f6fdd59beb4ad2afd4c54046152174
Autor:
Pooran Singh Dewari, Benjamin Southgate, Katrina Mccarten, German Monogarov, Eoghan O'Duibhir, Niall Quinn, Ashley Tyrer, Marie-Christin Leitner, Colin Plumb, Maria Kalantzaki, Carla Blin, Rebecca Finch, Raul Bardini Bressan, Gillian Morrison, Ashley M Jacobi, Mark A Behlke, Alex von Kriegsheim, Simon Tomlinson, Jeroen Krijgsveld, Steven M Pollard
Publikováno v:
eLife, Vol 7 (2018)
CRISPR/Cas9 can be used for precise genetic knock-in of epitope tags into endogenous genes, simplifying experimental analysis of protein function. However, Cas9-assisted epitope tagging in primary mammalian cell cultures is often inefficient and reli
Externí odkaz:
https://doaj.org/article/75965eb632694dcb913174d34eba59b9
Autor:
Jemima J. Burden, Lucy Brooks, Zane Jaunmuktane, Daniela Kocher, Simona Parrinello, Megan Woodberry, Luca Richards, Leila Zakka, Steven M. Pollard, Sebastian Brandner, Melanie Clements, Peter B. Dirks, Michael J. Ellis, Gillian Morrison, Samuel Marguerat, Sara Castro Devesa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Brooks, L J, Clements, M P, Burden, J J, Kocher, D, Richards, L, Devesa, S C, Zakka, L, Woodberry, M, Ellis, M, Jaunmuktane, Z, Brandner, S, Morrison, G, Pollard, S M, Dirks, P B, Marguerat, S & Parrinello, S 2021, ' The white matter is a pro-differentiative niche for glioblastoma ', Nature Communications, vol. 12, no. 1, pp. 2184 . https://doi.org/10.1038/s41467-021-22225-w
Nature Communications
Brooks, L J, Clements, M P, Burden, J J, Kocher, D, Richards, L, Devesa, S C, Zakka, L, Woodberry, M, Ellis, M, Jaunmuktane, Z, Brandner, S, Morrison, G, Pollard, S M, Dirks, P B, Marguerat, S & Parrinello, S 2021, ' The white matter is a pro-differentiative niche for glioblastoma ', Nature Communications, vol. 12, no. 1, pp. 2184 . https://doi.org/10.1038/s41467-021-22225-w
Nature Communications
Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma stem cells are maintained in specialised microenvironments, but whether, or how, they undergo lineage progression out
Autor:
Sara Badodi, Nicola Pomella, Yau Mun Lim, Sebastian Brandner, Gillian Morrison, Steven M Pollard, Xinyu Zhang, Nicolae Radu Zabet, Silvia Marino
Publikováno v:
Neuro-oncology. 24(8)
Background Epigenetic changes play a key role in the pathogenesis of medulloblastoma (MB), the most common malignant pediatric brain tumor. Methods We explore the therapeutic potential of BMI1 and MAPK/ERK inhibition in BMI1High;CHD7Low MB cells and
Autor:
Magda, Gerigk, Harry, Bulstrode, HaoTian Harvey, Shi, Felix, Tönisen, Camilla, Cerutti, Gillian, Morrison, David, Rowitch, Yan Yan Shery, Huang
Publikováno v:
Lab on a Chip
Glioblastoma multiforme (GBM) is the most common and the most aggressive type of primary brain malignancy. Glioblastoma stem-like cells (GSCs) can migrate in vascular niches within or away from the tumour mass, increasing tumour resistance to treatme
Autor:
Simon R. Tomlinson, Kirsty M. Ferguson, Charles A. C. Williams, Richard A. Anderson, Neza Alfazema, Leanne Bradley, Benjamin Southgate, Alex von Kriegsheim, Maria Angeles Marques-Torrejon, Faye L Robertson, Gillian Morrison, Vivien Grant, Steven M. Pollard, Carla Blin, Jimi Wills, James Ashmore, Raul Bardini Bressan
Publikováno v:
Bressan, R B, Southgate, B, Ferguson, K M, Blin, C, Grant, V, Alfazema, N, Wills, J C, Marques, M A, Morrison, G M, Ashmore, J, Robertson, F, Williams, C A C, Bradley, L, von Kriegsheim, A, Anderson, R A, Tomlinson, S R & Pollard, S M 2021, ' Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants ', Cell Stem Cell, vol. 28, no. 5, pp. 877-893.e9 . https://doi.org/10.1016/j.stem.2021.01.016
Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3.3-K2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b62ac005e0806ba597ff012910e68b7
https://www.pure.ed.ac.uk/ws/files/253710541/mmc4.pdf
https://www.pure.ed.ac.uk/ws/files/253710541/mmc4.pdf
Autor:
HaoTian H. Shi, Yan Yan Shery Huang, Camilla Cerutti, Felix Tönisen, Magda Gerigk, David H. Rowitch, Harry Bulstrode, Gillian Morrison
Publikováno v:
Lab on a Chip, 21, 2343-2358
Lab on a Chip, 21, 12, pp. 2343-2358
Lab on a Chip, 21, 12, pp. 2343-2358
Contains fulltext : 235468.pdf (Publisher’s version ) (Closed access) Glioblastoma multiforme (GBM) is the most common and the most aggressive type of primary brain malignancy. Glioblastoma stem-like cells (GSCs) can migrate in vascular niches with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274cfcad49395e7689178194f9dabea2
https://doi.org/10.1039/d1lc00271f
https://doi.org/10.1039/d1lc00271f
Autor:
Harry Bulstrode, Yan Yan Shery Huang, Rowitch David, Camilla Cerutti, Gillian Morrison, Magda Gerigk, Felix Toenisen, HaoTian H. Shi
Glioblastoma multiforme (GBM), is the most common and the most aggressive type of primary brain malignancy. Glioblastoma stem-likecells (GSCs) are able to migrate in vascular niches within or away from the tumour mass, increasing tumour resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4578e6d86f879e98410c9860d0b82e49
https://doi.org/10.1101/2020.12.23.424179
https://doi.org/10.1101/2020.12.23.424179